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| 1 | 3D additive manufactured composite scaffolds with antibiotic-loaded lamellar fillers for bone infection prevention and tissue regeneration显示文摘Bone infections following open bone fracture or implant surgery remain a challenge in the orthopedics field.In order to avoid high doses of systemic drug administration,optimized local antibiotic release from scaffolds is required.3D additive manufactured(AM)scaffolds made with biodegradable polymers are ideal to support bone healing in non-union scenarios and can be given antimicrobial properties by the incorporation of antibiotics.In this study,ciprofloxacin and gentamicin intercalated in the interlamellar spaces of magnesium aluminum layered double hydroxides(MgAl)andα-zirconium phosphates(ZrP),respectively,are dispersed within a thermoplastic polymer by melt compounding and subsequently processed via high temperature melt extrusion AM(~190◦C)into 3D scaffolds.The inorganic fillers enable a sustained antibiotics release through the polymer matrix,controlled by antibiotics counterions exchange or pH conditions.Importantly,both antibiotics retain their functionality after the manufacturing process at high temperatures,as verified by their activity against both Gram+and Gram-bacterial strains.Moreover,scaffolds loaded with filler-antibiotic do not impair human mesenchymal stromal cells osteogenic differentiation,allowing matrix mineralization and the expression of relevant osteogenic markers.Overall,these results suggest the possibility of fabricating dual functionality 3D scaffolds via high temperature melt extrusion for bone regeneration and infection prevention. | María C´amara-Torres Stacy Duarte Ravi Sinha Ainhoa Egizabal Noelia´Alvarez Maria Bastianini Michele Sisani Paolo Scopece Marco Scatto Alessandro Bonetto Antonio Marcomini Alberto Sanchez Alessandro Patelli Carlos Mota Lorenzo Moroni | 2021 | Bioactive Materials2021，6，4： | 2 |
| 2 | Shear stress-mediated chromatin remodeling provides molecular basis for flow-dependent regulation of gene expression显示文摘 | Illi B Nanni A Scopece A | | 0，，02： | 1 |
| 3 | Phase Ⅱ trial of carboplatin and etoposide for patients with recurrent high-grade glioma显示文摘 | Franceschi E Cavallo G Scopece L | | 0，，： | 1 |
| 4 | Epigenetic histone modification and cardiovascular lineage programming in mouse embryonic stem cells exposed to laminar shear stress显示文摘 | Illi B Scopece A Nanni S Farsetti A Morgante L Biglioli P | 2005 | Circ Res2005，96，： | 1 |
| 5 | Epigenetic histone modification and cardiovascular lineage programming in mouse embryonic stem cells exposed to laminar shear stress显示文摘 | ILLI B SCOPECE A NANNI S | 2005 | Circulation Research2005，96，5： | 1 |
| 6 | Genic rather than genome-wide differences between sexuallydeceptive Ophrys orchids with different pollinators 显示文摘 | SEDEEK K E M SCOPECE G STAEDLER Y M | 2014 | Mol Ecol2014，23，24： | 1 |
| 7 | Patterns of reproductive isolation in Mediterranean deceptive orchids显示文摘 | Scopece G Musacchio A Widmer A | 2007 | Evolution2007，61，11： | 1 |
| 8 | Evolution of postzogytic reproductive isolation in a guide of deceptive orchids显示文摘 | Scopece G Widmer A Cozzolino S | 2008 | The American Naturalist2008，171，3： | 1 |
| 9 | Floral isolation is the main reproductive barrier among closelyrelated sexually deceptive orchids 显示文摘 | XU Shuqing SCHLUTER P M SCOPECE G | 2011 | Evolution2011，65，9： | 1 |
| 10 | Specificity in pollination and consequences for postmating reproductive isolation in deceptiveMediterranean orchids 显示文摘 | COZZOLINO S SCOPECE G | 2008 | Philos Trans R Soc B Biol Sci/2008，363，1506： | 1 |
| 11 | Components of reproductive isolation between Orchis mascula and Orchispauciflora 显示文摘 | SCOPECE G CROCE A LEXER C | 2013 | Evolution2013，67，7： | 1 |
| 12 | Evolution of postzygotic reproductive isolation in a guild of deceptive orchids显示文摘 | SCOPECE G WIDMER A COZZOLINO S | 2008 | Am Nat2008，171，3： | 1 |
