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| 1 | Early renal failure as a cardiovascular disease:Focus on lipoprotein(a) and prothrombotic state显示文摘Patients with renal failure are at increased risk of cardiovascular events even at the earliest stages of disease.In addition to many classic cardiovascular risk factors,many conditions that are commonly identified as emerging risk factors might contribute to occurrence of cardiovascular disease.Changes in circulating levels of many of these emerging risk factors have been demonstrated in patients with early stages of renal failure caused by different types of renal disease and have been associated with detection of cardiovascular complications.However,for most of these factors evidence of benefits of correction on cardiovascular outcome is missing.In this article,we comment on the role of lipoprotein(a) and prothrombotic factors as potential contributors to cardiovascular events in patients with early renal failure. | Cristiana Catena Gian Luca Colussi Francesca Nait Francesca Pezzutto Flavia Martinis Leonardo A Sechi | 2015 | World Journal of Nephrology2015，4，3： | 4 |
| 2 | Sustained virologic response to direct-acting antiviral agents predicts better outcomes in hepatitis C virus-infected patients: A retrospective study显示文摘BACKGROUND Direct-acting antiviral agents(DAAs)are extremely effective in eradicating hepatitis C virus(HCV)in chronically infected patients.However,the protective role of the sustained virologic response(SVR)achieved by second-and thirdgeneration DAAs against the onset of hepatocellular carcinoma(HCC)and mortality is less well established.AIM To examine the occurrence of HCC or death from any cause in a retrospectiveprospective study of patients treated with DAAs.METHODS Patients were enrolled from a tertiary academic hospital center for liver disease management that collects subject data mainly from northeastern Italy.The study was conducted in 380 patients(age:60±13 years,224 males,32%with cirrhosis)treated with DAAs with or without SVR(95/5%),with a median follow up of 58 wk(interquartile range:38-117).The baseline anthropometric features,HCV viral load,severity of liver disease,presence of extra-hepatic complications,coinfection with HIV and/or HBV,alcohol consumption,previous interferon use,alphafetoprotein levels,and renal function were considered to be confounders.RESULTS The incidence rate of HCC in patients with and without SVR was 1.3 and 59 per 100 person-years,respectively(incidence rate ratio:44,95%CI:15-136,P<0.001).Considering the combined endpoint of HCC or death from any cause,the hazard ratio(HR)for the SVR patients was 0.070(95%CI:0.025-0.194,P<0.001).Other independent predictors of HCC or death were low HCV viremia(HR:0.808,P=0.030),low platelet count(HR:0.910,P=0.041),and presence of mixed cryoglobulinemia(HR:3.460,P=0.044).Considering SVR in a multi-state model,the independent predictors of SVR achievement were absence of cirrhosis(HR:0.521,P<0.001)and high platelet count(HR:1.019,P=0.026).Mixed cryoglobulinemia predicted the combined endpoint in patients with and without SVR(HR:5.982,P=0.028 and HR:5.633,P=0.047,respectively).CONCLUSION DAA treatment is effective in inducing SVR and protecting against HCC or death.A residual risk of HCC persists in patients with advanced liver disease or with complications,such as mixed cryoglobulinemia or renal failure. | Gian Luca Colussi Debora Donnini Rosario Francesco Brizzi Silvia Maier Luca Valenti Cristiana Catena Alessandro Cavarape Leonardo Alberto Sechi Giorgio Soardo | 2019 | World Journal of Gastroenterology2019，25，40： | 4 |
