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| 1 | Relationship between Crohn’s disease, infection with Mycobacterium avium subspecies paratuberculosis and SLC11A1 gene polymorphisms in Sardinian patients显示文摘AIM: To study the association between Crohn’s disease (CD), Mycobacterium avium subspecies paratubercu- losis (MAP), and genetic factors by examining the role of natural resistance-associated macrophage protein 1 (NRAMP1) gene polymorphisms (now SLC11A1) in Sar dinian patients with CD and controls. METHODS: Thirty-seven CD patients and 34 controls with no inflammatory bowel disease (IBD) were recruited at the University of Sassari after giving written con sent. Six SCL11A1 polymorphisms previously reported to be the most significantly associated with IBD were searched. M. paratuberculosis was identified by IS900 PCR and sequencing. Logistic regression was used to cal culate odds ratios (OR) for the associations among CD presence of MAP, and 6 loci described above. RESULTS: For the first time, a strong association was observed between polymorphisms at NRAMP1 locus 823C/T and CD. While CD was strongly associated withboth NRAMP1 and MAP, NRAMP1 polymorphisms and MAP themselves were not correlated. CONCLUSION: Combined with previous work on the NOD2/CARD15 gene, it is clear that the interplay of ge- netic, infectious, and immunologic factors in the etiology of CD is complex. | Leonardo A Sechi Maria Gazouli Lee E Sieswerda Paola Molicotti Niyaz Ahmed John Ikonomopoulos Antonio M Scanu Daniela Paccagnini Stefania Zanetti | 2006 | World Journal of Gastroenterology2006，12，44： | 3 |
| 2 | In situ characterization of renal insulin receptors in the rat显示文摘 | Sechi LA De Carli S Bartoli E | 1994 | J Recept Res1994，14，： | 1 |
| 3 | Executive function impairment in early-treated PKU subjects with normal mental development显示文摘 | Leuzzi V Pansini M Sechi E | 2004 | J Inherit Metab Dis2004，27，2： | 1 |
| 4 | Mycobacterium avium subspecies paratuberculosis infects and multiplies in enteric glial cells显示文摘AIM: To establish the role of enteric glial cells during infection with Mycobacterium avium subspecies paratuberculosis (MAP) in Crohn's disease. METHODS: In order to establish the role of enteric glial cells during infection with M. avium subspecies paratuberculosis (MAP) in Crohn's disease, Map adhesion experiments on enteric glial cells were performed as well as expression analysis of Map sigma factors during infection. RESULTS: In this study, for the first time, we found a high affinity of MAP to enteric glial cells and we analyzed the expression of MAP sigma factors under different conditions of growth. CONCLUSION: The fact that Map showed a high affinity to the glial cells raises concerns about the complicated etiology of the Crohn's disease. Elucidation of the mechanisms whereby inflammation alters enteric neural control of gut functions may lead to novel treatments for Crohn's disease. | Leonardo A Sechi Anne Ruehl Niyaz Ahmed Donatella Usai Daniela Paccagnini Giovanna E Felis Stefania Zanetti | 2007 | World Journal of Gastroenterology2007，13，43： | 1 |
| 5 | Executive function impairment in early-treated PKU subjects with normal mental development显示文摘 | Leuzzi V Pansini M Sechi E Chiarotti F Carducci C Levi G | 2004 | J Inherit Metab Dis2004，27，2： | 1 |
| 6 | In site characterization of renal insulin receptors in the rat显示文摘 | Sechi LA De Carli S Bartoli E | 1994 | J Recept Res1994，14，68： | 1 |
| 7 | Propane oxydehydrogenation over alumina-supported vanadia doped with manga- nese and potassium显示文摘 | ERMINI V FINOCCHIO E SECHI S | 2000 | Appl Catal A2000，198，： | 1 |
| 8 | Executive function impairment in early-treated PKU subjects with normal mental development显示文摘 | Leuzzi V Pansini M Sechi E | 2004 | J Inherit Metab Dis2004，27，： | 1 |
| 9 | Mycobacterium avium subsp. paratuberculosis and multiple sclerosis in Sardinian patients: epidemiology and clinical features显示文摘 | J Frau D Cossu G Coghe L Lorefice G Fenu M Melis D Paccagnini C Sardu MR Murru S Tranquilli MG Marrosu LA Sechi E Cocco | 2013 | Multiple Sclerosis Journal2013，，11： | 1 |
| 10 | Executive function impairment in ear/y-treated PKU subjects with normal mental development显示文摘 | Leuzzi V Pansini M Sechi E | 2004 | Inherit Metab Dis2004，27，： | 1 |
| 11 | Execuivc function impair- ment in early-treated PKU subjects with normal mental dcvelopcent 显示文摘 | Leuzzi V Pansisi M Sechi E | 2004 | J Inherit Metab Dis2004，27，2： | 1 |
| 12 | Expression of AT2 receptors in the developing rat fetus显示文摘 | Grady E F Sechi L A Griffin C A | 1991 | J Clin Invest1991，88，： | 1 |
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