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| 1 | Screening and Surveillance for the Early Detection of Colorectal Cancer and Adenomatous Polyps, 2008: A Joint Guideline From the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology显示文摘 | Bernard Levin David A. Lieberman Beth McFarland Kimberly S. Andrews Durado Brooks John Bond Chiranjeev Dash Francis M. Giardiello Seth Glick David Johnson C. Daniel Johnson Theodore R. Levin Perry J. Pickhardt Douglas K. Rex Robert A. Smith Alan Thorson S | 2008 | Gastroenterology2008，，5： | 8 |
| 2 | Osteopontin is an important mediator of alcoholic liver disease via hepatic stellate cell activation显示文摘AIM: To investigate over-expression of Osteopontin(OPN) pathway expression and mechanisms of action in human alcoholic liver disease(ALD), in vivo and in vitro acute alcohol models. METHODS: OPN pathway was evaluated in livers from patients with progressive stages of human ALD and serum from drinkers with and without liver cirrhosis. In vitro stellate LX2 cells exposed to acute alcohol and in vivo in acute alcoholic steatosis mouse models were also investigated for OPN pathway expression and function. WT and OPN-/- mice were administered an acute dose of alcohol and extent of liver injury was examined by histopathology and liver biochemistry after 16-24 h. The causative role of OPN was studied in OPN knockout animals and in vitro in stellate LX2 cells, utilizing siRNA, aptamer and neutralizing antibodies to block OPN and OPN pathway. OPN pathway expression and downstream functional consequences were measured for signaling by Western blotting, plasmin activation by spectrophotometric assays and cell migration by confocal imaging and quantitation. RESULTS: OPN expression positively correlated with disease severity in patients with progressive stages of ALD. In vivo, associated with alcoholic steatosis, a single dose of acute alcohol significantly increased hepatic OPN mRNA and protein, and a cleaved OPN form in a dose dependent manner. OPN mRNA and secreted OPN also increased in parallel with activation of LX2 stellate cells within 4 h of a single dose of alcohol. Expression of OPN receptors, αvβ3-integrin and CD44, increased in human ALD, and in vivo and in vitro with alcohol administration. This was accompanied by downstream phosphorylation of Akt and Erk, increased mRNA expression of several fibrogenesis, fibrinolysis and extracellular matrix pathway genes, plasmin activation and hepatic stellate cell(HSC) migration. Inhibition of OPN and OPN-receptor mediated signaling partially inhibited alcohol-induced HSC activation, plasmin activity and cell migration. CONCLUSION: OPN is a key mediator of the alcoholinduced effects on hepatic stellate cell functions and liver fibrogenesis. | Devanshi Seth Alastair Duly Paul C Kuo Geoffrey W McCaughan Paul S Haber | 2014 | World Journal of Gastroenterology2014，20，36： | 5 |
| 3 | Dyslipidemia management in primary prevention of cardiovascular disease:Current guidelines and strategies显示文摘Cardiovascular disease is the leading cause of death in the United States. In 2010, the Centers for Disease Control and Prevention estimated that $444 billion was spent on cardiovascular diseases alone, about $1 of every $6 spent on health care. As life expectancy continues to increase, this annual cost will also increase, making costeffective primary prevention of cardiovascular disease highly desirable. Because of its role in development of atherosclerosis and clinical events, dyslipidemia management is a high priority in cardiovascular prevention. Multiple major dyslipidemia guidelines have been published around the world recently, four of them by independent organizations in the United States alone. They share the goal of providing clinical guidance on optimal dyslipidemia management, but guidelines differ in their emphasis on pharmacotherapy, stratification of groups, emphasis on lifestyle modification, and use of a fixed target or percentage reduction in low density lipoprotein cholesterol. This review summarizes eight major guidelines for dyslipidemia management and considers the basis for their recommendations. Our primary aim is to enhance understanding of dyslipidemia management guidelines in patient care for primary prevention of future cardiovascular risk. | Aditya D Hendrani Tolulope Adesiyun Renato Quispe Steven R Jones Neil J Stone Roger S Blumenthal Seth S Martin | 2016 | World Journal of Cardiology2016，8，2： | 5 |