| 3 | Relationship between Crohn’s disease, infection with Mycobacterium avium subspecies paratuberculosis and SLC11A1 gene polymorphisms in Sardinian patients显示文摘AIM: To study the association between Crohn’s disease (CD), Mycobacterium avium subspecies paratubercu- losis (MAP), and genetic factors by examining the role of natural resistance-associated macrophage protein 1 (NRAMP1) gene polymorphisms (now SLC11A1) in Sar dinian patients with CD and controls. METHODS: Thirty-seven CD patients and 34 controls with no inflammatory bowel disease (IBD) were recruited at the University of Sassari after giving written con sent. Six SCL11A1 polymorphisms previously reported to be the most significantly associated with IBD were searched. M. paratuberculosis was identified by IS900 PCR and sequencing. Logistic regression was used to cal culate odds ratios (OR) for the associations among CD presence of MAP, and 6 loci described above. RESULTS: For the first time, a strong association was observed between polymorphisms at NRAMP1 locus 823C/T and CD. While CD was strongly associated withboth NRAMP1 and MAP, NRAMP1 polymorphisms and MAP themselves were not correlated. CONCLUSION: Combined with previous work on the NOD2/CARD15 gene, it is clear that the interplay of ge- netic, infectious, and immunologic factors in the etiology of CD is complex. | Leonardo A Sechi Maria Gazouli Lee E Sieswerda Paola Molicotti Niyaz Ahmed John Ikonomopoulos Antonio M Scanu Daniela Paccagnini Stefania Zanetti | 2006 | World Journal of Gastroenterology2006，12，44： | 3 |
| 4 | 高血压患者同型半胱氨酸水平升高与代谢综合征和心血管事件相关显示文摘高同型半胱氨酸(homocysteine,Hcy)血症和代谢综合征(metabolic syndrome,MS)是明确的心血管危险因素,常与高血压相关。然而血浆Hcy与MS、胰岛素抵抗相关性存在争议,且在高血压患者中的研究较少。该研究探讨高血压患者Hcy与MS和心脑血管事件的相关性。 | Catena C Colussi G Nait F Capobianco F Sechi LA 陈云 叶鹏 | 2016 | 中华高血压杂志2016，24，1： | 2 |
| 5 | Primary aldosteronism:cardiovascular,renal and metabolic implications显示文摘 | Rossi GP Sechi LA Giacchetti G | 2008 | Trends Endocrinol Metab2008，19，3： | 1 |
| 6 | The renin-angio- tensin-aldosterone system, glucose metabolism and diabetes 显示文摘 | GILBERTA G SECHI LA SILVIA R | 2005 | Trends Endocrin Met2005，16，3： | 1 |
| 7 | Wernicke's encephalopathy: new clinical settings and recent advances in diagnosis and management显示文摘 | Sechi G Serra A | 2007 | Lancet Neurol2007，6，： | 1 |
| 8 | Nanoparticle therapeutics for prostate cancer treatment显示文摘 | Sanna V Sechi M | 2012 | Nanomedicine2012，1，： | 1 |
| 9 | Wernicke's encephalopathy in a woman on slimming diet显示文摘 | Sechi GP Serra A Pirastru MI | 2002 | Neurology2002，58，11： | 1 |
| 10 | Relationship of lipoprotein(a)to variables of coagulation in hypertensive subjects显示文摘 | Sechi LA De Marchi S | 2001 | Invest Med2001，49，1： | 1 |
| 11 | Rela- tionship of fibrinogen levels and hemostatie abnormal- ities with organ damage in hypertension显示文摘 | SECHI L A ZINGARO L CATENA C | 2000 | Hyper- tension2000，36，： | 1 |
| 12 | The rennin-angiotensin-aldosterone system,glucose metabolism and diabetes显示文摘 | Giacchetti G Sechi LA Rilli S | 2005 | Trends Endocrinol Metab2005，16，： | 1 |
| 13 | Relationship of Lp(a) to variables of coagulation in hypertensive subjects显示文摘 | Sechi LA DeMarchi S | 2001 | Jinvest Med2001，49，1： | 1 |
| 14 | A muhiprotein nucle- ar complex connects Fanconi anemia and Bloom syndrome显示文摘 | Meetei AR Sechi S Wallisch M | 2003 | Mol Cell Biol2003，23，10： | 1 |
| 15 | Neural nets for modeling rainfallrunoff transformation显示文摘 | Lorrai M Sechi G | 1995 | Water Resources Management1995，，9： | 1 |
| 16 | PER 1 type beta lac tamase production in Acinetobacter baumannii is related to cell adhesion显示文摘 | Sechi LA Karadenizli A Deriu A | 2004 | Med Sci Monit2004，10，6： | 1 |
| 17 | Clinical diagnostic utility of IP-10 and LAM antigen levels for the diagnosis of tuberculous pleural effusions in a high burden setting 显示文摘 | Dheda K Van-Zyl Smit RN Sechi LA | 2009 | PLoS One2009，4，3： | 1 |
| 18 | Fatal hyperpyrexia after withdrawal of levodopa显示文摘 | Sechi GP Tanda F Mutani R | 1984 | Neurology1984，34，2： | 1 |
| 19 | The multiple cellular functions of the oncoprotein Golgi phosphoprotein 3 显示文摘 | Sechi S Frappaolo A Belloni G | 2015 | Oncotar- get2015，6，6： | 1 |
| 20 | Tissue - spcific regulation of insulin receptor mRNA levels in rats with STZ- induced diabetes mellitus 显示文摘 | Sechi LA Griffin CA Grady EF | 1992 | Diabetes1992，41，： | 1 |
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