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| 1 | Carbonic anhydrase enzymes Ⅱ, Ⅶ, Ⅸ and Ⅻ in colorectal carcinomas显示文摘AIM To investigate expression of four alpha-carbonic anhydrases(CAs) in colorectal carcinomas(CRC) and compare the results with patients' survival.METHODS Colorectal carcinoma samples from 539 CRC patients and control tissues were arranged as tissue microarrays and analyzed with antibodies against CA Ⅱ, CA Ⅶ, CA Ⅸ, and CA Ⅻ. Intensity and extent of staining were both scored from 0 to 3 in each sample. These enzyme expression levels were then correlated to patients' survival and clinicopathological parameters, which were tumor differentiation grade and stage, site of tumor, patients' age, and gender. Kaplan-Meier analysis and Cox regression hazard ratio model were used to analyze survival data. RESULTS CA Ⅱ and CA Ⅻ staining intensities correlated with patients' survival in that higher expression indicated poorer prognosis. In Cox regression analysis one unit increase in the CA Ⅱ intensity increased the hazard ratio to 1.19 fold(CI: 1.04-1.37, P = 0.009). A significant correlation was also found when comparing CA Ⅻ staining intensity with survival of CRC patients(HR = 1.18, 95%CI: 1.01-1.38, P = 0.036). The extent of CA Ⅻ immunostaining did not correlate to the patients' survival(P = 0.242, Kaplan-Meier analysis). A significant interaction between age group and extent of the CA Ⅱ staining was found. Increased extent of CA Ⅱ had a significant hazard ratio among patients 65 years and older(1.42, 95%CI: 1.16-1.73, P = 0.0006). No correlations were found between CA Ⅶ(intensity P = 0.566, extent P = 0.495, Kaplan-Meier analysis), or CA Ⅸ(intensity P = 0.879, extent P = 0.315, KaplanMeier analysis) immunostaining results and survival, or the other parameters. CONCLUSION The present findings indicate that CA Ⅱ and CA Ⅻ could be useful in predicting survival in CRC. | Pia Viikil? Antti J Kivel? Harri Mustonen Selja Koskensalo Abdul Waheed William S Sly Jaromir Pastorek Silvia Pastorekova Seppo Parkkila Caj Haglund | 2016 | World Journal of Gastroenterology2016，22，36： | 3 |
| 2 | Efficiency of the GSM-GPRS air interface for real-time IP traffic flows with and without packet dropping显示文摘 | Jahangir H Sarker Seppo J Halme | 2002 | Wireless Personal Communications2002，21，： | 2 |
| 3 | Delayless recursive differ- entiator with efficient noise attenuation for control instrumentation 显示文摘 | VALIVIITA S SEPPO OVASKA J | 1998 | Signal Processing1998，69，3： | 1 |
| 4 | Regular Aspirin-Use Preceding the Onset of Primary Intracerebral Hemorrhage Is an Independent Predictor for Death显示文摘 | Pertti S Mikko A Seppo J | 2006 | Stroke2006，37，1： | 1 |
| 5 | Delayless recursive differentiator with efficient noise attenuation for motion control applications显示文摘 | Sami Valiviita Ovaska Seppo J | 1998 | IECON Proceedings (Industrial Electronics Conference)1998，，3： | 1 |
| 6 | D dimer as an independent predictor for poor outcome after aneurysmal subarachnoid hemorrhage 显示文摘 | Seppo J Jari S | 2006 | Stroke2006，37，： | 1 |
| 7 | Regular aspirin-use preceding the on- set of primary intracerebral hemorrhage is an independent predic- tor for death显示文摘 | Pertti S Mikko A Seppo J | 2009 | Stroke2009，29，5： | 1 |
| 8 | Adhesion of some probiotic and dairy Lactobacillus strains to Caco-2 cell cultures显示文摘 | Elina M T Seppo J S | 1998 | Int J Food Microbiol1998，41，： | 1 |
| 9 | Polyomial predictive filtering on control instrumentation: a review显示文摘 | Valiviita Sami Ovaska Seppo J Vainio Olli | 1999 | IEEE Transaction on Industrial Electronics1999，46，5： | 1 |
| 10 | PCDD,PCDF,and PCB concentrations in human milk from two areas in Finland显示文摘 | TERTTU V SEPPO S JOUNI J J | 1997 | Chemosphere1997，34，12： | 1 |
| 11 | The effect of nicotine in combination with various dopaminergic drugs on nigrostriatal dopamine in rats显示文摘 | Sanna J Paula M P(a)ivi P Raimo KT Liisa A Seppo K | | 0，，： | 1 |
| 12 | The health effects of cultured milk productswilh viable and Non-viable bacterie显示文摘 | Arlhur C Seppo J | 1998 | Int Dairy1998，，8： | 1 |
| 13 | Exhaust Particulate Emissions of a Mustard Seed Oil Driven Tractor Engine 显示文摘 | SEPPO A Niemi TIMO T Murtonen MIKA J Lauren | 2002 | SAE Paper 0208662002，，： | 1 |
| 14 | Power Prediction in Mobile Communication Systems Using an Optimal Neural-Network Structure 显示文摘 | Xiao Ming Gao Xiao Zhi Gao Jarno M A Seppo J Ovaska | 1997 | IEEE Transactions on Neural Networks1997，8，6： | 1 |
| 15 | Industrial applications of soft computing: a review 显示文摘 | Dote Yasuhiko Ovaska Seppo J | 2001 | Proceedings of the IEEE2001，89，9： | 1 |
| 16 | Loading Using an Aluminium Compound 显示文摘 | Seppo K Siven Hannu J Manner | 2003 | Appita2003，56，6： | 1 |
| 17 | Adhesion of some probiotic and dairy Lactobacillus strains to Caco-2 cell cultures显示文摘 | Elina M Tuomola (née Lehto) Seppo J Salminen | 1998 | International Journal of Food Microbiology1998，，1： | 1 |
| 18 | Fertile wheat (Triticum aestivum L.) regenerants from protoplasts of embryogenic suspension culture显示文摘 | János Pauk Zoltán Kertész Barnabás Jenes László Purnhauser Outi Manninen Seppo Pulli Zoltán Barabás Dénes Dudits | 1994 | Plant Cell Tissue and Organ Culture1994，，1： | 1 |
| 19 | Thromboxane and prostacyclin biosynthesis in patients with acute spontaneous intraeerbral hemor rhage显示文摘 | Pertti S Seppo J Asko R | 2005 | ThromRes2005，115，5： | 1 |
| 20 | Ankle and foot injuries:analysis of MDCT findings显示文摘 | Ville V Martti J Seppo K | 2004 | AJR2004，183，3： | 1 |
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