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| 1 | High-Efficiency Genome Editing in Arabidopsis Using YAO Promoter-Driven CRISPR/Cas9 System显示文摘 | Yan, Liuhua Wei, Shaowei Wu, Yaorong Hu, Ruolan Li, Hongju Yang, Weicai Xie, Qi | 2015 | Molecular Plant2015，8，12： | 50 |
| 2 | Simultaneous removal of COD and nitrogen using a novel carbon-membrane aerated biofilm reactor显示文摘膜给简历电影反应堆充气了是为废水处理的一种有希望的技术。在这研究,碳膜给简历电影反应堆(CMABR ) 充气了被开发了,到同时把碳 organics 和氮从一个反应堆移开。当它与 20 h 的一水力的保留时间(HRT ) 被操作,结果证明 CMABR 有一个高化学的氧要求(货到付款) 和氮移动效率,并且它也显示出完美的表演,就算 HRT 被弄短到 12 h。在这个时期,货到付款,氨氮(NH4+-N ) ,和总氮(TN ) 的移动效率分别地到达了 86% , 94% ,和 84% 。然而,当 HRT 被弄短到 8 h, NH4+-N 和 TN 的移动效率很快衰退了。这因为非编织的纤维和很高器官的装载率上的生物资源的过多的生长。荧光原位杂交(鱼) 分析显示氧化的氨细菌(AOB ) 主要在简历电影的内部层被散布。在一部简历电影的 AOB 和 eubacteria 的共存能提高货到付款和氮的同时的移动。 | HU Shaowei YANG Fenglin SUN Cui ZHANG Jianye WANG Tonghua | 2008 | Journal of Environmental Sciences2008，20，2： | 12 |
| 3 | Prescribed Performance Finite-Time Tracking Control for Uncertain Nonlinear Systems显示文摘This work investigates the finite-time tracking control problem for a class of uncertain strict-feedback nonlinear systems from a new perspective. First, a novel concept called finite-time performance function (FTPF) is defined. Further, a new sufficien t condition of finite-time st ability is derived and the tracking error can converge to a predefined region within a finite-time interval. The design process of the proposed technique is simpler. Finally, four simulation examples are carried out to illustrate the effectiveness of presented method. | JING Yuanwei LIU Yang ZHOU Shaowei | 2019 | Journal of Systems Science & Complexity2019，32，3： | 11 |
| 4 | RIP1-dependent linear and nonlinear recruitments of caspase-8 and RIP3 respectively to necrosome specify distinct cell death outcomes显示文摘There remains a significant gap in our quantitative understanding of crosstalk between apoptosis and necroptosis pathways.By employing the SWATH-MS technique,we quantified absolute amounts of up to thousands of proteins in dynamic assembling/de-assembling of TNF signaling complexes.Combining SWATH-MS-based network modeling and experimental validation,we found that when RIP1 level is below~1000 molecules/cell(mpc),the cell solely undergoes TRADD-dependent apoptosis.When RIP1 is above~1000 mpc,pro-caspase-8 and RIP3 are recruited to necrosome respectively with linear and nonlinear dependence on RIP1 amount,which well explains the co-occurrence of apoptosis and necroptosis and the paradoxical obser-vations that RIP1 is required for necroptosis but its increase down-regulates necroptosis.Higher amount of RIP1(>~46,000 mpc)suppresses apoptosis,leading to necroptosis alone.The relation between RIP1 level and occurrence of necroptosis or total cell death is biphasic.Our study provides a resource for encoding the com-plexity of TNF signaling and a quantitative picture how distinct dynamic interplay among proteins function as basis sets in signaling complexes,enabling RIP1 to play diverse roles in governing cell fate decisions. | Xiang Li Chuan-Qi Zhong Rui Wu Xiaozheng Xu Zhang-Hua Yang Shaowei Cai Xiurong Wu Xin Chen Zhiyong Yin Qingzu He Dianjie Li Fei Xu Yihua Yan Hong Qi Changchuan Xie Jianwei Shuai Jiahuai Han | 2021 | Protein & Cell2021，12，11： | 5 |
| 5 | Plasmonic resonance-linewidth shrinkage to boost biosensing显示文摘Coupling effects of surface plasmon resonance(SPR)induce changes in the wavelength,intensity,and linewidth of plasmonic modes.Here,inspired by coupling effects,we reveal an abrupt linewidth-shrinking effect in 2 D gold nanohole arrays at the azimuthal angle of 45°arising from the interference of two degenerate SPR modes.We further demonstrate the biosensing capability under various excitation conditions for detecting the critical molecular biomarker of prostatic carcinoma,and achieve the maximum sensitivity at this angle.Our study not only enhances the understanding toward plasmonic resonance-linewidth shrinking,but also provides a promising strategy to greatly improve biosensing performance by light manipulation on plasmonic nanostructures. | Min Gao Weimin Yang Zhengying Wang Shaowei Lin Jinfeng Zhu Zhilin Yang | 2020 | Photonics Research2020，8，7： | 4 |