| 13 | Epigenetic histone modification and cardiovascular lineage programming in mouse embryonic stem cells exposed to laminar shear stress显示文摘 | Scopece A Nanni S | 2005 | Circ Res2005，96，5： | 1 |
| 14 | Phase Ⅱ Trial of Carboplatin and Etoposide for Patients with Recurrent Highgrade Glioma显示文摘 | Francesehi E Cavallo G Scopece L | 2004 | Br J Cancer2004，91，6： | 1 |
| 15 | Bismuth Modified Gold Nanoelectrode Ensemble for Strip- ping Voltammetric Determination of Lead显示文摘 | Mardegan A Dal Borgo S Scopece P | 2012 | Elec- trochemistry Communications2012，24，： | 1 |
| 16 | Seasonal cycling of mercury and monomethyl mercury in the VeniceLagoon (Italy) 显示文摘 | Bloom N S Moretto L M Scopece P et ai | 2004 | Ma- rine Chemistry2004，91，2： | 1 |
| 17 | Conical nanopore membranes: solvent shaping of nanopores显示文摘 | Paolo Scopece Lane A Baker Paolo Ugo | 2006 | Institute of Physics Publishing2006，，17： | 1 |
| 18 | Seasonal cycling of mercury and monomethyl mercury in the Venice Lagoon (Italy)显示文摘 | Bloom N S Moretto L M Scopece P | 2004 | Marine Chemistry2004，91，1： | 1 |
| 19 | 论花距对花序松散的倒距兰(Anacamptis Iaxiflora)雌花繁殖成功率的影响显示文摘对多花物种而言,花序结构是塑造植物吸引力的首要因素。本研究旨在揭示花序性状对植物雌花繁殖成功率的影响,以及倒距兰(Anacamptis Iaxiflora,—种采用欺骗性授粉策略的陆生物种)花序上的授粉规律。我们还探究了花序性状与雌花繁殖成功率之间的关系是否会因为周围植被的高度和/或种群密度的影响而改变。我们在一个天然的倒距兰种群中划定了实验区块,对每个区块内的植株个体进行计数,并将各区块按低密度和高密度进行分类;随后,在部分区块内,我们人工清除了植株周围的杂草,从而产生了同等数量的高草丛区块和低草丛区块。我们统计了这些区块中的花序性状和雌花繁殖成功率(即果实数量及其在花序上的位置),使用广义线性混合模型(GLMMs)对统计数据进行了分析,并计算出了选择梯度。我们发现所研究的所有花序性状均对雌花繁殖成功率造成了影响。特别是GLMMs的结果表明,“平均花距”是对繁殖成功规律的最佳预测因子。我们所研究的花序性状受到显著的正向选择作用,但是这些选择趋势与周围植被的高度和种群密度都紧密相关,表明当地环境背景对选择规律的形成有显著影响。雌花繁殖成功率与花朵在花序上的位置无关,这说明传粉者在花序上随机选择花朵,未见其对花序特定部位的偏好。本项研究突显出花序性状对于多花、具有欺骗性的兰花雌花繁殖成功的重要性,并证实了环境背景在调节传粉者介导的选择规律中的主导作用。 | Giovanni Scopece Nicola Criscuolo Salvatore Cozzolino | 2021 | Journal of Plant Ecology2021，14，3： | 0 |
| 20 | Different filtering strategies of genotyping-by-sequencing data provide complementary resolutions of species boundaries and relationships in a clade of sexually deceptive orchids显示文摘Ongoing hybridization and retained ancestral polymorphism in rapidly radiating lineages could mask recent cladogenetic events.This presents a challenge for the application of molecular phylogenetic methods to resolve differences between closely related taxa.We reanalyzed published genotyping‐by‐sequencing(GBS)data to infer the phylogeny of four species within the Ophrys sphegodes complex,a recently radiated clade of orchids.We used different data filtering approaches to detect different signals contained in the dataset generated by GBS and estimated their effects on maximum likelihood trees,global FST and bootstrap support values.We obtained a maximum likelihood tree with high bootstrap support,separating the species by using a large dataset based on loci shared by at least 30%of accessions.Bootstrap and FST values progressively decreased when filtering for loci shared by a higher number of accessions.However,when filtering more stringently to retain homozygous and organellar loci,we identified two main clades.These clades group individuals independently from their a priori species assignment,but were associated with two organellar haplotype clusters.We infer that a less stringent filtering preferentially selects for rapidly evolving lineage‐specific loci,which might better delimit lineages.In contrast,when using homozygous/organellar DNA loci the signature of a putative hybridization event in the lineage prevails over the most recent phylogenetic signal.These results show that using differing filtering strategies on GBS data could dissect the organellar and nuclear DNA phylogenetic signal and yield novel insights into relationships between closely related species. | Salvatore Cozzolino Giovanni Scopece Luca Roma Philipp M.Schluter | 2020 | Journal of Systematics and Evolution2020，58，2： | 0 |
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