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您的检索式：作者名="Seon In Hwang"
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| 1 | Inhibition of BET selectively eliminates undifferentiated pluripotent stem cells显示文摘Embryonic stem cells(ESCs) maintain their cellular identity through the systematic regulation of master transcription factors and chromatin remodeling complexes. Recent work has shown that the unusually large-scale enhancers—namely super-enhancers(SEs), on which BRD4, a member of the bromodomain and extraterminal domain(BET) family is highly enriched—could regulate pluripotency-related transcription factors. Moreover, inhibition of BRD4 binding on SEs has been shown to induce the differentiation of ESCs. However, the underlying mechanism of BRD4 inhibition-mediated stem cell differentiation remains elusive. Here we show that both mouse and human ESCs lose their capacity for self-renewal upon treatment with JQ1, a selective inhibitor of BET family including BRD4, with rapid suppression of pluripotency-associated genes. Notably, a high concentration of JQ1 could selectively eliminate ESCs via apoptosis, without affecting the functionality of differentiated somatic cells from ESCs, suggesting that inhibition of BET may have a beneficial effect on the development of pluripotent stem cell-based cell therapy. | Jung Hyun Im Seon In Hwang Jong-Wan Kim soon-Jung Park Kyu-ree Kang Jueng Soo You Kee Pyo Kim Sung-Hwan Moon Hyuk-Jin Cha Hyung-Min Chung Hans R. Scholer Jung Keun Hyun DongWook Han | 2018 | Science Bulletin2018，63，8： | 2 |
| 2 | Determination and validation of tetrodotoxin in human whole blood using hydrophilic interaction liquid chromatography–tandem mass spectroscopy and its application显示文摘 | Hwang Eui Cho Su Youn Ahn In Seop Son Sangwhan In Ran Seon Hong Dong Woo Kim Sang Hee Woo Dong Cheul Moon Suncheun Kim | 2011 | Forensic Science International (-)2011，，1： | 2 |
| 3 | Method validation for simultaneous determination of chromium, molybdenum and selenium in infant formulas by ICP-OES and ICP-MS显示文摘 | Naeem Khan In Seon Jeong In Min Hwang Jae Sung Kim Sung Hwa Choi Eun Yeong Nho Ji Yeon Choi Byung-Man Kwak Jang-Hyuk Ahn Taehyung Yoon Kyong Su Kim | 2013 | Food Chemistry2013，，4： | 1 |
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