| 6 | Syntheses and Insecticidal Activity of Spirocyclic Tetronic Acid Derivatives Containing Oxime Ether Moiety显示文摘In order to develop novel spirocyclic tetronic acid lead compounds,a series of new spirocyclic tetronic acid derivatives containing oxime ether moiety was synthesized and bioassayed.The stmctures of 16 target compounds were characterized by lH NMR spectra,13C NMR spectra and high-resolution mass spectrometer(HRMS).Preliminary bioassays indicated that most of the title compounds displayed excellent insecticidal activity against Aphis fabae and Nilapmyata lugens at 100 mg/L.In particular,compound 6k showed the similar activity(LC50=6.87 mg/L)against A.fabae as the spirotetramat(LC50=4.56 mg/L)and had better efIects(LC50=l.64 mg/L)against N.lugens in comparison with spirotetramat(LC5o=7.90 mg/L).The study showed that compound 6k exhibited more promising and broad-spectrum insecticide activity and may serve as a new insecticidal agent for sucking pests. | ZHAO Yang CHENG Jingli XIE Zhengang FANG Shaowei ZHAO Jinhao | 2020 | Chemical Research in Chinese Universities2020，36，5： | 3 |
| 7 | Prediction of a common neutralizing epitope of H5N1 avian influenza virus by in silico molecular docking显示文摘The H5N1 avian influenza virus (AIV) has widely spread in Asia, Europe and Africa, making a large amount of economic loss. Recently, our research group has screened a common neutralizing mono- clonal antibody named 8H5, which can neutralize almost all H5 subtype AIV ever isolated so far. Obvi- ously, this monoclonal antibody would benefit for research and development of the universal AIV vac- cine and design of the drug against H5N1 AIV in high mutation rate. In this study, the homology mod- eling was applied to generate the 3D structure of 8H5 Fab fragment, and 'canonical structure' method was used to define the specified loop conformation of CDR regions. The model was subjected to en- ergy minimization in cvff force field with Discovery module in Insight II program. The resulting model has correct stereochemistry as gauged from the Ramachandran plot calculation and good 3D-structure compatibility as assessed by interaction energy analysis, solvent accessible surface (SAS) analysis, and Profiles-3D approach. Furthermore, the 8H5 Fab model was subjected to docking with three H5 subtype hemagglutinin (HA) structures deposited in PDB (ID No: 1jsm, 2ibx and 2fk0) respectively. The result indicates that the three docked complexes share a common binding interface, but differ in bind- ing angle related with HA structure similarity between viral subtypes. In the light of the three HA inter- faces with structural homology analysis, the common neutralizing epitope on HA recognized by 8H5 consists of 9 incontinuous amino acid residues: Asp68, Asn72, Glu112, Lys113, Ile114, Pro118, Ser120, Tyr137, Tyr252 (numbered as for 1jsm sequence). The primary purpose of the present work is to provide some insight into structure and binding details of a common neutralizing epitope of H5N1 AIV, thereby aiding in the structure-based design of universal AIV vaccines and anti-virus therapeutic drugs. | YAN YuanQing LI ShaoWei YANG ChunYan LUO WenXin WANG MingQiao CHEN YiXin LUO HaiFeng wu Ting ZHANG Jun XIA NingShao | 2008 | Chinese Science Bulletin2008，53，6： | 2 |
