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| 1 | Totally intracorporeal robot-assisted urinary diversion for bladder cancer(part 2).Review and detailed characterization of the existing intracorporeal orthotopic ileal neobladder显示文摘Objective:To review the most used intracorporeal orthotopic ileal neobladder(ICONB)after radical cystectomy for bladder cancer and create a unified compendium of the different alternatives,including new consistent images.Methods:We performed a non-systematic review of the literature with the keywords“bladder cancer”,“urinary diversion”,“radical cystectomy”,and“neobladder”.Results:Forty studies were included in the analysis.The most frequent type of ICONB was the modified Studer“U”neobladder(70%)followed by the Hautmann“W”modified neobladder(7.5%),the“Y”neobladder(5%),and the Padua neobladder(5%).The operative time to perform a urinary diversion ranged from 124 to 553 min.The total estimated blood loss ranged from 200 to 900 mL.The rate of positive surgical margins ranged from 0%to 8.1%.Early minor and major complication rates ranged from 0%to 100%and from 0%to 33%,respectively.Late minor and major complication rates ranged from 0%to 70%and from 0%to 25%,respectively.Conclusion:The most frequent types of ICONB are Studer“U”neobladder,Hautmann“W”neobladder,“Y”neobladder,and the Padua neobladder.Randomized studies comparing the performance of the different types of ICONB,the performance in an intra or extracorporeal manner,or the performance of an ICONB versus ICIC are lacking in the literature.To this day,there are not sufficient quality data to determine the supremacy of one technique.This manuscript represents a compendium of the most used ICONB with detailed descriptions of the technical aspects,operative and perioperative outcomes,and new consistent images of each technique. | Hugo Otaola-Arca Kulthe Ramesh Seetharam Bhat Vipul R.Patel Marcio Covas Moschovas Marcelo Orvieto | 2021 | Asian Journal of Urology2021，8，1： | 5 |
| 2 | Nerve-sparing robot-assisted radical prostatectomy:Current perspectives显示文摘Robotic-assisted radical prostatectomy(RARP)is the current standard of care with long term cure in organ-confined disease.The introduction of nerve-sparing(NS)to standard RARP has shown positive results in terms of functional outcomes in addition to the oncological outcomes.This article reviews the current perspectives of NS-RARP in terms of applied anatomy of the prostatic fascial planes,the neurovascular bundle(NVB),various NS techniques and postoperative functional outcomes.A non-systematic review was done using PubMed,Embase and Medline databases to retrieve and analyse articles in English,with following keywords“prostate cancer”,“robotic radical prostatectomy”,“nerve-sparing”.The Delphi method was used with an expert panel of robotic surgeons in urology to analyse the potency outcomes of various published comparative and non-comparative studies.The literature has shown that NS-RARP involves various techniques and approaches while there is a lack of randomized studies to suggest the superiority of one over the other.Variables such as preoperative risk assessments,baseline potency,surgical anatomy of individual patients and surgeons’expertise play a major role in the outcomes.A tailored approach for each patient is required for applying the NS approach during RARP. | Anup Kumar Vipul RPatel Sridhar Panaiyadiyan Kulthe Ramesh Seetharam Bhat Marcio Covas Moschovas Brusabhanu Nayak | 2021 | Asian Journal of Urology2021，8，1： | 4 |
| 3 | Single-port technique evolution and current practice in urologic procedures显示文摘Different groups described the single-port surgery since its first report in laparoscopic procedures.However,the acceptance of this technique among urologists,even after the robotic approach,was reduced in the past years.Therefore,to overcome the challenges related to the single-port surgery,a new robotic platform named da Vinci SP was created with exclusive single port technology.We performed a non-systematic literature review regarding the single port technique in urologic surgeries since the first laparoscopic report until the da Vinci SP robotic platform.Three different periods were described(laparoscopy,robotic,and da Vinci SP),and we focused in our experience with this new single port robot.We selected different articles and summarized the information regarding the use of single-site surgery in laparoscopic procedures and the challenges of this approach.We also reported the experience of different groups using