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| 1 | Fetal programming and early identification of newborns at high risk of free radical-mediated diseases显示文摘Nowadays metabolic syndrome represents a real outbreak affecting society. Paradoxically, pediatricians must feel involved in fighting this condition because of the latest evidences of developmental origins of adult diseases. Fetal programming occurs when the normal fetal development is disrupted by an abnormal insult applied to a critical point in intrauterine life. Placenta assumes a pivotal role in programming the fetal experience in utero due to the adaptive changes in structure and function. Pregnancy complications such as diabetes, intrauterine growth restriction, preeclampsia, and hypoxia are associated with placental dysfunction and programming. Many experimental studies have been conducted to explain the phenotypic consequences of fetal-placental perturbations that predispose to the genesis of metabolic syndrome, obesity, diabetes, hyperinsulinemia, hypertension, and cardiovascular disease in adulthood. In recent years, elucidating the mechanisms involved in such kind of process has become the challenge of scientific research. Oxidative stress may be the general underlying mechanism that links altered placental function to fetal programming. Maternal diabetes, prenatal hypoxic/ischaemic events, inflammatory/infective insults are specific triggers for an acute increase in free radicals generation. Early identification of fetuses and newborns at high risk of oxidative damage may be crucial to decrease infant and adult morbidity. | Serafina Perrone Antonino Santacroce Anna Picardi Giuseppe Buonocore | 2016 | World Journal of Clinical Pediatrics2016，5，2： | 4 |
| 2 | Functional magnetic resonance imaging of internet addiction in young adults显示文摘AIM: To report the results of functional magnetic resonance imaging(f MRI) studies pertaining internet addiction disorder(IAD) in young adults.METHODS: We conducted a systematic review on Pub Med, focusing our attention on f MRI studies involving adult IAD patients, free from any comorbid psychiatric condition. The following search words were used, both alone and in combination: f MRI, internet addiction, internet dependence, functional neuroimaging. The search was conducted on April 20^(th), 2015 and yielded 58 records. Inclusion criteria were the following: Articles written in English, patients' age ≥ 18 years, patients affected by IAD, studies providing f MRI results during resting state or cognitive/emotional paradigms. Structural MRI studies, functional imaging techniques other than f MRI, studies involving adolescents, patients with comorbid psychiatric, neurological or medical conditions were excluded. By reading titles and abstracts, we excluded 30 records. By reading the full texts of the 28 remaining articles, we identified 18 papers meeting our inclusion criteria and therefore included in the qualitative synthesis.RESULTS: We found 18 studies fulfilling our inclusion criteria, 17 of them conducted in Asia, and including a total number of 666 tested subjects. The included studies reported data acquired during resting state or different paradigms, such as cue-reactivity, guessing or cognitive control tasks. The enrolled patients were usually males(95.4%) and very young(21-25 years). The most represented IAD subtype, reported in more than 85% of patients, was the internet gaming disorder, or videogame addiction. In the resting state studies, the more relevant abnormalities were localized in the superior temporal gyrus, limbic, medial frontal and parietal regions. When analyzing the task related fmri studies, we found that less than half of the papers reported behavioral differences between patients and normal controls, but all of them found significant differences in cortical and subcortical brain regions involved in cognitive control and reward processing: Orbitofrontal cortex, insula, anterior and posterior cingulate cortex, temporal and parietal regions, brain stem and caudate nucleus.CONCLUSION: IAD may seriously affect young adults' brain functions. It needs to be studied more in depth to provide a clear diagnosis and an adequate treatment. | Gianna Sepede Margherita Tavino Rita Santacroce Federica Fiori Rosa Maria Salerno Massimo Di Giannantonio | 2016 | World Journal of Radiology2016，8，2： | 4 |
| 3 | 4565例良性颅内脑膜瘤放射外科治疗后的长期疗效研究显示文摘背景与目的 自Leksell发明伽玛刀以来,放射外科应用于临床已有30余年,因其可避免繁杂的开颅术及感染、颅内出血等危险因素而广泛应用于颅内肿瘤。目前,颅内良性脑膜瘤放射外科治疗的长期疗效与安全性评估主要侧重于肿瘤生长及恶变的控制,有关的报道亦不少见,但还未有多中心、大样本的报道。研究纳入了多个中心的4565例良性颅内脑膜瘤经放射外科治疗后的临床资料, | Santacroce A Walier M Régis J 刘嘉 | 2012 | 中国肿瘤外科杂志2012，4，4： | 3 |
