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| 1 | AGC1.5 Kinase Phosphorylates RopGEFs to Control Pollen Tube Growth显示文摘在被子植物的两倍授精通过花粉试管要求无法移动的精子的指向的交货到卵。成长尖端的花粉试管的极性与顶端的血浆膜通过植物(ROP-GTP ) 的活跃 Rho GTPases 的动态协会被维持。为 ROP (RopGEFs ) 的 Guanine 核苷酸交换因素催化 ROP 的激活并且从而影响空间与时间的 ROP 发信号。而 RopGEFs 被发现了是 phosphorylated 蛋白质,为他们的 phosphorylation 在负责的 kinases ? vivo 和在花粉试管生长的 RopGEF phosphorylation 的生物后果仍然保持不清楚。我们这里报导细胞质的 kinases 的 Arabidopsis AGC1.5 亚科在花粉试管生长期间为 ROP-GTP 的限制本地化是批评的。AGC1.5 和 AGC1.7 功能的损失在花粉试管发信号的 ROP 下游地导致了活跃 ROP 和有缺点的事件的错误目标。AGC1.5 在容易的领域的保存重量的单位残余经由他们的催化容易的领域和 phosphorylates RopGEFs 与 RopGEFs 交往。AGC1.5 和 AGC1.7 功能的损失在花粉试管导致了 RopGEFs 的错误目标,类似于由 AGC1.5 显示 RopGEFs non-phosphorylatable 的变化引起的显型。一起,我们的结果在花粉试管的极的生长期间提供机械学的卓见进 ROP 的空间与时间的激活。 | En Li Yong Cui Fu-Rong Ge Sen Chai Wei-Tong Zhang Qiang-Nan Feng Liwen Jiang Sha Li Yan Zhang | 2018 | Molecular Plant2018，11，9： | 5 |
| 2 | S-acylation of CBL10/SCaBP8 by PAT10 is crucial for its tonoplast association and function in salt tolerance显示文摘Protein S-acylation is a reversible posttranslational modification that involves the addition of a 16-carbon saturated lipid group,usually a palmitate group,to cysteine residues of a substrate protein(Hemsley and Grierson 2008;Hemsley et al.2013;Running 2014). | Sen Chai Fu-Rong Ge Yan Zhang Sha Li | 2020 | Journal of Integrative Plant Biology2020，62，6： | 4 |
| 3 | The journey to glory: receptor-like kinases in pollen tube growth显示文摘Double fertilization in angiosperm is a prerequisite for seed and fruit development and has been under close scrutiny in the past decades. Communications between male and female gametophytes are especially important in achieving successful reproduction, in which receptor-like kinases are dominant players. Here, we review progress on the functionality of receptor-like kinases(RLKs) in pollen tube growth and point out challenges facing the study of RLKs in pollen biology. | Sen Chai Furong Ge Sha Li Yan Zhang | 2016 | Science Bulletin2016，61，11： | 4 |
| 4 | A new parameterization scheme for sea surface aerodynamic roughness显示文摘更少的粗糙长度从维的分析导出的尺寸有一种关系少些挥动年龄,和尺寸粗糙的形式长度能与重要波浪高度与关系被表示。基于六个实验(HEXMAX, RASEX,简历稳定的站台,安大略湖数据分析取, CBLAST 低风) ,我们证实 Charnock 参数, zch,和尺寸更少粗糙长度, z0/Hs,依赖于波浪年龄, u */cp。而且,我们为粗糙长度构造了一个新计划,并且探索了它的敏感到磨擦速度和波浪年龄。把最新发达的 parameterization 计划(PS07 ) 与 COARE (联合海洋空气反应实验 V.3.0 ) 相结合算法,我们在 1985 年 12 月从北方海平台实验计算了数据,并且尝试了与 COARE 的另外的三个计划相比验证 PS07 的适用性。我们发现计算结果基于 PS07 接近大小。我们也进行了 PS07 与在发生在 Zhanjiang 海港的 3 台风的数据集联合的波浪的嵌套的模型在被相结合的一个实验。在在 Naozhou 岛附近的计算、观察的波浪之间的比较结果显示新 parameterization 计划(PS07 ) 有好适用性。 | Yuping Pan Wenyu Sha Shouxian Zhu Sufang Ge | 2008 | Progress in Natural Science:Materials International2008，18，11： | 2 |
| 5 | Potential therapeutic effects and applications of Eucommiae Folium in secondary hypertension显示文摘Eucommiae Folium(EF),a traditional Chinese medicine,has been used to treat secondary hypertension,including renal hypertension and salt-sensitive hypertension,as well as hypertension caused by thoracic aortic endothelial dysfunction,a high-fat diet,and oxidized low-density lipoprotein.The antihypertensive components of EF are divided into four categories:flavonoids,iridoids,lignans,and phenylpropanoids,such as chlorogenic acid,geniposide acid and pinoresinol diglucoside.EF regulates the occurrence and development of hypertension by regulating biological processes,such as inhibiting inflammation,regulating the nitric oxide synthase pathway,reducing oxidative stress levels,regulating endothelial vasoactive factors,and lowering blood pressure.However,its molecular antihypertensive mechanisms are still unclear and require further investigation.In this review,by consulting the relevant literature on the antihypertensive effects of EF and using network pharmacology,we summarized the active ingredients and pharmacological mechanisms of EF in the treatment of hypertension to clarify how EF is associated with secondary hypertension,the related components,and underlying mechanisms.The results of the network pharmacology analysis