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| 1 | Functional magnetic resonance imaging of internet addiction in young adults显示文摘AIM: To report the results of functional magnetic resonance imaging(f MRI) studies pertaining internet addiction disorder(IAD) in young adults.METHODS: We conducted a systematic review on Pub Med, focusing our attention on f MRI studies involving adult IAD patients, free from any comorbid psychiatric condition. The following search words were used, both alone and in combination: f MRI, internet addiction, internet dependence, functional neuroimaging. The search was conducted on April 20^(th), 2015 and yielded 58 records. Inclusion criteria were the following: Articles written in English, patients' age ≥ 18 years, patients affected by IAD, studies providing f MRI results during resting state or cognitive/emotional paradigms. Structural MRI studies, functional imaging techniques other than f MRI, studies involving adolescents, patients with comorbid psychiatric, neurological or medical conditions were excluded. By reading titles and abstracts, we excluded 30 records. By reading the full texts of the 28 remaining articles, we identified 18 papers meeting our inclusion criteria and therefore included in the qualitative synthesis.RESULTS: We found 18 studies fulfilling our inclusion criteria, 17 of them conducted in Asia, and including a total number of 666 tested subjects. The included studies reported data acquired during resting state or different paradigms, such as cue-reactivity, guessing or cognitive control tasks. The enrolled patients were usually males(95.4%) and very young(21-25 years). The most represented IAD subtype, reported in more than 85% of patients, was the internet gaming disorder, or videogame addiction. In the resting state studies, the more relevant abnormalities were localized in the superior temporal gyrus, limbic, medial frontal and parietal regions. When analyzing the task related fmri studies, we found that less than half of the papers reported behavioral differences between patients and normal controls, but all of them found significant differences in cortical and subcortical brain regions involved in cognitive control and reward processing: Orbitofrontal cortex, insula, anterior and posterior cingulate cortex, temporal and parietal regions, brain stem and caudate nucleus.CONCLUSION: IAD may seriously affect young adults' brain functions. It needs to be studied more in depth to provide a clear diagnosis and an adequate treatment. | Gianna Sepede Margherita Tavino Rita Santacroce Federica Fiori Rosa Maria Salerno Massimo Di Giannantonio | 2016 | World Journal of Radiology2016，8，2： | 4 |
| 2 | Sustained attention in psychosis:Neuroimaging findings显示文摘To provide a systematic review of scientific literatureon functional magnetic resonance imaging(fMRI) stud-ies on sustained attention in psychosis. We searchedPubMed to identify fMRI studies pertaining sustainedattention in both affective and non-affective psycho-sis. Only studies conducted on adult patients using asustained attention task during fMRI scanning wereincluded in the final review. The search was conductedon September 10 th, 2013. 15 fMRI studies met our in-clusion criteria: 12 studies were focused on Schizophre-nia and 3 on Bipolar Disorder Type Ⅰ(BDI). Only halfof the Schizophrenia studies and two of the BDI stud-ies reported behavioral abnormalities, but all of themevidenced significant functional differences in brain re-gions related to the sustained attention system. Alteredfunctioning of the insula was found in both Schizophre-nia and BDI, and therefore proposed as a candidate trait marker for psychosis in general. On the other hand, other brain regions were differently impaired in affective and non-affective psychosis: alterations of cingulate cortex and thalamus seemed to be more common in Schizophrenia and amygdala dysfunctions in BDI. Neural correlates of sustained attention seem to be of great interest in the study of psychosis, highlight-ing differences and similarities between Schizophrenia and BDI. | Gianna Sepede Maria Chiara Spano Marco Lorusso Domenico De Berardis Rosa Maria Salerno Massimo Di Giannantonio Francesco Gambi | 2014 | World Journal of Radiology2014，6，6： | 2 |
