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| 1 | 3D additive manufactured composite scaffolds with antibiotic-loaded lamellar fillers for bone infection prevention and tissue regeneration显示文摘Bone infections following open bone fracture or implant surgery remain a challenge in the orthopedics field.In order to avoid high doses of systemic drug administration,optimized local antibiotic release from scaffolds is required.3D additive manufactured(AM)scaffolds made with biodegradable polymers are ideal to support bone healing in non-union scenarios and can be given antimicrobial properties by the incorporation of antibiotics.In this study,ciprofloxacin and gentamicin intercalated in the interlamellar spaces of magnesium aluminum layered double hydroxides(MgAl)andα-zirconium phosphates(ZrP),respectively,are dispersed within a thermoplastic polymer by melt compounding and subsequently processed via high temperature melt extrusion AM(~190◦C)into 3D scaffolds.The inorganic fillers enable a sustained antibiotics release through the polymer matrix,controlled by antibiotics counterions exchange or pH conditions.Importantly,both antibiotics retain their functionality after the manufacturing process at high temperatures,as verified by their activity against both Gram+and Gram-bacterial strains.Moreover,scaffolds loaded with filler-antibiotic do not impair human mesenchymal stromal cells osteogenic differentiation,allowing matrix mineralization and the expression of relevant osteogenic markers.Overall,these results suggest the possibility of fabricating dual functionality 3D scaffolds via high temperature melt extrusion for bone regeneration and infection prevention. | María C´amara-Torres Stacy Duarte Ravi Sinha Ainhoa Egizabal Noelia´Alvarez Maria Bastianini Michele Sisani Paolo Scopece Marco Scatto Alessandro Bonetto Antonio Marcomini Alberto Sanchez Alessandro Patelli Carlos Mota Lorenzo Moroni | 2021 | Bioactive Materials2021，6，4： | 2 |
| 2 | Shear stress-mediated chromatin remodeling provides molecular basis for flow-dependent regulation of gene expression显示文摘 | Illi B Nanni A Scopece A | | 0，，02： | 1 |
| 3 | Epigenetic histone modification and cardiovascular lineage programming in mouse embryonic stem cells exposed to laminar shear stress显示文摘 | Illi B Scopece A Nanni S Farsetti A Morgante L Biglioli P | 2005 | Circ Res2005，96，： | 1 |
| 4 | Epigenetic histone modification and cardiovascular lineage programming in mouse embryonic stem cells exposed to laminar shear stress显示文摘 | ILLI B SCOPECE A NANNI S | 2005 | Circulation Research2005，96，5： | 1 |
| 5 | Patterns of reproductive isolation in Mediterranean deceptive orchids显示文摘 | Scopece G Musacchio A Widmer A | 2007 | Evolution2007，61，11： | 1 |
| 6 | Evolution of postzogytic reproductive isolation in a guide of deceptive orchids显示文摘 | Scopece G Widmer A Cozzolino S | 2008 | The American Naturalist2008，171，3： | 1 |
| 7 | Components of reproductive isolation between Orchis mascula and Orchispauciflora 显示文摘 | SCOPECE G CROCE A LEXER C | 2013 | Evolution2013，67，7： | 1 |
| 8 | Evolution of postzygotic reproductive isolation in a guild of deceptive orchids显示文摘 | SCOPECE G WIDMER A COZZOLINO S | 2008 | Am Nat2008，171，3： | 1 |
| 9 | Epigenetic histone modification and cardiovascular lineage programming in mouse embryonic stem cells exposed to laminar shear stress显示文摘 | Scopece A Nanni S | 2005 | Circ Res2005，96，5： | 1 |
| 10 | Bismuth Modified Gold Nanoelectrode Ensemble for Strip- ping Voltammetric Determination of Lead显示文摘 | Mardegan A Dal Borgo S Scopece P | 2012 | Elec- trochemistry Communications2012，24，： | 1 |
| 11 | Conical nanopore membranes: solvent shaping of nanopores显示文摘 | Paolo Scopece Lane A Baker Paolo Ugo | 2006 | Institute of Physics Publishing2006，，17： | 1 |
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