indicated that EF treats hypertension through a multicomponent,multi-target and multi-pathway mechanism.In particular,we discussed the role of EF targets in the treatment of hypertension,including epithelial sodium channel,heat shock protein70,rhoassociated protein kinase 1,catalase,and superoxide dismutase.The relevant signal transduction pathways,the ras homolog family member A(RhoA)/Rho-associated protein kinase(ROCK)and nicotinamide adenine dinucleotide phosphate(NADPH)oxidase/eNOS/NO/Ca^(2+)pathways,are also discussed. | Mengyuan Li Yanchao Zheng Sha Deng Tian Yu Yucong Ma Jiaming Ge Jiarong Li Xiankuan Li Lin Ma | 2022 | Journal of Pharmaceutical Analysis2022，12，5： | 2 |
| 6 | Targeting and signaling of Rho of plants guanosine triphosphatases require synergistic interaction between guanine nucleotide inhibitor and vesicular trafficking显示文摘Most eukaryotic cells are polarized.Common toolbox regulating cell polarization includes Rho gua-nosine triphosphatases(GTPases),in which spatio-temporal activation is regulated by a plethora of reg-ulators.Rho of plants(ROPs)are the only Rho GTPases in plants.Although vesicular trafficking was hinted in the regulation of ROPs,it was unclear where vesicle-carried ROP starts,whether it is dynamically regulated,and which components participate in vesicle-mediated ROP targeting.In addition,although vesicle trafficking and guanine nucleotide inhibitor(GDI)pathways in Rho signaling have been extensively studied in yeast,it is unknown whether the two pathways interplay.Unclear are also cellular and developmental con-sequences of their interaction in multicellular organisms.Here,we show that the dynamic targeting of ROP through vesicles requires coat protein complexⅡand ADP-ribosylation factor 1-mediated post-Golgi trafficking.Trafficking of vesicle-carried ROPs between the plasma membrane and the trans-Golgi network is mediated through adaptor protein 1 and sterol-mediated endocytosis.Finally,we show that GDI and vesicle trafficking synergistically regulate cell polar-ization and ROP targeting,suggesting that the estab-lishment and maintenance of cell polarity is regulated by an evolutionarily conserved mechanism. | Fu-Rong Ge Sen Chai Sha Li Yan Zhang | 2020 | Journal of Integrative Plant Biology2020，62，10： | 2 |
| 7 | Progress on diagnostic and prognostic markers of pancreatic cancer显示文摘Pancreatic cancer is a malignant disease characterized by low survival and high recurrence rate,whose patients are mostly at the stage of locally advanced or metastatic disease when first diagnosed.Early diagnosis is particularly important because prognostic/predictive markers help guide optimal individualized treatment regimens.So far,CA19-9 is the only biomarker for pancreatic cancer approved by the FDA,but its effectiveness is limited by low sensitivity and specificity.With recent advances in genomics,proteomics,metabolomics,and other analytical and sequencing technologies,the rapid acquisition and screening of biomarkers is now possible.Liquid biopsy also occupies a significant place due to its unique advantages.In this review,we systematically describe and evaluate the available biomarkers that have the greatest potential as vital tools in diagnosing and treating pancreatic cancer. | HONG YANG WAN LI LIWEN REN YIHUI YANG YIZHI ZHANG BINBIN GE SHA LI XIANGJIN ZHENG JINYI LIU SEN ZHANG GUANHUA DU BO TANG HONGQUAN WANG JINHUA WANG | 2023 | Oncology Research2023，31，2： | 1 |