| 4 | 食物是良药:将食物和营养融入医疗保健服务的行动显示文摘Sarah Downer及其同事探讨在医疗保健服务体系中将食品和营养纳入膳食相关疾病的预防、管理和治疗的新举措。与膳食相关的慢性病的全球流行,促使人们尝试将改善饮食作为患者医疗和护理的正规举措。 | Sarah Downer Seth A Berkowitz Timothy S Harlan Dana Lee Olstad Dariush Mozaffarian 冯琳(译) 武阳丰(校) | 2021 | 英国医学杂志中文版2021，24，4： | 2 |
| 5 | Enhanced survival and function of neural stem cells-derived dopaminergic neurons under influence of olfactory ensheathing cells in parkinsonian rats 显示文摘 | Shukla S Chaturvedi RK Seth K | 2009 | J Neurochem2009，109，2： | 1 |
| 6 | Percutaneous intracoronary cellular cardiomyoplasty for nonischemic cardiomyopathy:clinical and histopathological results:the first-in-man ABCD (Autologous Bone Marrow Cells in Dilated Cardiomyopathy) trial显示文摘 | Seth S Narang R Bhargava B | | 0，，11： | 1 |
| 7 | Tissue eosi-nophilia correlates strongly with poor prognosis in nodularsclerosing Hodgkin ’ S disease,allowing for known prognosticfactors显示文摘 | von Wasielewski R Seth S Franklin J | 2000 | Blood2000，95，4： | 1 |
| 8 | Service Quality Models: A Review显示文摘 | SETH N S G DESHMUKH P VRAT | 2005 | The International Journal of Quality b-Reliability Management2005，66，： | 1 |
| 9 | Influence of surfactants treatment on silver powder and its thick films 显示文摘 | RANE S B SETH T PHATAK G J | 2003 | Mater Lett2003，57，20： | 1 |
| 10 | 显示文摘 | Seth M L Raychaudhuri S P Investigations on the relationship of new brinjal mosaic virus and its vector Aphis gossypii Glov | 1977 | Acta Botanica Indica1977，5，2： | 1 |
| 11 | A framework for measurement of quality of service in supply chains 显示文摘 | Seth N Deshmukh S G Vrat P | 2006 | Supply Chain Management2006，11，1： | 1 |
| 12 | Removal of nutrients and Metals by Constructed and Naturally Created Wetlands in the Las Vegas Valley,Nevada显示文摘 | Achyut R Adhikari K A Seth A S Xiaoping Zhou | 2011 | Environ Monit Assess2011，，180： | 1 |
| 13 | A comprehensive assessment of memo- ry, delay aversion, timing,inhibition, decision making and variability in attention deficit hyperactivity disorder: advancing beyond the three- pathway models显示文摘 | Coghill DR Seth S Matthew K | 2014 | Psychol Med2014，44，9： | 1 |
| 14 | Diabetic Ketoacidosis-induced Hypertriglyceridemic Acute Pancreatitis Treated with PlasmapheresisRecipe for Biochemical Disaster Management显示文摘 | Seth A Rajpal S Saigal T | 2014 | Clin Med Insights Gastroenterol2014，7，： | 1 |
| 15 | Damage mechanics approach for bearing lifetime prognostics显示文摘 | Qiu J Zhang C Seth B B Liang S Y | 2002 | Mechanical Systems and Signal Processing2002，16，5： | 1 |
| 16 | Formability of steel in high velocity impact显示文摘 | Seth M Vohnout V J Daehn G S | 2005 | Journal of Materials Proceeding Technology2005，168，： | 1 |
| 17 | A potential treatment for pandemie influenza using siRNAs targeting conserved regions of in-fluenza A 显示文摘 | McSwiggen J A Seth S | 2008 | Expert Opin Biol Ther2008，8，3： | 1 |
| 18 | Developments in destructive and non-destructive pathway for selective desulfurization in oil-biorefining processes 显示文摘 | SETH L FARINELLI P DI MARTINO S | 1999 | Applied Microbiology and Biotechnology1999，52，1： | 1 |
| 19 | Beneficial effects of δ-adoncsyl-L0methionine on amino levulinic acid dehydratase,gintathione and lipid per oxidation during acute lead-ethanol administration in mice显示文摘 | Flora G J S Seth P K | 1999 | Alcohol1999，18，： | 1 |
| 20 | Muscle contributions to propulsion and support during running 显示文摘 | HAMNER S R SETH A DELP S L | 2010 | J Biom2010，43，14： | 1 |
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