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| 1 | Defining the advantages and exposing the limitations of endoscopic variceal ligation in controlling acute bleeding and achieving complete variceal eradication显示文摘BACKGROUND Bleeding esophageal varices(BEV)is a potentially life-threatening complication in patients with portal hypertension with mortality rates as high as 25%within six weeks of the index variceal bleed.After control of the initial bleeding episode patients should enter a long-term surveillance program with endoscopic intervention combined with non-selectiveβ-blockers to prevent further bleeding and eradicate EV.AIM To assess the efficacy of endoscopic variceal ligation(EVL)in controlling acute variceal bleeding,preventing variceal recurrence and rebleeding and achieving complete eradication of esophageal varices(EV)in patients who present with BEV.METHODS A prospectively documented single-center database was used to retrospectively identify all patients with BEV who were treated with EVL between 2000 and 2018.Control of acute bleeding,variceal recurrence,rebleeding,eradication and survival were analyzed using Baveno assessment criteria.RESULTS One hundred and forty patients(100 men,40 women;mean age 50 years;range,21-84 years;Child-Pugh grade A=32;B=48;C=60)underwent 160 emergency and 298 elective EVL interventions during a total of 928 endoscopy sessions.One hundred and fourteen(81%)of the 140 patients had variceal bleeding that was effectively controlled during the index banding procedure and never bled again from EV,while 26(19%)patients had complicated and refractory variceal bleeding.EVL controlled the acute sentinel variceal bleed during the first endoscopic intervention in 134 of 140 patients(95.7%).Six patients required balloon tamponade for control and 4 other patients rebled in hospital.Overall 5-d endoscopic failure to control variceal bleeding was 7.1%(n=10)and four patients required a salvage transjugular intrahepatic portosystemic shunt.Index admission mortality was 14.2%(n=20).EV were completely eradicated in 50 of 111 patients(45%)who survived>3 mo of whom 31 recurred and 3 rebled.Sixteen(13.3%)of 120 surviving patients subsequently had 21 EV rebleeding episodes and 10 patients bled from other sources after discharge from hospital.Overall rebleeding from all sources after 2 years was 21.7%(n=26).Sixty-nine(49.3%)of the 140 patients died,mainly due to liver failure(n=46)during follow-up.Cumulative survival for the 140 patients was 71.4%at 1 year,65%at 3 years,60%at 5 years and 52.1%at 10 years.CONCLUSION EVL was highly effective in controlling the sentinel variceal bleed with an overall 5-day failure to control bleeding of 7.1%.Although repeated EVL achieved complete variceal eradication in less than half of patients with BEV,of whom 62%recurred,there was a significant reduction in subsequent rebleeding. | Jake Krige Eduard Jonas Urda Kotze Christo Kloppers Karan Gandhi Hisham Allam Marc Bernon Sean Burmeister Mashiko Setshedi | 2020 | World Journal of Gastrointestinal Endoscopy2020，12，10： | 10 |
| 2 | The composition of magmatic Ni-Cu-(PGE) sulfide deposits in the Tati and Selebi-Phikwe belts of eastern Botswana显示文摘 | W. D. Maier S.-J. Barnes G. Chinyepi J. M. Barton B. Eglington I. Setshedi | 2008 | Mineralium Deposita2008，，3： | 1 |
| 3 | Acetaldehyde Adducts in Alcoholic Liver Disease显示文摘 | Mashiko Setshedi Jack R. Wands Suzanne M. de la Monte | 2010 | Oxidative Medicine and Cellular Longevity2010，，3： | 1 |
| 4 | Use ofthiopurines in the treatment of inflammatory bowel disease is associated with an increased risk of non- melanoma skin cancer in an at-risk population: a cohort study 显示文摘 | Setshedi M Epstein D Winter TA | 2012 | J Gastroenterol Hepatol2012，27，： | 1 |
