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| 1 | Metallothionein:An overview显示文摘Metallothioneins (MTs) were discovered in 1957 by Margoshes and Vallee and identified as low-molecular weight and sulphydryl rich proteins. It is not surprising that most mammalian tissues contain age related basal levels of MTs since they are involved in metalloregulatory processes that include cell growth and multiplication. In an effort to understand the biology of this intriguing tumor, various biomarkers such as oncogenes, p53 tumor suppressor gene, waf 1 protein, proliferating cell nuclear antigen, telomerase, microsatellite markers and cytogenetic changes have been examined. One biomarker which has recently shown to be expressed in various human tumors but still less reported in carcinoma is MT. Immunohistochemical detection of MT proteins in cold acetone-fixed paraffin embedded liver sections was performed by the streptavidin-avidin-biotin immuno- peroxidase complex method. | N Thirumoorthy KT Manisenthil Kumar A Shyam Sundar L Panayappan Malay Chatterjee | 2007 | World Journal of Gastroenterology2007，13，7： | 21 |
| 2 | 罗格列酮单用或者与阿伐他汀联合使用对于2型糖尿病患者心血管疾病的非传统标志物的作用显示文摘 | Chu CS Lee KT Lee MY 菅鑫妍 | 2006 | 中国处方药2006，，6： | 13 |
| 3 | Investigation of hypoglycemic,hypolipidemic and antioxidant activities of aqueous extract of Terminalia paniculata bark in diabetic rats显示文摘Objective:To investigate the hypoglycemic,hypolipidemic and antioxidant activities of aqueous extract of Terminalia paniculata bark(AETPB) in streptozotocin(STZ)-mduced diabetic rats.Methods:Acute toxicity was studied in rats after the oral administration of AETPB to determine the dose to assess hypoglycemic activity.In rats,diabetes was induced by injection of STZ(60 mg/kg,i.p.) and diabetes was confirmed 72 h after induction,and then allowed for 14 days to stabilize blood glucose level.In diabetic rats,AETPB was orally given for 28 days and its effect on blood glucose and body weight was determined on a weekly basis.At the end of the experimental day,fasting blood sample was collected to estimate the haemoglobin(Hb),glycosylated haemoglobin(HbA1c),serum creatinine,urea,serum glutamate-pyruvate transaminase(SGPT),serum glutamate-oxaloacetate transaminase(SGOT) and insulin levels. The liver and kidney were collected to determine antioxidants levels in diabetic rats.Results: Oral administration of AETPB did not exhibit toxicity and death at a dose of 2000 mg/kg.AETPB treated diabetic rats significantly(P<0.001,P<0.01 and P<0.05) reduced elevated blood glucose, HbAlc,creatinine,urea,SGPT and SGOT levels when compared with diabetic control rats.The body weight,Hb,insulin and total protein levels were significantly(P<0.001,P<0.01 and P<0.05) increased in diabetic rats treated with AETPB compared to diabetic control rats.In diabetic rats, AETPB treatment significantly reversed abnormal status of antioxidants and lipid profile levels towards near normal levels compared to diabetic control rats.Conclusions:Present study results confirm that AETPB possesses significant hypoglycemic,hypolipidemic and antioxidant activities in diabetic condition. | Subramaniam Ramachandran Aiyalu Rajasekaran KT Manisenthilkumar | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，4： | 9 |
| 4 | 人体1型糖尿病中的关键免疫细胞显示文摘1型糖尿病患者胰岛β细胞被破坏与胰岛自身反应性T细胞之间的直接联系从未被证明,对诊断后的疾病进程也所知无几。最近美国科学家的研究第一次对此有了直接的证据。冷冻胰腺样本来自病程在1周到超过50年的45例死亡患者的遗体捐赠,14例非糖尿病患者对照样本,5例有自身抗体的非糖尿病患者样本,2例孕期糖尿病患者样本,以及6例2型糖尿病患者样本。系统检查样本的组织切片是否存在有足够胰岛素的β细胞、CD8阳性的胰岛病变和1型HLA过度表达。最后,对表达HLA-A2的样本的连续切片用四聚体染色法针对6种已知确定的与1型糖尿病有关的胰岛自身抗原进行CD8 T细胞反应性检查。在临床确诊后最长达8年的分组患者胰岛样本中单一和多种CD8 T细胞反应性都检测到了。1型糖尿病特有的1型HLA过度表达和胰岛炎等病理特征存在于一小部分病程很长的患者中。在受影响的器官中,胰岛病变持续存在,表现为不同程度的浸润和β细胞丢失。该研究为人体胰岛自身反应性提供了第一个直接证据并强调了发病历程的异质性和长期性。 | Coppieters KT Dotta F Amirian N | 2012 | 中国烧伤创疡杂志2012，24，3： | 9 |