| 4 | Microbiota revolution:How gut microbes regulate our lives显示文摘The human intestine is a natural environment ecosystem of a complex of diversified and dynamic microorganisms,determined through a process of competition and natural selection during life.Those intestinal microorganisms called microbiota and are involved in a variety of mechanisms of the organism,they interact with the host and therefore are in contact with the organs of the various systems.However,they play a crucial role in maintaining host homeostasis,also influencing its behaviour.Thus,microorganisms perform a series of biological functions important for human well-being.The host provides the microorganisms with the environment and nutrients,simultaneously drawing many benefits such as their contribution to metabolic,trophic,immunological,and other functions.For these reasons it has been reported that its quantitative and qualitative composition can play a protective or harmful role on the host health.Therefore,a dysbiosis can lead to an association of unfavourable factors which lead to a dysregulation of the physiological processes of homeostasis.Thus,it has previously noted that the gut microbiota can participate in the pathogenesis of autoimmune diseases,chronic intestinal inflammation,diabetes mellitus,obesity and atherosclerosis,neurological disorders(e.g.,neurological diseases,autism,etc.)colorectal cancer,and more. | Marica Colella Ioannis Alexandros Charitos Andrea Ballini Concetta Cafiero Skender Topi Raffaele Palmirotta Luigi Santacroce | 2023 | World Journal of Gastroenterology2023，29，28： | 2 |
| 5 | Helicobacter pylori infection and gastric MALTomas: an up-to- date and therapy highlight 显示文摘 | SANTACROCE L CAGIANO R DEL PRETE R | 2008 | Clin Ther2008，159，6： | 1 |
| 6 | Uncertainty,posttraumatic stress and health behavior in young adult childhood cancer survivors显示文摘 | Santacroce SJ Lee YL | 2006 | Nurs Res2006，55，4： | 1 |
| 7 | Hypemficemia and gom tllymid endocfine disofden显示文摘 | Giordano N Santacroce C Magi G | 2001 | CHn Exp Rheumatol2001，19，6： | 1 |
| 8 | Analysis of clinically relevant single-nuleotide polymorphisms by use of microelectronic array technology显示文摘 | Ratti A Caroli F | 2002 | Clin Chem2002，48，12： | 1 |
| 9 | Afla- toxins in aquatic species: metabolism, toxicity and perspec- tives 显示文摘 | Santacroce M P Conversano M C Casalino E | 2008 | Reviews in Fish Biology and Fisheries2008，18，： | 1 |
| 10 | The spectrum of subclinical Best vitelliform macular dystrophy in subjects with mutations in BEST1 gene 显示文摘 | Querques G Zerbib J Santacroce R | 2011 | Invest Ophthalmol Vis Sci2011，52，7： | 1 |
| 11 | Exponential utility maximization under partial information显示文摘 | Mania M Santacroce M | 2010 | Finance and Stochastics2010，14，： | 1 |
| 12 | Low protein Z lev- els and risk of occurrence of deep vein thrombosis 显示文摘 | SANTACROCE R SAMO M CAPPUCCI F | 2006 | J Thromb Haemost2006，4，11： | 1 |
| 13 | Helicobacter pylori infection and gastric MALTomas:an up-to-date and therapy highlight显示文摘 | Santacroce L Cagiano R Del Prete R et a1 | 2008 | Clin Ter2008，159，6： | 1 |
| 14 | The role ofoxidative stress on necrotizing enterocolitis in very low birth weightinfants显示文摘 | Perrone S Tataranno M L Santacroce A | 2014 | Curr Pediatr Rev2014，10，3： | 1 |
| 15 | Aflatoxin M1 in dairy products: a public health program? 显示文摘 | Montagna M T Minervini F Santacroce M P | 2002 | Ann Ig2002，14，： | 1 |
| 16 | 水生物种中黄曲霉毒素的代谢及毒性研究(五)显示文摘3.7遗传毒性
国际癌症研究所(IARC)认定黄曲霉毒素是已知的最强基因毒性剂(IARC,1993)。在哺乳动物中,AFB,加合到DNA上后,可产生染色体畸变、微核、姐妹染色单体互换、程序外DNA合成及染色体链断裂(IARC,1993)。 | 王银东 黄广明 Santacroce M P Conversano M C Casalino E | 2010 | 中国畜牧杂志2010，46，16： | 1 |
| 17 | Protein Z gene polymorphisms are associated with protein Z plasma levels显示文摘 | Santacroce R Cappucci F Di pema P | 2004 | J Thromb Haemost2004，2，7： | 1 |
| 18 | Af- latoxins in aquatic species: metabolism, toxicity and per- spectives 显示文摘 | Santacroce M P Conversano M C Casalino E | 2008 | Rev Fish Biol Fisher2008，18，： | 1 |
| 19 | Does it make sense that diabetes is reciprocally associated with periodontal disease显示文摘 | Santacroce L Carlaio RG Bottalico L | 2010 | Endocr Metab Immune Disord Drug Targets2010，10，1： | 1 |
| 20 | Mutation analysis in hyperphenylalaninemia patients from South Italy显示文摘 | Roberta Trunzo Rosa Santacroce Giovanna D’Andrea Vittoria Longo Giuseppe De Girolamo Claudia Dimatteo Angelica Leccese Vincenza Lillo Francesco Papadia Maurizio Margaglione | 2013 | Clinical Biochemistry2013，，： | 1 |
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