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| 1 | Defining the advantages and exposing the limitations of endoscopic variceal ligation in controlling acute bleeding and achieving complete variceal eradication显示文摘BACKGROUND Bleeding esophageal varices(BEV)is a potentially life-threatening complication in patients with portal hypertension with mortality rates as high as 25%within six weeks of the index variceal bleed.After control of the initial bleeding episode patients should enter a long-term surveillance program with endoscopic intervention combined with non-selectiveβ-blockers to prevent further bleeding and eradicate EV.AIM To assess the efficacy of endoscopic variceal ligation(EVL)in controlling acute variceal bleeding,preventing variceal recurrence and rebleeding and achieving complete eradication of esophageal varices(EV)in patients who present with BEV.METHODS A prospectively documented single-center database was used to retrospectively identify all patients with BEV who were treated with EVL between 2000 and 2018.Control of acute bleeding,variceal recurrence,rebleeding,eradication and survival were analyzed using Baveno assessment criteria.RESULTS One hundred and forty patients(100 men,40 women;mean age 50 years;range,21-84 years;Child-Pugh grade A=32;B=48;C=60)underwent 160 emergency and 298 elective EVL interventions during a total of 928 endoscopy sessions.One hundred and fourteen(81%)of the 140 patients had variceal bleeding that was effectively controlled during the index banding procedure and never bled again from EV,while 26(19%)patients had complicated and refractory variceal bleeding.EVL controlled the acute sentinel variceal bleed during the first endoscopic intervention in 134 of 140 patients(95.7%).Six patients required balloon tamponade for control and 4 other patients rebled in hospital.Overall 5-d endoscopic failure to control variceal bleeding was 7.1%(n=10)and four patients required a salvage transjugular intrahepatic portosystemic shunt.Index admission mortality was 14.2%(n=20).EV were completely eradicated in 50 of 111 patients(45%)who survived>3 mo of whom 31 recurred and 3 rebled.Sixteen(13.3%)of 120 surviving patients subsequently had 21 EV rebleeding episodes and 10 patients bled from other sources after discharge from hospital.Overall rebleeding from all sources after 2 years was 21.7%(n=26).Sixty-nine(49.3%)of the 140 patients died,mainly due to liver failure(n=46)during follow-up.Cumulative survival for the 140 patients was 71.4%at 1 year,65%at 3 years,60%at 5 years and 52.1%at 10 years.CONCLUSION EVL was highly effective in controlling the sentinel variceal bleed with an overall 5-day failure to control bleeding of 7.1%.Although repeated EVL achieved complete variceal eradication in less than half of patients with BEV,of whom 62%recurred,there was a significant reduction in subsequent rebleeding. | Jake Krige Eduard Jonas Urda Kotze Christo Kloppers Karan Gandhi Hisham Allam Marc Bernon Sean Burmeister Mashiko Setshedi | 2020 | World Journal of Gastrointestinal Endoscopy2020,12,10: | 10 |
| 2 | Gas movements in front of flames propagating across methanol显示文摘 | Hirano T Suzuki T Mashiko I | 1980 | Combustion Science and Tech- nology1980,,22: | 1 |
| 3 | A new look at criteria for damage control surgery显示文摘 | Matsumoto H Mashiko K Sakamoto Y | 2010 | J Nippon Med Sch2010,77,1: | 1 |