| 5 | Antidiabetic,antihyperlipidemic and antioxidant potential of methanol extract of Tectona grandis flowers in streptozotocin induced diabetic rats显示文摘Objective:To investigate antidiabetic,antihyperlipidemic and antioxidant activity of methanol extract of Tectona grandis(T.grandis) flowers(METGF) in streplozotocin(STZ) induced diabetic rats to supports its traditional use.Methods:Acute toxicity study of METGF was carried out in rat to determine its dose for the antidiabetic study.Oral glucose tolerance test(OGTT) was performed to evaluate METGF effect on elevated blood glucose level.Diabetes was induced in rats by administration of STZ(60 mg/kg,ip.) and it was confirmed 72 h after induction.METGF was orally given to the diabetic rats up to 28 days and blood glucose level were estimated each week.On 28 day of the experiment,diabetic rats were sacrificed after the blood collection for the biochemical parameters analysis and liver,kidney was collected to determine antioxidants levels.Results: In acute toxicity,METGF did not show toxicity and death up to a dose 2 000 mg/kg in rats. Administration of METGF 100 and 200 mg/kg significantly(P<0.001) reduced blood glucose levels in OGTT and STZ-induced diabetic rats.Both doses of METGF treatment significantly(P<0.001, P<0.01 and P<0.05) increased body weight,serum insulin,haemoglobin(Hb) and total protein levels in diabetic rats.Also,MEGTF treatment reduced elevated glycosylated haemoglobin(HbA1c) and other biochemical parameters levels significantly(P<0.001) in diabetic rats.Altered lipid profiles and antioxidants levels were reversed to near normal in diabetic rats treated with METGF. Conclusions:These results concluded that METGF possesses antidiabetic,antihyperglycemic and antioxidant activity which supports its traditional use. | Subramaniani Ramachandran Aiyalu Rajasekaran KT Manisenthil Kumar | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，8： | 7 |
| 6 | Elderly healthcare service at the community health centers in the Pearl River Delta region,China显示文摘Objective:The recent population census showed China had officially become a graying society.In the meantime,China also faces a growing burden of non-communicable diseases.Since 2009,a series of policies have been implemented to enhance primary care at the community level.This study describes the elderly care services provided in the differently organized community health centers(CHCs).Methods:It covered 13 CHCs of six cities located within the Pearl River Delta(PRD)region.In-depth interviews were conducted with a total of 59 health administrators,CHC managers,and CHC doctors regarding elderly care.Results:The study found that accessibility of healthcare for elders has been improved due to the development of health insurance schemes as well as preferential policy to encourage the CHC utilization by the elderly.All the CHCs provide health examinations and chronic disease management to the permanent elderly within their catchment district.However,some preventative care such as fall prevention,immunization and mental health management are not provided.Conclusion:Key barriers include low capacity of health service providers in the CHCs,and a lack of government investment in CHCs.Our report provides an empirical evidence for the health care reform in China. | NAN YANG XIAOLIN WEI HAITAO LI ZHENZHEN ZHANG JAMIE RODAS SAMUEL YS WONG MARTIN CS WONG YANG GAO JIAJI WANG DONALD KT LI JINLING TANG SIAN GRIFFITHS | 2013 | Family Medicine and Community Health2013，1，1： | 5 |
