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| 1 | Role of sex steroid receptors in pathobiology of hepatocellular carcinoma显示文摘The striking gender disparity observed in the incidence of hepatocellular carcinoma (HCC) suggests an important role of sex hormones in HCC pathogenesis. Though the studies began as early as in 1980s,the precise role of sex hormones and the significance of their receptors in HCC still remain poorly understood and perhaps contribute to current controversies about the potential use of hormonal therapy in HCC. A comprehensive review of the existing literature revealed several shortcomings associated with the studies on estrogen receptor (ER) and androgen receptor (AR) in normal liver and HCC. These shortcomings include the use of less sensitive receptor ligand binding assays and immunohistochemistry studies for ERα alone until 1996 when ERβ isoform was identified. The animal models of HCC utilized for studies were primarily based on chemical-induced hepatocarcinogenesis with less similarity to virus-induced HCC pathogenesis. However,recent in vitro studies in hepatoma cells provide newer insights for hormonal regulation of key cellular processes including interaction of ER and AR with viral proteins. In light of the above facts,there is an urgent need for a detailed investigation of sex hormones and their receptors in normal liver and HCC. In this review,we systematically present the information currently available on androgens,estrogens and their receptors in normal liver and HCC obtained from in vitro,in vivo experimental models and clinical studies. This information will direct future basic and clinical research to bridge the gap in knowledge to explore the therapeutic potential of hormonal therapy in HCC. | Mamta Kalra Jary Mayes Senait Assefa Anil K Kaul Rashmi Kaul | 2008 | World Journal of Gastroenterology2008，14，39： | 18 |
| 2 | TGF-β1基因多态性与肝炎后肝纤维化的相关性研究显示文摘目的:探讨TGF-β1基因多态性与肝炎后肝纤维化的关系。方法:以实时荧光PCR结合熔点曲线分析,建立可高通量检测TGF-β1编码区3个单核苷酸多态性(SNPs)位点的LightCycler方法,这3个位点分别为Leu10Pro(T>C)、Arg25Pro(G>C)、Thr263Ile(C>T),并对亚洲人群中HBV感染导致的肝纤维化患者(90例)及高加索人群中HCV感染导致的肝纤维化患者(210例)进行SNP分析,并分别与104例亚洲人群和50例高加索人群正常献血员进行比较。结果:亚洲人群中病患组与正常对照组TGF-β1编码区第25、263位氨基酸皆无基因多态性,与高加索人群的检测结果有显著差异;而亚洲人群第10位氨基酸基因多态性出现频率相对较高,病患组(T/C=0.444/0.556)较正常对照组(T/C=0.514/0.486)突变频率稍高,但无显著差异。在高加索人群HCV感染导致的肝纤维化患者中第10、25位氨基酸基因多态性出现的频率与肝纤维化发展程度(average METAVIR-Score)密切相关。结论:提示TGF-β1基因多态性与高加索人群肝炎后肝纤维化的发生具有重要相关性;与亚洲人群肝炎后肝纤维化发生的相关性有待进一步研究。 | 王皓 杨再兴 高春芳 万漠彬 王晓今 Senait Mengsteab Axel M.Gressner Ralf Weiskirchen | 2004 | 第二军医大学学报2004，25，12： | 5 |
| 3 | The effect of hyaluronic acid on biofunctionality of gelatin–collagen intestine tissue engineering scaffolds显示文摘 | Vahid Shabafrooz Masoud Mozafari Gerwald A. K?hler Senait Assefa Daryoosh Vashaee Lobat Tayebi | 2014 | J. Biomed. Mater. Res2014，，9： | 1 |
| 4 | Timing of Development of Measles-Specific Immunoglnb-ulin M and G after primary Measles Vaccination 显示文摘 | Rita F Helfand Senait Kebede Howard E Gary | 1996 | Clin Diagn Lab Immunol1996，6，2： | 1 |
| 5 | Analysis of polymorphicTGF-β1 codons 10, 25, and 263 in a German patient group with non-syndromic cleft lips, alreolus, and palate compared with healthy adults 显示文摘 | Christian S Senait M Doris S | 2004 | BMC Medical Genetics2004，5，： | 1 |
| 6 | Analysis of the transforming growth factor-β1 (TGF-β1) codon 25 gene polymorphism by LightCycler-analysis in patients with chronic hepatitis C infection显示文摘 | Carmen G. Tag Senait Mengsteab Claus Hellerbrand Frank Lammert Axel M. Gressner Ralf Weiskirchen | 2003 | Cytokine2003，，5： | 1 |
| 7 | Oro-facial tumor in ethiopian patients显示文摘 | Makonnen N Senait E Million M | 1994 | J Cranio-Maxillo Facial Surgery1994，22，： | 1 |
| 8 | Timing of Development of Measles-Specific Immunoglobulin M and G after Primary Measles Vaccination显示文摘 | Rita F Helfand Senait Kebede Howard E Gary | 1999 | Clin Diagn Lab Immunol1999，6，2： | 1 |
| 9 | Polycyclic Aromatic Hydrocarbon (PAH) Exposure and DNA Adduct Semi-Quantitation in Archived Human Tissues显示文摘 | Pratt M Margaret John Kaarthik MacLean Allan B Afework Senait Phillips David H Poirier Miriam C | 2011 | International Journal of Environmental Research and Public Health2011，，7： | 1 |
| 10 | Probiotic Interference of Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 with the Opportunistic Fungal Pathogen Candida albicans显示文摘 | Gerwald A. K?hler Senait Assefa Gregor Reid Susan Cu-Uvin | 2012 | Infectious Diseases in Obstetrics and Gynecology2012，，： | 1 |
| 11 | Assessment of Deposit mobilization in Ethiopian Commercial Banks显示文摘Deposit mobilization is an integral part of banking activity.Mobilization of savings through intensive deposit collection has beenregarded as the major task of banking in Ethiopia today.Acceptance of deposits is the primary function of commercial banks.As such,depositmobilization is one of the basic innovations in current Ethiopian banking activity. | Senait Zeray Demewez | 2013 | 科技致富向导2013，，2： | 0 |
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