| 8 | Zeolite membranes for ion separations from aqueous solution 显示文摘 | Dong Junhang Xu Zhi Yang Shaowei | 2015 | Current Opinion in Chemical Engineering2015，8，： | 1 |
| 9 | Cardiorespiratory Effects of Indoor Ozone Exposure Associated with Changes in Metabolic Profiles among Children:A Repeated-Measure Panel Study显示文摘Ozone is one of the major gaseous pollutants associated with short-term adverse cardiopulmonary effects,even at concentrations below the current indoor air quality limits.However,the underlying biological mechanisms of cardiorespiratory changes with exposure to ozone remain unclear.To further explore molecular linkages between indoor ozone exposure and relevant cardiorespiratory effects,a repeated-measure panel study including 46 schoolchildren was conducted and real-time exposure measurements including ozone were performed inside classrooms every weekday during the study period.Repeated health measurements and urine sample collection were conducted in each participant.Ultra-high-performance liquid chromatography/tandem mass spectrometry and meet-in-metabolite approach were used in metabolomics analysis.Methods including mixed-effect models were adopted to identify metabolites associated with ozone exposure or health indices.Nine metabolites were found to be associated with ozone after mixed-effect model analysis,which are mainly involved in amino acid and bile acid metabolism.Boys may have a greater decrease in bile acid and RNA related metabolites.Four of the nine ozone-related metabolites were also associated with cardiorespiratory function indices.Furthermore,26.67%of the positive association between ozone and heart rate was mediated by cholestane-3,7,12,25-tetrol-3-glucuronide.Exposure to ozone below the current indoor standards was associated with the deteriorated cardiovascular function by disturbing bile acid and endogenous nitric oxide-related oxidation and inflammation,and associated with the exacerbated airway inflammation by reducing GPx-related anti-oxidation.The results provide metabolic evidence of the cardiorespiratory effects of indoor ozone exposure.Indoor ozone pollution should be controlled further,and more attention should be paid to preventing its adverse health effects,especially in children. | Shan Liu Qingyu Huang Xi Zhang Wei Dong Wenlou Zhang Shaowei Wu Di Yang Bingru Nan Jie Zhang Heqing Shen Xinbiao Guo Furong Deng | 2021 | The Innovation2021，2，1： | 1 |
| 10 | Self-Catalyzed Rechargeable Lithium-Air Battery by in situ Metal Ion Doping of Discharge Products: A Combined Theoretical and Experimental Study显示文摘Lithium-air battery has emerged as a viable electrochemical energy technology;yet a substantial overpotential is typically observed,due to the insulating nature of the discharge product Li_(2)O_(2) that hinders the reaction kinetics and device performance.Furthermore,finite solid–solid/-liquid interfaces are formed between Li_(2)O_(2) and catalysts and limit the activity of the electrocatalysts in battery reactions,leading to inadequate electrolytic efficiency.Herein,in-situ doping of Li_(2)O_(2) by select metal ions is found to significantly enhance the lithium-air battery performance,and Co^(2+)stands out as the most effective dopant among the series.This is ascribed to the unique catalytic activity of the resulting Co-O_(x) sites towards oxygen electrocatalysis,rendering the lithium-air battery self-catalytically active.Theoretical studies based on density functional theory calculations show that structural compression occurs upon Co^(2+)doping,which lowers the energy barrier of Li_(2)O_(2) decomposition.Results from this study highlight the significance of in situ electrochemical doping of the discharge product in enhancing the performance of lithium-air battery. | Mengwei Yuan Zemin Sun Han Yang Di Wang Qiming Liu Caiyun Nan Huifeng Li Genban Sun Shaowei Chen | 2023 | Energy & Environmental Materials2023，6，1： | 1 |