| 8 | ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH/PSAT1/serine metabolic pathway显示文摘Colorectal cancer(CRC)is the third most common cancer in men and the second most common cancer in women worldwide.CRC is the second leading cause of cancer-related deaths.Although some progress in the treatment of CRC has been achieved,the molecular mechanism of CRC is still unclear.In this study,alcohol dehydrogenase 1C(ADH1C)was first identified as a target gene closely associated with the development of CRC by the comprehensive application of transcriptomics,proteomics,metabonomics and in silico analysis.The ADH1C mRNA and protein expression in CRC cell lines and tumor tissues was lower than that in normal intestinal epithelial cell lines and healthy tissues.Overexpression of ADH1C inhibited the growth,migration,invasion and colony formation of CRC cell lines and prevented the growth of xenograft tumors in nude mice.The inhibitory effects of ADH1C on CRC cells in vitro were exerted by reducing the expression of PHGDH/PSAT1 and the serine level.This inhibition could be partially reversed by adding serine to the culture medium.These results showed that ADH1C is a potential drug target in CRC. | Sha Li Hong Yang Wan Li Jin-yi Liu Li-wen Ren Yi-hui Yang Bin-bin Ge Yi-zhi Zhang Wei-qi Fu Xiang-jin Zheng Guan-hua Du Jin-Hua Wang | 2022 | Acta Pharmacologica Sinica2022，43，10： | 1 |
| 9 | A joint call for actions to advance taxonomy in China显示文摘Taxonomy plays an important role in understanding the origin, evolution, and ecological functionality of biodiversity. There are large number of unknown species yet to be described by taxonomists, which together with their ecosystem services cannot be effectively protected prior to description. Despite this, taxonomy has been increasingly underrated insufficient funds and permanent positions to retain young talents. Further, the impact factordriven evaluation systems in China exacerbate this downward trend, so alternative evaluation metrics are urgently necessary. When the current generation of outstanding taxonomists retires,there will be too few remaining taxonomists left to train the next generation. In light of these challenges, all co-authors worked together on this paper to analyze the current situation of taxonomy and put out a joint call for immediate actions to advance taxonomy in China. | Chaodong Zhu Arong Luo Ming Bai Michael COrr Zhonge Hou Siqin Ge Jun Chen Yibo Hu Xuming Zhou Gexia Qiao Hongzhi Kong Limin Lu Xiaohua Jin Lei Cai Xinli Wei Ruilin Zhao Wei Miao Qingfeng Wang Zhongli Sha Qiang Lin Meng Qu Jianping Jiang Jiatang Li Jing Che Xuelong Jiang Xiaoyong Chen Lianming Gao Zongxin Ren Chunlei Xiang Shixiao Luo Donghui Wu Dong Liu Yanqiong Peng Tao Su Chenyang Cai Tianqi Zhu Wanzhi Cai Xingyue Liu Hu Li Huaijun Xue Zhen Ye Xuexin Chen Pu Tang Shujun Wei Hong Pang Qiang Xie Feng Zhang Feng Zhang Xianjin Peng Aibing Zhang Taiping Gao Changfa Zhou Chen Shao Libin Ma Zhaoming Wei Yunxia Luan Ziwei Yin Wu Dai Cong Wei Xiaolei Huang Jingxian Liu Xiangsheng Chen Tianci Yi Zhisheng Zhang Zhulidezi Aishan Qin Li Hongying Hu | 2022 | Zoological Systematics2022，47，3： | 1 |
| 10 | Current Situation and Development of Technology Extension System for Suburban Agriculture:A Case Study of Hanjiang District of Yangzhou City显示文摘Through the survey on agricultural technology extension system in Hanjiang District of Yangzhou City,this paper analyzed possible problems in the agricultural technology extension system.Combining with newly revised Agricultural Technology Extension Law and modern agricultural extension theory,it discussed the new development direction.Finally,it came up with approaches and measures for establishing the agricultural technology extension system in Hanjiang District. | Jing GUO Zhengqin SHA Luying JI Sheng GE Wuguang YANG | 2015 | Asian Agricultural Research2015，7，3： | 1 |
| 11 | New insights into enhanced electrocatalytic performance of carbon supported Pd-Cu catalyst for formic acid oxidation显示文摘 | LU L SHEN L SHA Y CHEN T JIANG G GE C TANG Y CHEN Y LU T | 2012 | Electrochim Acta2012，85，： | 1 |