| 5 | Exfoliated polypyrrole- organically modified montmorillonite clay nanocomposite as a potential adsorbent for Cr(Ⅵ) removal显示文摘 | Setshedi K Z Bhaumik M Songwane S | 2013 | Chemical Engineering Journal2013，222，： | 1 |
| 6 | Acetaldehyde adducts in alcoholic liver disease显示文摘 | Setshedi M Wands JR Monte SM | 2010 | Oxid Med Cell Longev2010，3，3： | 1 |
| 7 | Ceramide-Mediated Insulin Resistance and Impairment ofCognitive-Motor Functions显示文摘 | Suzanne M. de laMonte Ming Tong VanAnh Nguyen Mashiko Setshedi Lisa Longato Jack R. Wands | 2010 | Journal of Alzheimer’s Disease2010，，3： | 1 |
| 8 | Limited therapeutic effect of N-acetylcysteine on hepatic insulin resistance in an experimental model of alcohol-induced steatohepatitis显示文摘 | Setshedi M Longato L Petersen D R | 2011 | Alcohol Clin Exp Res2011，35，12： | 1 |
| 9 | Chromium (VI) removal from water using fixed bed column of polypyrrole/ Fe3O4 nanocomposite显示文摘 | Bhaumik M Setshedi K Maity A | 2013 | Separation and Purification Tech- nology2013，110，： | 1 |
| 10 | Resection of complex pancreatic injuries: Benchmarking postoperative complications using the Accordion classification显示文摘AIM To benchmark severity of complications using the Accordion Severity Grading System(ASGS) in patients undergoing operation for severe pancreatic injuries. METHODS A prospective institutional database of 461 patients with pancreatic injuries treated from 1990 to 2015 was reviewed. One hundred and thirty patients with AAST grade 3, 4 or 5 pancreatic injuries underwent resection(pancreatoduodenectomy, n = 20, distal pancreatectomy, n = 110), including 30 who had an initial damage controllaparotomy(DCL) and later definitive surgery. AAST injury grades, type of pancreatic resection, need for DCL and incidence and ASGS severity of complications were assessed. Uni-and multivariate logistic regression analysis was applied. RESULTS Overall 238 complications occurred in 95(73%) patients of which 73% were ASGS grades 3-6. Nineteen patients(14.6%) died. Patients more likely to have complications after pancreatic resection were older, had a revised trauma score(RTS) < 7.8, were shocked on admission, had grade 5 injuries of the head and neck of the pancreas with associated vascular and duodenal injuries, required a DCL, received a larger blood transfusion, had a pancreatoduodenectomy(PD) and repeat laparotomies. Applying univariate logistic regression analysis, mechanism of injury, RTS < 7.8, shock on admission, DCL, increasing AAST grade and type of pancreatic resection were significant variables for complications. Multivariate logistic regression analysis however showed that only age and type of pancreatic resection(PD) were significant. CONCLUSION This ASGS-based study benchmarked postoperative morbidity after pancreatic resection for trauma. The detailed outcome analysis provided may serve as a reference for future institutional comparisons. | Jake E Krige Eduard Jonas Sandie R Thomson Urda K Kotze Mashiko Setshedi Pradeep H Navsaria Andrew J Nicol | 2017 | World Journal of Gastrointestinal Surgery2017，9，3： | 1 |
| 11 | Acetaldehyde adducts in alcoholic liver disease显示文摘 | Setshedi M Wands J R Monte S M | 2010 | Oxid Med Cell Longev2010，，3： | 1 |
| 12 | Ceramide inhibitors and PPAR agonists ameliorate alcohol-induced steatohepatitis in an ex-vivo liver slice culture model显示文摘 | SETSHEDI M TONG M FENG D | 2010 | Hepatology2010，52，1： | 1 |
| 13 | Acetaldehyde adducts in alcoholic liver disease显示文摘 | Setshedi M Wands JR Monte SM | | 0，，04： | 1 |
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