| 3 | Efficacy and safety of fluoxetine monotherapy in bipolar depression: a systematic review显示文摘 | Martinotti G Sepede G Signorelli M | 2013 | Expert Opin Pharmacother2013，14，8： | 1 |
| 4 | Olanzapine augmentation in treatment-resistant panic disorder:a 12week,fixed-dose,open-label trial显示文摘 | Sepede G De Berardis D Gambi F | 2006 | J Clin Psychopharmaco12006，26，1： | 1 |
| 5 | Effect of mirtazapine on thyroid hormones in adult patients with major depression显示文摘 | Gambi F De Berardis D Sepede G | 2005 | Int J Immunopathol Pharmacol2005，18，4： | 1 |
| 6 | Effect of mirtazapine on thyroid hormones in adult patients with major depression显示文摘 | GAMBI F de BERARDIS D SEPEDE G | 2005 | Int J Immunopathol Pharmacol2005，18，4： | 1 |
| 7 | Psychophysical distress and alexithymic traits in chronic fatigue syndrome with and without comorbid depression显示文摘 | Sepede G Racciatti D Gorgoretti V | | 0，，04： | 1 |
| 8 | Agomelatine versus venlafaxine XR in the treatment of anhedonia in major depressive disorder: a pilot study显示文摘 | MARTINOTTI G SEPEDE G GAMBI F | 2012 | J Clin Psychopharmacol2012，32，4： | 1 |
| 9 | Bupropion as an Add-on Therapy in Depressed Bipolar Disorder Type I Patients With Comorbid Cocaine Dependence显示文摘 | Gianna Sepede Giuseppe Di lorio Matteo Lupi Fabiola Sarchione Tiziano Acciavatti Federica Fiori Rita Santacroce Giovanni Martinotti Francesco Gambi Massimo Di Giannantonio | 2014 | Clinical Neuropharmacology2014，，： | 1 |
| 10 | Elevated response of hu- man amygdala to neutral stimuli in mild post traumatic stress disorder:neural correlates of generalized emotional response显示文摘 | Brunetti M Sepede G Mingoia G | 2010 | Neuroscienee2010，168，3： | 1 |
| 11 | Elevated response of human amygdala to neutral stimuli in mild post traumatic stress disorder; neural correlates of generalized emotional response显示文摘 | Brunetti M Sepede C Mingoia G | 2010 | Neuroscience2010，14，168： | 1 |
| 12 | Agomelatine versus venlafaxine XR in the treatment of anhedonia in major depressive disorder: a pilot study 显示文摘 | MARTINOTFI G SEPEDE G GAMBI F | 2012 | J Clin Psychopharma- col2012，32，4： | 1 |
| 13 | Impaired sustained attention in euthymic bipolar disorder patients and non‐affected relatives: an fMRI study显示文摘 | Gianna Sepede Domenico De Berardis Daniela Campanella Mauro Gianni Perrucci Antonio Ferretti Nicola Serroni Francesco Saverio Moschetta Cosimo Del Gratta Rosa Maria Salerno Filippo Maria Ferro Massimo Di Giannantonio Marco Onofrj Gian Luca Romani Francesc | 2012 | Bipolar Disorders2012，，7： | 1 |
| 14 | Effect of nfirtazap- ine on thyroid hormones in adult patients with major depression 显示文摘 | GAMBI F DE BERARDIS D SEPEDE G | 2005 | Int J Immunopathol Pharmacol2005，18，4： | 1 |
| 15 | Agomelatine versus ven- lafaxine XR in the treatment of anhedonia in major depressive disorder: a pilot study显示文摘 | Martinotti G Sepede G Gambi F | 2012 | J Clin Psyehopharmacol2012，32，4： | 1 |
| 16 | Agomelatineversus venlafaxine XR in the treatment of anhedonia inmajor depressive disorder : a pilot study 显示文摘 | MARTINOTTI G SEPEDE G GAMBI F | 2012 | J ClinPsychopharmacol2012，32，4： | 1 |
| 17 | Psychophysical distress and alexithymic traits in chronic fatigue syndrome with and without comorbid depression 显示文摘 | Sepede G Racciatti D Gorgoretti V | 2011 | Int J Immunopathol Pharmacol2011，24，4： | 1 |
| 18 | Craving variations in patients with substance use disorder and gambling during COVID-19 lockdown:The Italian experience显示文摘BACKGROUND Following the development of the coronavirus disease-2019(COVID-19)pandemic in Italy,a strict lockdown was imposed from March 9 to May 5,2020.The risks of self-medication through alcohol or psychoactive substance abuse were increased,as well as the tendency to adopt pathological behaviors,such as gambling and internet addiction.AIM To evaluate the impact of the COVID-19 pandemic and associated containment measures on craving in a group of patients suffering from substance use disorder and/or gambling disorder who were in treatment in outpatient units or in residency programs as inpatients.METHODS One hundred and fifty-three patients completed a structured questionnaire evaluating craving and other behaviors using a