| 12 | Rhesus monkeys exhibiting spontaneous ritualistic behaviors resembling obsessive-compulsive disorder显示文摘Obsessive-compulsive disorder(OCD)is a chronic and debilitating psychiatric disorder that affects∼2%–3%of the population globally.Studying spontaneous OCD-like behaviors in non-human primates may improve our understanding of the disorder.In large rhesus monkey colonies,we found 10 monkeys spontaneously exhibiting persistent sequential motor behaviors(SMBs)in individual-specific sequences that were repetitive,time-consuming and stable over prolonged periods.Genetic analysis revealed severely damaging mutations in genes associated with OCD risk in humans.Brain imaging showed that monkeys with SMBs had larger gray matter(GM)volumes in the left caudate nucleus and lower fractional anisotropy of the corpus callosum.The GM volume of the left caudate nucleus correlated positively with the daily duration of SMBs.Notably,exposure to a stressor(human presence)significantly increased SMBs.In addition,fluoxetine,a serotonergic medication commonly used for OCD,decreased SMBs in these monkeys.These findings provide a novel foundation for developing better understanding and treatment of OCD. | Rongwei Zhai Geya Tong Zheqin Li Weichen Song Yang Hu Sha Xu Qiqi Wei Xiaocheng Zhang Yi Li Bingbing Liao Chenyu Yuan Yinqing Fan Ge Song Yinyin Ouyang Wenxuan Zhang Yaqiu Tang Minghui Jin Yuxian Zhang He Li Zhi Yang Guan Ning Lin Dan JStein Zhi-Qi Xiong Zhen Wang | 2023 | National Science Review2023，10，11： | 1 |
| 13 | Ultrahigh accelerating gradient and quality factor of CEPC 650 MHz superconducting radio-frequency cavity显示文摘Two 650 MHz single-cell superconducting radio-frequency(SRF)cavities used for the Circular Electron Positron Collider(CEPC)were studied to achieve a high accelerating gradient(E_(acc))and high intrinsic quality factor(Q_(0)).The 650 MHz single-cell cavities were subjected to a combination of buffered chemical polishing(BCP)and electropolishing(EP),and their E_(acc) exceeded40 MV/m.Such a high E_(acc) may result from the cold EP with more uniform removal.BCP is easy,cheap,and rough,whereas EP is complicated,expensive,and precise Therefore,the combination of BCP and EP investigated in this study is suitable for surface treatments of mass SRF cavities.Medium temperature(mid-T)furnace baking was also conducted,which demonstrated an ultrahigh Q_(0) of 8×10^(10) at 22 MV/m for both cavities,and an extremely low BCS resistance(R_(BCS))of~1.0 nΩwas achieved a2.0 K. | Peng Sha Wei-Min Pan Song Jin Ji-Yuan Zhai Zheng-Hui Mi Bai-Qi Liu Chao Dong Fei-Si He Rui Ge Liang-Rui Sun Shi-Ao Zheng Ling-Xi Ye | 2022 | Nuclear Science and Techniques2022，33，10： | 1 |
| 14 | Phosphatase of Regenerating Liver-3 Promotes Motility and Metastasis of Mouse Melanoma Cells显示文摘 | Xiaopeng Wu Hu Zeng Xianming Zhang Ying Zhao Haibo Sha Xiaomei Ge Minyue Zhang Xiang Gao Qiang Xu | 2004 | The American Journal of Pathology2004，，6： | 1 |
| 15 | Spennatogenesis following syngeneic testicular transplantation in Balb/c mice显示文摘 | MA Peng-peng GE Ye -hna WANG Sha -li | 2004 | Reproduction2004，128，2： | 1 |
| 16 | The Clinical Significance of the Variation of Plasma Endothelin in Angocardiopathy显示文摘ObJective:To study the clinical significance ofthe plasma endothelin(ET)variation in thecardiovascular disease.Method:To determine the peripheral blood ETlevels by means of radlo-immunlty for 34 cases ofnormal control(BC),34 cases of acute myocardiacinfarction(AMI),43 cases of coronary disease(CHD),25cases of hypertension(HT)and 21 cases ofcongestive heart failure(CHF).Result:the plasma ET levels of AMI,HT andCHF groups are much higher than that of thenormal control(P∠0.01),but the levels of CHD groupand normal group have no obvious difference.Theplasma ET level of AMI and CHF groups indifferent heart classify and the ET level of HTgroups are tend to go up as the disease isexacerbation(P∠0.01).Conclution:The plasma ET density has a closerelationship with the physiopathologic progress ofangiocardiopathy. | Department of Cardiology,the China-Japan Friandahip Hospital.Gao Yan Sha Li xiao Ge Chong Hun Du Ying | 1998 | 中国介入心脏病学杂志1998，6，4： | 1 |
| 17 | Economical Analysis on the Causes and Effects of the "Shell" Resource of the Professional Football Clubs in China显示文摘 | Sha Ge Enjun Wu Yue Wang | 2006 | Chinese Business Review2006，5，7： | 0 |