| 11 | The development of a novel hybrid aerating membrane-anaerobic baffed reactor for the simultaneous nitrogen and organic carbon removal from wastewater显示文摘 | Shaowei Hu Fenglin Yang Sitong Liu | 2009 | Water Research2009，43，： | 1 |
| 12 | Numerical Investigation on Press Forming of Self - Lu- bricating Spherical Plain Bearings 显示文摘 | Wang Xiumei Lti Shaowei Yang Richard ( Chunhui ) | 2013 | International Journal of Materials and Product Technology2013，47，： | 1 |
| 13 | Treatment of STAT5b-RARA positive acute promyelocytic leukemia by Venetoclax combining with homoharringtonine, cytarabine: A case report and literature review显示文摘Introduction:Acute promyelocytic leukemia(APL)is mostly due to the chromosome translocation t(15;17)(q22;q12),leading to the formation of PML-RARA fusion protein.Some patients carried rare translocation involving RARA gene,who were called variant APL caused by RAR family(RARA,RARB,and RARG)and partner genes.STAT5b-RARA was a rare type of molecular genetic abnormality with unfavorable prognosis which have been reported in only 18 cases in variant APL.Knowledge of STAT5b-RARA(+)APL treatment is still limited.Case report:We presented a 38-year-old female variant APL case,who was STAT5b-RARA positive detected by reverse transcription polymerase chain reaction.The patient failed to respond after four-drug combined induction chemotherapy:idarubicin,cytarabine,all trans retinoic acid,and arsenic trioxide(As 2 O 3).Then,the patient was re-induced with azacytidine,but still failed to achieve complete remission(CR).Next,she was treated with Venetoclax combining with homoharringtonine and cytarabine as the salvage therapy and achieved CR.Later,the patient received hematopoietic stem cell transplantation after 4 cycles of consolidation therapy.Conclusion:Venetoclax combining with homoharringtonine and cytarabine has been used as the salvage therapy in the STAT5b-RARA positive APL successfully. | Guangji Zhang Yang Song Li Wan Kaiqi Liu Shaowei Qiu Jianxiang Wang Yingchang Mi | 2022 | Blood Science2022，4，2： | 1 |
| 14 | Acoustic Prediction and Risk Evaluation of Shallow Gas in Deep-Water Areas显示文摘Shallow gas is a potential risk in deep-water drilling that must not be ignored,as it may cause major safety problems,such as well kicks and blowouts.Thus,the pre-drilling prediction of shallow gas is important.For this reason,this paper conducted deep-water shallow gas acoustic simulation experiments based on the characteristics of deep-water shallow soil properties and the theory of sound wave speed propagation.The results indicate that the propagation speed of sound waves in shallow gas increases with an in-crease in pressure and decreases with increasing porosity.Pressure and sound wave speed are basically functions of the power expo-nent.Combined with the theory of sound wave propagation in a saturated medium,this paper establishes a multivariate functional relationship between sound wave speed and formation pressure and porosity.The numerical simulation method is adopted to simulate shal-low gas eruptions under different pressure conditions.Shallow gas pressure coefficients that fall within the ranges of 1.0-1.1,1.1-1.2,and exceeding 1.2 are defined as low-,medium-,and high-risk,respectively,based on actual operations.This risk assessment me-thod has been successfully applied to more than 20 deep-water wells in the South China Sea,with a prediction accuracy of over 90%. | YANG Jin WU Shiguo TONG Gang WANG Huanhuan GUO Yongbin ZHANG Weiguo ZHAO Shaowei SONG Yu YIN Qishuai XU Fei | 2022 | Journal of Ocean University of China2022，21，5： | 1 |