| 7 | Ames试验研究鞣酸和相关化合物的毒性和抗突变性显示文摘[目的 ]Ames试验研究鞣酸和相关化合物抗突变作用。 [方法 ]应用平皿掺入和悬浮培养抗突变性方法 ,比较研究鞣酸和相关化合物在无抑制和抑制浓度减少 2 硝基芴 (2 NF)、4 硝基喹啉 1 氧化物 (4 NQO)和N 甲基 N 硝基 N 亚硝基胍 (MNNG)回复菌落数。 [结果 ]鞣酸和相关化合物月桂木立口 酸、鞣花酸、木立口 酸丙脂、木立口 酸甲脂、木立口 酸和儿茶素抑制Ames试验沙门氏菌菌株生长 ,这种抑制作用与减少Ames试验回复突变和诱发突变菌落数相关。应用悬浮培养方法 ,鞣酸和相关化合物在无抑制浓度和抑制浓度对 2 NF、4 NQO和MNNG无抗突变作用。 [结论 ]Ames试验悬浮培养法是研究抑菌剂类化合物抗突变有用方法 ,可区别由毒性和抗突变作用减少的回复菌落数。 | 周永贵 Chung KT | 2002 | 环境与职业医学2002，19，4： | 4 |
| 8 | 持续性红细胞生成素受体激活剂静脉给药在慢性肾脏病透析患者中纠正贫血的疗效、安全性和耐受性显示文摘目的评估持续性红细胞生成素受体激活剂(CERA)每2周1次静脉给药与红细胞生成素13(EPO-β)相比在慢性肾脏病(CKD)透析患者中纠正贫血的疗效和安全性。方法采用开放、随机、平行、阳性对照、多中心临床试验方法。正在接受血液透析或腹膜透析且8周内未接受红细胞生成刺激剂(ESA)治疗的CKD贫血成年患者,随机(1:1)接受CERA每2周1次静脉注射(CERA组,n=132例)或EPO-β每周3次静脉注射(EPO组,n=133例)持续治疗24周(包括16周纠正期和8周疗效评估期)。此后对达到目标血红蛋白(Hb)值(定义为首次给药后24周内在未输注红细胞的情况下,Hb≥110g/L且与基线值相比上升≥10g/L)的患者继续分别维持CERA或EPO-β治疗28周,以观察长期安全及耐受性。CERA的起始剂量为0.4μg/k。主要研究终点为前24周的Hb反应率及评估期(17-24周)Hb与基线值相比的变化。结果共计232例患者(87.5%)完成了前24周的治疗,198例患者(74.7%)完成了整个研究(52周)的治疗。CERA治疗组前24周的Hb反应率为87.12%[95%CI(80.2%-92.3%)]。根据其95%CI的下限高于60%(P〈0.01),认为CERA每2周1次静脉给药能有效纠正CKD贫血。符合方案(PP)人群中CERA组与EPO组评估期Hb相对基线变化的差异为-4.7g/L[95%CI(-7.38g/L-1.92g/L)]。根据其95%CI的下限大于预先设定的非劣效性界值-7.5g/L(P=0.0205),认为CERA纠正CKD贫血后维持Hb非劣效于EPO-β。在28周的延长期间两组的Hb水平均保持稳定。研究期间CERA组和EPO组的安全性结果相当,分别有50.0%及54.6%的患者报告了至少1件不良事件(AE),AE与研究人群的特征一致。结论在未接受ESA治疗的CKD透析患者中,每两周静脉注射1次CERA可有效纠正贫血,且纠正贫血后维持Hb非劣效于EPO-β治疗。CKD透析患者对于长期静脉注射给药CERA总体上耐受性良好。 | 钱家麒 陈楠 梅长林 刘文虎 侯凡凡 史伟 陈江华 陈香美 李文歌 顾勇 刘必成 丁小强 王莉 Philip KT LI 于凌博 田劲 | 2012 | 中华肾脏病杂志2012，28，11： | 3 |
| 9 | Collecting aerosol in airflow with a magnetically stabilized fluidized bed显示文摘A magnetically stabilized fluidized bed (MSB) is a highly efficient filter that takes the advantage of both fluidized beds and fixed beds. This paper presents the research to collect aerosol in airflow with a MSB. The filtering model of MSB is established with its parameters including magnetic field intensity, gas superficial velocity, average grain size, and bed height on the collection efficiency of MSB. The model is verified by experiments. | Gui, KT Zhang, H Shi, MH Xu, YQ | 2001 | Journal of Environmental Sciences2001，13，4： | 3 |
| 10 | 利用聚合物-软骨细胞复合物构建人耳状组织工程化软骨显示文摘采用自体软骨进行全外耳重建目前仍然是修复重建外科领域的难题之一。外科医生的目的在于制作一个与对侧耳外形相似的新耳,因此要求使用与外耳三维结构相同的可塑性支架。 进行全外耳重建的方法主要有两种:假体植入和自体软骨移植。虽然临床上多用自体软骨移植,但假体移植拥有更多的优点:采用硅橡胶或聚丙烯的假体植入不受供源限制,因预先塑形而节省手术时间,且具有恒定的预构形状。但这些植入物同样具有其它植入性假体的缺点:容易感染,耐久性差,存在异物排斥反应,许多材料尤其是硅橡胶可与受者发生免疫反应。 | 魏宽海 Vacanti JP Paige KT | 2000 | 中国创伤骨科杂志2000，2，4： | 3 |
| 11 | Response to strict and liberalized specific carbohydrate dietin pediatric Crohn's disease显示文摘AIM: To investigate the specific carbohydrate diet(SCD) as nutritional therapy for maintenance of remission in pediatric Crohn's disease(CD). METHODS: Retrospective chart review was conducted in 11 pediatric patients with CD who initiated the SCD as therapy at time of diagnosis or flare. Two groups defined as SCD simple(diet alone, antibiotics or 5-ASA) or SCD with immunomodulators(corticosteroids and/or stable thiopurine dosing) were followed for one year and compared on disease characteristics, laboratory values and anthropometrics.RESULTS: The mean age at start of the SCD was 11.8 ± 3.0 years(range 6.6-17.6 years) with five patients starting the SCD within 5 wk of diagnosis. Three patients maintained a strict SCD diet for the study period and the mean time for liberalization was 7.7 ± 4.0 mo(range 1-12) for the remaining patients. In both groups, hematocrit, albumin and ESR values improved while on strict SCD and appeared stable after liberalization(P-value 0.006, 0.002, 0.002 respectively). The majority of children gained in weight and height percentile while on strict SCD, with small loss in weight percentile documented with liberalization. CONCLUSION: Disease control may be attainable with the SCD in pediatric CD. Further studies are needed to assess adherence, impact on mucosal healing and growth. | Jennifer C Burgis Kaylie Nguyen KT Park Kenneth Cox | 2016 | World Journal of Gastroenterology2016，22，6： | 3 |