visual analogue scale(VAS).Forty-one subjects completed a pencil and paper questionnaire during the interview.The clinician provided an online questionnaire to 112 patients who had virtual assessments due to lockdown restrictions.Statistical analyses were performed using Statistica version 8.0.Quantitative parameters are presented as the mean±SD and qualitative parameters as number and percentage per class.The Kolmogorov-Smirnov test was used to check for normality of distributions.Analysis of variance and Duncan post hoc test were employed to analyze differences among subgroup means.The associations between variables were measured using Pearson's correlation.A P value of<0.05 was considered significant.RESULTS The variation in craving between the present and the month before showed VASrelated reductions of craving in 57%,increases in 24%,and no significant change in 19%of the sample.The level of craving was significantly higher(F=4.36;P<0.05)in outpatients(n=97;mean=3.8±3.1)living in their own home during the quarantine compared with inpatients(n=56;mean=2.8±2.8)in residential programs.Craving for tetrahydrocannabinol was the greatest(4.94,P<0.001)among various preferred substances.CONCLUSION The unexpected result of this study may be explained by a perceived lack of availability of substances and gambling areas and/or decreased social pressure on a subject usually excluded and stigmatized,or the acquisition of a new social identity based on feelings of a shared common danger and fate that overshadowed the sense of exclusion and rejection in the abuser. | Maria Chiara Alessi Giovanni Martinotti Domenico De Berardis Antonella Sociali Chiara Di Natale Gianna Sepede Daniela Pia Rosaria Cheffo Laura Monti Pietro Casella Mauro Pettorruso Stefano Sensi Massimo Di Giannantonio | 2022 | World Journal of Clinical Cases2022，10，3： | 0 |
| 19 | Hypomanic/manic switch after transcranial magnetic stimulation in mood disorders:A systematic review and meta-analysis显示文摘BACKGROUND Nowadays there is an increasing use of transcranial magnetic stimulation(TMS)both in neurological and psychiatric fields.After Food and Drug Administration approval of TMS for the therapy of treatment-resistant depression,TMS has been widely used in the context of mood disorders(MD).However,growing reports regarding the possibility of developing hypomanic/manic switch(HMS)have generated concern regarding its use in MDs.AIM To investigate the actual risk of developing HMS due to TMS in the treatment of MD.METHODS We led our research on PubMed,Scopus and Web of Science on March 22,2020,in accordance to the PRISMA guidelines for systematic review.Only double blind/single blind studies,written in English and focused on the TMS treatment of MD,were included.A meta-analysis of repetitive TMS protocol studies including HMS was conducted using RevMan 5.4 software.The assessment of Risk of Bias was done using Cochrane risk of bias tool.This protocol was registered on PROSPERO with the CRD42020175811 code.RESULTS Twenty-five studies were included in our meta-analysis:Twenty-one double blind randomized controlled trials(RCT)and four single blind-RCT(no.of subjects involved in active stimulation=576;no.of subjects involved in sham protocol=487).The most frequently treated pathology was major depressive episode/major depressive disorder,followed by resistant depression,bipolar depression and other MD.The majority of the studies used a repetitive TMS protocol,and the left dorsolateral prefrontal cortex was the main target area.Side effects were reported in eight studies and HMS(described as greater energy,insomnia,irritability,anxiety,suicidal attempt)in four studies.When comparing active TMS vs sham treatment,the risk of developing HMS was not significantly different between conditions.CONCLUSION Applying the most usual protocols and the appropriate precautionary measures,TMS seems not to be related to HMS development. | Andrea Miuli Gianna Sepede Gianfranco Stigliano Alessio Mosca Francesco Di Carlo Giacomo d’Andrea Aliseo Lalli Maria Chiara Spano Mauro Pettorruso Giovanni Martinotti Massimo Di Giannantonio | 2021 | World Journal of Psychiatry2021，11，8： | 0 |
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