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| 1 | Tumor suppressor miR-128-3p inhibits metastasis and epithelial-mesenchymal transition by targeting ZEB1 in esophageal squamous-cell cancer显示文摘MicroRNAs (miRNAs ) 是在 post-transcriptional 层次调整多重生物功能的一些短 RNA,例如 tumorigenic 过程,煽动性的损害和房间 apoptosis。(ZEB1 ) 锌手指电子盒子有约束力的 homeobox 因素 1 是上皮间充质的转变(EMT ) 的一个关键调停人。它包括人的食道的有鳞房间的癌(ESCC ) 导致各种各样的癌症的恶意的前进。在这研究,我们发现 miR-128-3p 由使用 PCR 是在 ESCC 纸巾和房间的 downregulated。而且, miR-128-3p 的下面调整的表示被证明与 ESCC 病人的差的预后被联系并且可能被认为是一个独立预示的因素。然后,我们在 ESCC 房间检验了 miR-128-3p 的角色,并且发现 miR-128-3p 能在 vitro 压制房间迁居和侵略。而且, ZEB1 被证实是由酶记者试金的 miR-128-3p 的一个直接目标。营救实验证明 EMT 被 miR-128-3p 经由 ZEB1 的抑制调整。一起拿所有,我们断定 miR-128-3p 压制 EMT,经由 ZEB1 的转移,和 miR-128-3p 可以是在 ESCC 的一个批评调停人。 | Lili Zhao Rui Li Shanling Xu Yi Li Pei Zhao Wei Dong Zhenjun Liu Qian Zhao Bo Tan | 2018 | Acta Biochimica et Biophysica Sinica2018，50，2： | 21 |
| 2 | Integrative single-cell analysis of transcriptome,DNA methylome and chromatin accessibility in mouse oocytes显示文摘Oocyte growth is a key step in forming mature eggs that are ready to be fertilized.The states and modifications of chromatin represent critical sources of information for this process.However,the dynamics and interrelations of these chromatin characteristics remain elusive.In this study,we developed an improved scCOOL-seq technique (iscCOOL-seq),which is a multiomics,single-cell and single-base resolution method with high mapping rates,and explored the chromatin accessibility landscape and its relationship to DNA methylation in growing mouse oocytes.The most dramatic change in chromatin accessibility occurs during oocyte growth initiation,accompanied with prominent transcriptome alterations and an elevated variation in DNA methylation levels among individual oocytes.Unlike CpG islands (CGIs),partially methylated domains (PMDs)are associated with a low density of nucleosome-depleted regions (NDRs)during the whole maturation period.Surprisingly,highly expressed genes are usually associated with NDRs at their transcriptional end sites (TESs).In addition,genes with de novo methylated gene bodies during oocyte maturation are already open at their promoters before oocyte growth initiation.Furthermore,epigenetic and transcription factors that might be involved in oocyte maturation are identified.Our work paves the way for dissecting the complex, yet highly coordinated,epigenetic alterations during mouse oocyte growth and the establishment of totipotency. | Chan Gu Shanling Liu Qihong Wu Lin Zhang Fan Guo | 2019 | Cell Research2019，29，2： | 14 |
| 3 | A new-generation sand and dust storm forecasting system GRAPES_CUACE/Dust:Model development,verification and numerical simulation显示文摘Based on the new-generation Global/Regional Assimilation and PrEdiction System(GRAPES) developed by the Numerical Prediction Research Center,China Meteorological Administration and the Chinese Unified Atmospheric Chemistry Environment for Dust Atmospheric Chemistry Module(CUACE/Dust) developed by the Centre for Atmosphere Watch and Services(CAWAS) of the Chinese Academy of Meteorological Sciences(CAMS) ,the China sand and dust storm forecasting system GRAPES /CUACE-Dust model has been established.The latest data of land desertification,optical properties of China sand and dust aerosols,daily soil moisture and snow cover over China main land was introduced in this system.The system showed good performance in mass conservation.The comparisons of real-time prediction outputs with surface observations and aerosol indices derived from TOMS ozone spectrophotometers(TOMS AI) indicate that the model can predict the outbreak,development,transport and depletion processes of sand and dust storms accurately over China and the East Asian region.The system makes real-time quantitative prediction of a series of elements including sand and dust injection from the surface,dry and wet deposition amount,dust concentration and optical depth.We selected 7 major dust storms occurring in April 2006 and analyzed the spatiotemporal distribution patterns of dust emission,dry and wet deposition and atmospheric load in this paper.The results showed that about 225 million tons of dust were emitted into the atmosphere from the deserts over east Asia in that month.The 3 major sand and dust sources were just as the following:The deserts in northern Inner Mongolia and the boundary area around China-Mongolia were the first dust sources with a contribution of 153 million tons accounting for 68%of the total emission.The Taklimakan Desert ranked second and contributed approximately 40 million tons accounting for 17%of the dust emission.The Onqin Daga Sandland emitted about 15 million tons or 7%of the total emission.The contributions