| 15 | Two-dimensional porous zinc cobalt sulfide nanosheet arrays with superior electrochemical performance for supercapatteries显示文摘Unique two-dimensional(2D)porous nanosheets with overwhelmingly rich channels and large specific surface area exhibit superior electrochemical capacitance performance,as compared to the conventional zero-and one-dimensional counterparts.As ternary transition metal sulfides(TMSs)are well recognized for their high electrochemical activity and capacity,and the replacement of oxygen with sulfur may result in high stability and flexible properties of the nanomaterials,as compared to transition metal oxides,herein we report the synthesis of 2D porous nanosheet arrays of Zn_(x)Co_(1-x)S(x=0,0.25,0.5,0.75,and 1)via a facile hydrothermal process.Due to the synergistic effect of the metal components and a unique 2D porous structure,the Zn_(0.5)Co_(0.5)S electrode was found to stand out as the best among the series,with a high specific capacity of 614 C g^(-1)at 1 A g^(-1)and excellent cycle retention rate of 90%over 10,000 cycles at 10 A g^(-1).Notably,a supercapattery based on a Zn_(0.5)Co_(0.5)S positive electrode and an activated carbon(AC)negative electrode(Zn_(0.5)Co_(0.5)S//AC)was found to display a 1.6 V voltage window,a 61 mA h g^(-1)specific capacity at 1 A g^(-1),a 49 Wh kg^(-1)energy density at 957 W kg^(-1)power density,and excellent cycling performance(88%over 10,000 cycles),suggesting tremendous potential of Zn_(0.5)Co_(0.5)S in the development of high-performance supercapattery devices. | Yang Li Ziyang Luo Shunfei Liang Huizhen Qin Xun Zhao Lingyun Chen Huayu Wang Shaowei Chen | 2021 | Journal of Materials Science & Technology2021，，30： | 1 |
| 16 | Blockade of deubiquitinase YOD1 degrades oncogenic PML/RARα and eradicates acute promyelocytic leukemia cells显示文摘In most acute promyelocytic leukemia(APL)cells,promyelocytic leukemia(PML)fuses to retinoic acid receptor α (RARα)due to chromosomal translocation,thus generating PML/RARαoncoprotein,which is a relatively stable oncoprotein for degradation in APL.Elucidating the mechanism regulating the stability of PML/RARαmay help to degrade PML/RARαand eradicate APL cells.Here,we describe a deubiquitinase(DUB)-involved regulatory mechanism for the maintenance of PML/RARαstability and develop a novel pharmacological approach to degrading PML/RARαby inhibiting DUB.We utilized a DUB siRNA library to identify the ovarian tumor protease(OTU)family member deubiquitinase YOD1 as a critical DUB of PML/RARα.Suppression of YOD1 promoted the degradation of PML/RARα,thus inhibiting APL cells and prolonging the survival time of APL cell-bearing mice.Subsequent phenotypic screening of small molecules allowed us to identify ubiquitin isopeptidase inhibitor I(G5)as the first YOD1 pharmacological inhibitor.As expected,G5 notably degraded PML/RARαprotein and eradicated APL,particularly drug-resistant APL cells.Importantly,G5 also showed a strong killing effect on primary patient-derived APL blasts.Overall,our study not only reveals the DUB-involved regulatory mechanism on PML/RARαstability and validates YOD1 as a potential therapeutic target for APL,but also identifies G5 as a YOD1 inhibitor and a promising candidate for APL,particularly drug-resistant APL treatment. | Xuejing Shao Yingqian Chen Wei Wang Wenxin Du Xingya Zhang Minyi Cai Shaowei Bing Ji Cao Xiaojun Xu Bo Yang Qiaojun He Meidan Ying | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 1 |