the single port robotic technique and some recent reports of the da Vinci SP approach.In our experience with this new console,we described some critical points related to our radical prostatectomy technique and the lessons learned during the introduction of this novel platform.Previous single-site procedures described some common challenges that limited the technique expansion.However,our experience with the da Vinci SP described feasible and safe procedures with acceptable intraoperative outcomes.The introduction of this platform is recent in the market,and the literature still lacks a high level of evidence describing the long-term outcomes of this new technology. | Marcio Covas Moschovas Kulthe Ramesh Seetharam Bhat Fikret Fatih Onol Travis Rogers Gabriel Ogaya-Pinies Shannon Roof Vipul R.Patel | 2021 | Asian Journal of Urology2021，8，1： | 3 |
| 4 | Magnetic resonance imaging-guided prostate biopsydA review of literature显示文摘Objective:Multiparametric magnetic resonance imaging(MP-MRI)helps to identify lesion of prostate with reasonable accuracy.We aim to describe the various uses of MP-MRI for prostate biopsy comparing different techniques of MP-MRI guided biopsy.Materials and methods:A literature search was performed for“multiparametric MRI”,“MRI fusion biopsy”,“MRI guided biopsy”,“prostate biopsy”,“MRI cognitive biopsy”,“MRI fusion biopsy systems”,“prostate biopsy”and“cost analysis”.The search operation was performed using the operator“OR”and“AND”with the above key words.All relevant systematic reviews,original articles,case series,and case reports were selected for this review.Results:The sensitivity of MRI targeted biopsy(MRI-TB)is between 91%e93%,and the specificity is between 36%e41%in various studies.It also has a high negative predictive value(NPV)of 89%e92%and a positive predictive value(PPV)of 51%e52%.The yield of MRI fusion biopsy(MRI-FB)is similar,if not superior to MR cognitive biopsy.In-bore MRI-TB had better detection rates compared to MR cognitive biopsy,but were similar to MR fusion biopsy.Conclusions:The use of MRI guidance in prostate biopsy is inevitable,subject to availability,cost,and experience.Any one of the three modalities(i.e.MRI cognitive,MRI fusion and MRI in-bore approach)can be used.MRI-FB has a fine balance with regards to accuracy,practicality and affordability. | Kulthe Ramesh Seetharam Bhat Srinivas Samavedi Marcio Covas Moschovas Fikret Fatih Onol Shannon Roof Travis Rogers Vipul R.Patel Ananthakrishnan Sivaraman | 2021 | Asian Journal of Urology2021，8，1： | 3 |
| 5 | Effect of copper nanoparticles exposure in the physiology of the common carp(Cyprinus carpio):Biochemical,histological and proteomic approaches显示文摘Copper nanoparticles(Cu-NPs)are serious water pollutants but their impact in teleosts performance remains poorly understood.In the present study,we have exposed juvenile carps(Cyprinus carpio),a freshwater teleost edible in India to two different doses(20 and 100 mg/L)of Cu-NPs for seven days.The doses selected were eco-relevant considering the contamination levels of certain water resources.The results indicated that the activity oxidative stress enzymes catalase,superoxide dismutase,and glutathione-S-transferase were significantly increased in the kidney,liver and gills of the treated groups when compared to control.Histological analysis revealed that after exposure,disruption of the secondary lamellae of gills,liver damage with pyknotic nuclei and structural disarray of the kidney occurred.Proteomic analysis of the liver showed down-regulation of several proteins including the ferritin heavy chain,rho guanine nucleotide exchange factor 17-like,cytoglobin-1 and up-regulation of diphosphomevalonate decarboxylase and selenide&water dikinase-1.Taken together,the results of suggest that short-term exposure of juvenile carp to Cu-NPs causes oxidative stress and impart serious deleterious effects in the tissues which may affect fish growth and development. | Yugantak Raj Gupta Durai Sellegounder Monica Kannan Seetharam Deepa Balasubramanian Senthilkumaran Yaraguntappa Basavaraju | 2016 | Aquaculture and Fisheries2016，1，1： | 2 |