from other deserts,sandy lands and abandoned farmlands were about only 8%of the total dust emission.The total deposition over the East Asian region in April 2006 was 136 million tons.The regional distribution of dust deposition showed that the 3 major sources were also the major deposition areas.The deposition amount in the 3 major sources accounted for 78%of the total with about 135 million tons falling back to the source regions.The secondary deposition area was the China mainland downriver,where more than 2 million tons deposited accounting for 16%of the total deposition.The deposition over the region east of 120°E including China off-shore regions,Korean Peninsula,Japan and the West Pacific took only 6%of the total deposition,which was about 850000 tons.The analysis on dry and wet deposition showed that dry deposition dominated in the process,accounting for 94%of the total sand and dust depositions in the period and wet deposition only was around for 6%,since it was generally dry with less rainfall over northern China in April. | WANG Hong GONG ShanLing ZHANG HongLiang CHEN Yong SHEN XueShun CHEN DeHui XUE JiShan SHEN YuanFang WU XiangJun JIN ZhiYan | 2010 | Chinese Science Bulletin2010，55，7： | 10 |
| 4 | Robust adaptive H_(∞) control for networked uncertain semi-Markov jump nonlinear systems with input quantization显示文摘Dear editor,Markov jump systems(MJSs),as one kind of switched systems,are a good candidate for modeling physical systems subject to abrupt variation in their structures or parameters caused by many reasons such as subsystem interconnection change and environmental disturbance[1,2]. | Shanling DONG Guanrong CHEN Meiqin LIU Zheng-Guang WU | 2022 | Science China(Information Sciences)2022，65，8： | 2 |
| 5 | A Supper Efficiency Model for Ranking Efficient Units in Data Envelopment Analysis显示文摘 | Li Shanling Jahanshahloo G R Khodabakhshi M | 2007 | Applied Mathematics and Computation2007，184，2： | 1 |
| 6 | Low temperature conditioning reduces postharvest chilling injury in Ioquat fruit 显示文摘 | Cai C Xu C J ShanL L etal | 2006 | Postharvest Biology and Technology2006，41，： | 1 |
| 7 | Death-associated protein kinaserelated protein 1, a novel serine/threonine kinase involved in apoptosis显示文摘 | Inbal B Shanl G Cohen O | 2000 | Mol Cell Biol2000，20，3： | 1 |
| 8 | Using data envelopment analysis to evaluate efficiency in the economic performance of Chinese cities显示文摘 | Abraham Charnes William W Cooper Shanling Li | 1989 | Socio-Economic Planning Sciences1989，23，6： | 1 |
| 9 | Comparisons and evaluations of alternative approaches to the treatment of congestion in DEA显示文摘 | W.W. Cooper Bisheng Gu Shanling Li | 2001 | European Journal of Operational Research2001，，1： | 1 |
| 10 | Transvaginalsurgicaltreatmentofce-sareanscarectopicpregnancy显示文摘 | LeA ShanL XiaoT etal | 2013 | ArchGynecolObstet2013，287，： | 1 |
| 11 | Reaction of differenct cropsto alternate dry wetting environment显示文摘 | ShanL Sup GuoLK | 2000 | Acta Bdt Bor Sin2000，20，2： | 1 |
| 12 | Structural Properties of Buyback Contracts for Price-Setting Newsvendors显示文摘 | Yuyue Song Saibal Ray Shanling Li | 2008 | Manufacturing & Service Operations Management2008，，1： | 1 |
| 13 | Selectively targeting estrogen receptors for cancer treatment 显示文摘 | Shanle EK Xu W | 2010 | Adv Drug Deliv Rev2010，62，13： | 1 |
| 14 | GranulatingprocessofmorindeamfficinalisoligosaccharidescapsulebasedontopspraytechniquebyfluidizedbedcoaterfJ]显示文摘 | SHANL WANGYL YANGMY etal | | 国际学研究杂志0，，： | 1 |
| 15 | Sensitivity and Stability Analysis in DEA: Some Recent Development 显示文摘 | W W Cooper Shanling Li L M Seiford | 2001 | Journal of Productivity Analysis2001，，15： | 1 |
| 16 | Using DEA To evaluate 29 Canadian textile companies — Considering returns to scale显示文摘 | Pankaj Chandra William W. Cooper Shanling Li Atiqur Rahman | 1998 | International Journal of Production Economics1998，，2： | 1 |
| 17 | Determination of Rare Earth Elements in Navel Oranges from Different Geographical Regions of China by Inductively Coupled Plasma-Mass Spectrometry显示文摘 | Shanling Hu Jun Xue Yan Lin Jian-Ping Yu Jianguang Zhou | 2014 | Analytical Letters2014，，8： | 1 |
| 18 | A super-efficiency model for ranking efficient units in data envelopment analysis显示文摘 | Shanling L Jahanshahloo G R Khodabakhshi M | 2007 | Applied Mathematics and Computation2007，184，2： | 1 |
| 19 | Lowtemperaturecondi-tioningreducespostharvestchillinginjuryinloquatfruit显示文摘 | CAIC XUC SHANL etal | 2006 | PostharvestBiolTec2006，41，3： | 1 |
| 20 | Endocrine disrupting chemicals targeting estrogen receptor signaling:identification and mechanisms of action显示文摘 | Shanle EK Xu W | 2011 | Chem Res Toxicol2011，24，： | 1 |
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