| 18 | Apolipoprotein C1 promotes glioblastoma tumorigenesis by reducing KEAP1/NRF2 and CBS-regulated ferroptosis显示文摘Glioblastoma(GBM),a malignant brain tumor,is a world-wide health problem because of its poor prognosis and high rates of recurrence and mortality.Apolipoprotein C1(APOC1)is the smallest of apolipoproteins,implicated in many diseases.Recent studies have shown that APOC1 promotes tumorigenesis and development of several types of cancer.In this study we investigated the role of APOC1 in GBM tumorigenesis.Using in silico assays we showed that APOC1 was highly expressed in GBM tissues and its expression was closely related to GBM progression.We showed that APOC1 protein expression was markedly increased in four GBM cell lines(U251,U138,A172 and U87)compared to the normal brain glia cell lines(HEB,HA1800).In U251 cells,overexpression of APOC1 promoted cell proliferation,migration,invasion and colony information,which was reversed by APOC1 knockdown.APOC1 knockdown also markedly inhibited the growth of GBM xenografts in the ventricle of nude mice.We further demonstrated that APOC1 reduced ferroptosis by inhibiting KEAP1,promoting nuclear translocation of NRF2 and increasing expression of HO-1 and NQO1 in GBM cells.APOC1 also induced ferroptosis resistance by increasing cystathionine beta-synthase(CBS)expression,which promoted trans-sulfuration and increased GSH synthesis,ultimately leading to an increase in glutathione peroxidase-4(GPX4).Thus,APOC1 plays a key role in GBM tumorigenesis,conferring resistance to ferroptosis,and may be a promising therapeutic target for GBM. | Xiang-jin Zheng Wen-lin Chen Jie Yi Wan Li Jin-yi Liu Wei-qi Fu Li-wen Ren Sha Li Bin-bin Ge Yi-hui Yang Yi-zhi Zhang Hong Yang Guan-hua Du Yu Wang Jin-hua Wang | 2022 | Acta Pharmacologica Sinica2022，43，11： | 0 |
| 19 | Fibroblast growth factor 21 inhibits ferroptosis following spinal cord injury by regulating heme oxygenase-1显示文摘Interfering with the ferroptosis pathway is a new strategy for the treatment of spinal cord injury.Fibroblast growth factor 21 can inhibit ferro ptosis and promote neurofunctional recovery,while heme oxygenase-1 is a regulator of iron and reactive oxygen species homeostasis.The relationship between heme oxygenase-1and ferroptosis remains controve rsial.In this study,we used a spinal co rd injury rat model to show that the levels of fibroblast growth factor 21 in spinal co rd tissue decreased after spinal cord injury.In addition,there was a significant aggravation of ferroptosis and a rapid increase in heme oxygenase-1 expression after spinal cord injury.Furthe r,heme oxygenase-1 aggravated fe rroptosis after spinal cord injury,while fibroblast growth factor 21 inhibited fe rroptosis by downregulating heme oxygenase-1.Thus,the activation of fibroblast growth factor 21 may provide a potential treatment for spinal co rd injury.These findings could provide a new potential mechanistic explanation for fibroblast growth factor 21 in the treatment of spinal cord injury. | Qi Gu Weiping Sha Qun Huang Jin Wang Yi Zhu Tianli Xu Zhenhua Xu Qiancheng Zhu Jianfei Ge Shoujin Tian Xiaolong Lin | 2024 | Neural Regeneration Research2024，19，7： | 0 |
| 20 | Author Correction:Apolipoprotein C1 promotes glioblastoma tumorigenesis by reducing KEAP1/NRF2 and CBS-regulated ferroptosis显示文摘During our recent check of our published article entitled“Apolipoprotein C1 promotes glioblastoma tumorigenesis by reducing KEAP1/NRF2 and CBS-regulated ferroptosis”in Acta Pharmacologica Sinica,we found that there was a mistake in Fig.2.We apologized that the representative image of Transwell(Fig.2e)appeared incorrectly.The image of U87-siAPOC1-1 in Migration present incorrect accidentally.The correct image is presented and the statistics of U87-siAPOC1-1 group have also been corrected.The authors apologize for any inconvenience caused to the journal and readers. | Xiang-jin Zheng Wen-lin Chen Jie Yi Wan Li Jin-yi Liu Wei-qi Fu Li-wen Ren Sha Li Bin-bin Ge Yi-hui Yang Yi-zhi Zhang Hong Yang Guan-hua Du Yu Wang Jin-hua Wang | 2022 | Acta Pharmacologica Sinica2022，43，11： | 0 |
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