| 6 | Robotic surgery techniques to approach benign prostatic hyperplasia disease:A comprehensive literature review and the state of art显示文摘Objective:The robotic-assisted approach to simple prostatectomy(RASP)was conceived,essentially reproducing the fundaments of open simple prostatectomy.Since the first report,RASP underwent several technical modifications.The study aims to identify and describe the current robotic surgery techniques to approach benign prostatic hyperplasia(BPH).Methods:The paper performed a non-systematic literature review accessing PubMed and Embase databases for all full-text articles published from 2008 to May 2020,assessing robot-assisted surgical techniques for BPH treatment using the terms“robot-assisted simple prostatectomy”OR“robotic simple prostatectomy”OR“RASP”AND“surgical technique”.Results:After careful review of 180 studies in PubMed and 198 in Embase,16 papers reporting different RASP techniques.After the first procedure described by Sotelo et al.[9],several authors contributed to the development of the RASP technique.John et al.[24]proposed the extraperitoneal access,and Yuh et al.[23]first reported the adenoma transcapsular dissection.Some modifications were proposed by Coelho et al.[31]on trigonization,posterior reconstruction,and urethro-vesical anastomosis.Other groups focused on urethral-preserving procedures.Moschovas et al.[28]and Clavijo et al.[32]recently described an intrafascial RASP with the removal of the entire prostatic tissue.Finally,Kaouk et al.[29]reported the feasibility and safety of the da Vinci Single Port approach.Conclusion:In the last eighteen years,the robotic-assisted approach to BPH disease has been evolved,and different techniques have been described.This review details all the technical developments on RASP that distinctive groups have proposed since the multiport robotic platforms until the new da Vinci Single Port. | Marcio Covas Moschovas Frederico Timo´teo Leonardo Lins Ose´as de Castro Neves Kulthe Ramesh Seetharam Bhat Vipul R.Patel | 2021 | Asian Journal of Urology2021，8，1： | 2 |
| 7 | Increased cytotoxic activity of PE and two chimeric toxins ending in KDEL显示文摘 | Seetharam S Chaudhary VK FitzGerald DJ | 1991 | Biol Chem1991，266，17： | 1 |
| 8 | Randomized, Clinical Trial of Ligasure? vs. Conventional Diathermy in Hemorrhoidectomy显示文摘 | Ernest J. Franklin M.D. Seema Seetharam M.R.C.S. Jennifer Lowney M.D. Paul G. Horgan Ph.D | 2003 | Diseases of the Colon & Rectum2003，，10： | 1 |
| 9 | Comparison of intra-peritoneal bupivacaine and intravenous paracetamol for postoperative pain relief after laparoscopic cholecystectomy显示文摘 | Upadya M Pushpavathi SH Seetharam KR | 2015 | Anesth Essays Res2015，9，1： | 1 |
| 10 | Association of polymorphic hght eruption and autoimmune thyroiditis显示文摘 | Seetharam KA Sridevi K | 2010 | Indian J Dermatol Venereol Leprol2010，76，6： | 1 |
| 11 | The scavenger receptor class B type I adaptor protein PDZK1 maintains endothelial monolayer integrity 显示文摘 | Zhu W Saddar S Seetharam D | 2008 | Circ Res2008，102，4： | 1 |
| 12 | A new communication system between hepatocytes and sinusoidal endothelial cells in liver through vascular endothelial growth factor and Fittyrosine kinase receptor family ( Fit- 1 and KDR/Flk- 1 ) 显示文摘 | Yamane A Seetharam L Yamaguchi S etal | 1994 | Oncogene1994，9，： | 1 |
| 13 | Antitumor interaction of short-course endostatin and ionizing radition显示文摘 | Hanna NN Seetharam S Mauceri H J | 2000 | Cancer2000，6，5： | 1 |
| 14 | Increased cytotoxic activity of Pseudomonas exotoxin and two chimeric toxins ending in KDEL显示文摘 | Seetharam S Chandhary VK FitzGerald D | 1991 | J Biol Chem1991，266，17： | 1 |
| 15 | Comparison of intra- per- itoneal bupivaeaine and intravenous paraeetamol for postoperative pain relief after laparoscopic eholeeysteetomy显示文摘 | Upadya M Pushpavathi SH Seetharam KR | 2015 | Anesth Essays Res2015，9，1： | 1 |
| 16 | Targeting IL-13Ralpha2- positive cancer with a novel recombinant immunotoxin composed of a single-chain antibody and mutated Pseudomonas exotoxin 显示文摘 | Kioi M Seetharam S Puri RK | 2008 | Mol Cancer Ther2008，7，6： | 1 |
| 17 | The scavenger receptor class B type Ⅰ adaptor protein PDZK1 maintains endothelial monolayer integrity显示文摘 | Zhu W Saddar S Seetharam D | | 0，，： | 1 |
| 18 | Measuring welfare gains from relaxation of land-use restrictions: The case of India’s building-height limits显示文摘 | Jan K. Brueckner Kala Seetharam Sridhar | 2012 | Regional Science and Urban Economics2012，，6： | 1 |
| 19 | Biotransformation of cholester- ol to diosgenin by freely suspended and immobilised cells of Di- oscorea bulbifera L 显示文摘 | Jyothishwaran G Seetharam Y N | 2008 | J Asian Nat Prod Res2008，0，12： | 1 |
| 20 | A unique signal transduction from FLT tyrosine,a receptor for vascular endothelial growth factor VEGF显示文摘 | Seetharam L Gotoh N Maru Y | 1995 | Oncogene1995，10，： | 1 |
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