| 4 | Effects of exer- cise on thephysical condition of college rugby players during summer trainingcamp显示文摘 | Mashiko T Umeda T Nakaji S | 2004 | Br J Sports Med2004,38,2: | 1 |
| 5 | A single target is sufficient to account for the biological effects of the A-factor receptor protein of Streptomyces griseus显示文摘 | Kato JY Miyahisa I Mashiko M | 2004 | Journal of Bacteriology2004,186,7: | 1 |
| 6 | Psychological distress after the Great East Japan Earthquake and Fukushima Daiichi Nuclear Power Plant accident : Results of a mental lmalth and lifestyle survey through the Fukushima Health Management Survey in FY2011 and FY2012 显示文摘 | Yabe H Suzuki Y Mashiko H | 2014 | Fukushima J Med Sci2014,60,1: | 1 |
| 7 | A Single Target Is Sufficient To Account for the Biological Effects of the A-Factor Receptor Protein of Streptomyces griseus显示文摘 | Kato Jun-ya Ikuo Miyahisa Mari Mashiko | 2004 | J Bacteriol2004,186,: | 1 |
| 8 | Development of three-dimensional hollow elastic model for cerebral aneurysm clipping simulation enabling rapid and low cost prototyping 显示文摘 | Mashiko T Otani K Kawano R | 2015 | World Neurosurg2015,83,3: | 1 |
| 9 | Ischemic preconditioning blocks BAD translocation,Bcl-x L cleavage,and large channel activity in mitochondria of postischemic hippocampal neurons显示文摘 | Miyawaki T Mashiko T Ofengeim D | 2008 | Proc Natl Acad Sci USA2008,105,12: | 1 |
| 10 | A criteria for damage control surgery in severe hepatic injury显示文摘 | Sakamoto Yuichiro Mashiko Kunihiro | 2005 | J Jpn Assoc Surg Trauma2005,19,4: | 1 |
| 11 | Small unruptured cerebral aneurysms presenting with oculomotor nerve palsy 显示文摘 | Yanaka K Matsumaru Y Mashiko R | 2003 | Neurusurgery2003,52,2: | 1 |
| 12 | Mutational analysis of TGF-beta type Ⅱ receptor,Smad2,Smad3,Smad4,Smad6 and Smad7 genes in colorectal cancer显示文摘 | Fukushima T Mashiko M Takita K | 2003 | J Exp Clin Cancer Res2003,22,2: | 1 |
| 13 | Characterization of neuropeptide Y (NPY) Y5 receptor-mediated obesity in mice: chronic intracerebroventricular infusion of D-Trp34NPY显示文摘 | MASHIKO S ISHIHARA A IWAASA H | 2003 | Endocrinology2003,144,: | 1 |
| 14 | Generation of isolated attosecond pulses with 20 to 28 femtosecond lasers显示文摘 | Feng x Gilbertson S Mashiko H | 2009 | Phys Rev Lett2009,103,18: | 1 |
| 15 | Derivation of populations with different-sized eggs in the palaemonid prawn Maerobrachium nipponense 显示文摘 | Mashiko Kazuo Numachi Ken-iehi | 2000 | JCrustaeBiol2000,20,1: | 1 |
| 16 | Cloning of the kanamycin resistance gene from a kanamycin-producing Streptomyces species 显示文摘 | Nakano M M Mashiko H Ogawara H | 1984 | J Bacteriol1984,157,1: | 1 |
| 17 | Systemic inflammatory response syndrome score at admission predicts injury severity, organ damage and serum neutrophil elastase production in trauma patients显示文摘 | SAKALNOTO Y MASHIKO K MATSUMOTO H | 2010 | J Nippon Med Sch2010,77,: | 1 |
| 18 | Characterization of Neuropeptide Y (NPY) Y5 Receptor-Mediated Obesity in Mice:Chronic Intracerebroventricular Infusion of D-Trp34NPY显示文摘 | Ishihara A Iwaasa H | 2003 | Endocrinology2003,144,: | 1 |
| 19 | Derivation of populations with different-sized eggs in the palaernonid prawn Macrobrachium nipponense 显示文摘 | Mashiko Kazuo Numachib Ken-ichi | 2000 | J Crust Biol2000,20,1: | 1 |
| 20 | A neuropeptide Y Y5 antagonist selectively ameliorates body weight gain and associated parameters in diet-induced obese mice显示文摘 | Kanatani A Mashiko S | 2006 | PNAS2006,103,: | 1 |