| 12 | Yeast and mammalian metallothioneins functionally substitute for yeast copper - zinc superoxide dismutase 显示文摘 | Tamai KT Gralla EB Ellerby LM | 1993 | Proc Natl Acad Sci USA1993，90，： | 2 |
| 13 | The distribution and ecology of Malassezia furfur and cutaneous bacteria on human skin显示文摘 | Leeming JP Notman PH Holland KT | 1989 | J Appl Bacteriol1989，67，： | 2 |
| 14 | Antipyretic,anti-inflammatory and analgesic properties of nilavembu kudineer choornam:a classical preparation used in the treatment of chikungunya fever显示文摘Objective:To investigate the efficacy of ethanolic extract of nilavembu kudineer choornam (EENKC) in inflammation,pain and fever using animal models to support its actions.Methods: Acute toxicity study of EENKC was performed in mice to fix the effective dose.The antipyretic, anti-inflammatory and analgesic activity of EENKC was evaluated in brewer’s yeast induced pyrexia in rats,carrageenan-induced inflammation in rats and acetic-acid induced writhing in mice model.Results:Acute toxicity revealed that EENKC didn’t show death and toxic signs up to 2 000 mg/kg.In brewer’s yeast induced pyrexia and carrageenan-induced inflammation EENKC at the doses of 200 and 400 mg/kg inhibited fever and inflammation significantly(P<0.01 and<0.05) compared to control animals.In mice,the number of writhing induced by acetic-acid was significantly(P<0.01) reduced after treatment with both the dose of EENKC than control animals. EENKC 200 mg/kg inhibits inflammation higher level in carrageenan-induced paw edema,but there is no significant difference when compared to indomethacin 10 mg/kg.Conclusions:The present findings revealed that EENKC possesses antipyretic,anti-inflammatory and analgesic activity which supports nilavembu kudineer choornam efficacy in chikungunya fever. | Anbarasu K Manisenthil Kumar KT Ramachandran S | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，10： | 2 |
| 15 | 低硫钢的性能和切削性显示文摘 | Hans.,KT 任民恩 | 1994 | 国外低合金钢(合金钢)1994，，14： | 2 |
| 16 | 大肠癌患者癌周淋巴结淋巴细胞酶活性研究显示文摘应用电镜酶细胞化学方法,对14例大肠癌患者癌周淋巴结副皮质T淋巴细胞酶活性进行了研究。结果表明:①ATP酶主要定位于淋巴细胞膜内侧,G-6-P酶主要定位于内质网及线粒体膜表面。大肠癌患者上述两种酶活性明显减弱。②5’-ND酶定位在内质网、线粒体膜等部位,大肠癌患者该酶活性明显增高。提示ATP酶与G-6-P酶活性下降可能是大肠癌患者细胞免疫机能降低的主要原因之一。 | 蔡玉文 Pa.,KT | 1996 | 中国肛肠病杂志1996，16，4： | 2 |
| 17 | E-Cadherin gene promoter hypermethylation in primary human gastric carcinomas显示文摘 | Tamura G Yin J Wang S Fleisher AS Zou T Abraham JM Kong D Smolinski KN Wilson KT James SP Silverberg SG Nishizuka S Terashima M Motoyama T Meltzer SJ | | 0，，： | 2 |
| 18 | Novel Permanent Magnet Motor Drives for Electric Vehicle显示文摘 | Chan CC Chau KT | 1996 | IEEE Transaction on Industrial Electronics1996，43，2： | 2 |
| 19 | Endothelial cell loss after 4 mm cataract surgery显示文摘 | Lavery KT McDermott ML Ernest PH | 1995 | J Cataract Refract Surg1995，21，3： | 2 |
| 20 | Evaluation of anti–inflammatory and analgesic potential of methanol extract of Tectona grandis flowers显示文摘 | S Ramachandran B Rajini kanth A Rajasekaran KT Manisenthil Kumar | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，，2： | 2 |
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