| 17 | Identifying the roles of Ce^(3+)-OH and Ce-H in the reverse water-gas shift reaction over highly active Ni-doped CeO_(2) catalyst显示文摘Nickel-CeO_(2)-based materials are commonly used for the thermal catalytic hydrogenation of CO_(2).However,high Ni loadings and low CO selectivity restrict their use in the reverse water–gas shift(RWGS)reaction.Herein,we demonstrate a highly active,robust,and low-Ni-doped(1.1 wt.%)CeO_(2) catalyst(1.0-Ni-CeO_(2)).The Ni-based-mass-specific CO formation rate reaches up to 1,542 mmol·gNi^(−1)·h^(−1) with 100%CO selectivity at 300°C for 100 h,among the best values reported in the literature.Density functional theory(DFT)and diffuse reflectance infrared Fourier transform spectroscopy(DRIFTS)results reveal that the enhanced catalytic activity is attributed to the abundant Ce–H species,while the high selectivity results from low CO affinity.More importantly,a new reaction mechanism is proposed,which involves the reduction of bicarbonate to generate formate intermediate and CO by the H−released from Ce–H species.The new findings in this work will benefit the design of economic,efficient,and robust catalysts for low-temperature RWGS reactions. | Haidong Shen Yujuan Dong Shaowei Yang Yuan He Qimeng Wang Yueling Cao Wenbin Wang Tianshuai Wang Qiuyu Zhang Hepeng Zhang | 2022 | Nano Research2022，15，7： | 1 |
| 18 | The development of a novel hybrid aerating membrane-anaerobic baffled reactor for the simultaneous nitrogen and organic carbon removal from wastewater显示文摘 | HU Shaowei YANG Fenglin LIU Sitong | 2009 | Water Res2009，43，2： | 1 |
| 19 | Zeolite membranes for ion separations from aqueous solution 显示文摘 | Dong Junhang Xu Zhi Yang Shaowei | 2015 | Current Opinion in Chemical Engineering2015，，8： | 1 |
| 20 | The mechanism of slope instability due to rainfall-induced structural decay of earthquake-damaged loess显示文摘Natural loess slopes are characterized by a strong geological structure,which is an important factor in maintaining slope stability.The magnitude and duration of the earthquake may disturb the soil structure at different levels degrees,locally changing the arrangement between soil particles.The process of rainfall humidification weakens the cementation between soil particles,and the disturbance and humidification change the structural state of the soil,which in turn causes sliding of the slope along with the decay of soil mechanical properties.As slope instability is often the result of a series of post-earthquake ripple effects,it is of great scientific significance to study the mechanism of slope instability due to the structural decay of earthquake-damaged loess exacerbated by rainfall.In this paper,the impact of structural decay of loess on slope stability is simulated by GEOSTUDIO software under three conditions:pre-earthquake rainfall,post-earthquake rainfall and earthquake,taking the landslide in Buzi Village,Min County,Gansu Province as an example.The comparative analysis of the calculation results shows that the structural properties of the slope without earthquake disturbance are influenced by infil-tration amount.When it is fully saturated,the structural properties are similar to those of saturated soil,and the safety factor is reduced by 12.9%.In addition,the earthquake intensity and duration have different degrees of structural damage to the soil.When the structure is fully damaged,it is similar to that of remodelled soil,and the safety factor is reduced by 45.84%.Notably,the process of the earthquake and the following humidification generates the most serious damage to the loess structure,with a reduction in the safety factor of up to 56.15%.The quantitative analysis above obviously illustrates that the post-earthquake rainfall causes the most severe damage to structural loess slopes,and the resulting landslide hazard should not be underestimated. | Hu Tao Mengmeng Zhang Li Gong Xi Shi Yijie Wang Guoqiang Yang Shaowei Lei | 2022 | Earthquake Research Advances2022，2，3： | 1 |
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