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		题名	作者	年代	出处	被引量
	1	RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone.	Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M	2013	中国神经肿瘤杂志2013，11，1：	8
	2	The parahippocampal gy- rus links the default-mode cortical network with the medial temporal lobe memory system 显示文摘	Ward AM Schultz AP Huijbers W	2014	Hum Brain Mapp2014，35，3：	1
	3	Veterinary Clinical Pathologists in the Biopharmaceutical Industry显示文摘	Schultze AE Bounous DI Bolliger AP	2008	Vet Clin Pathol2008，37，2：	1
	4	Improvement in rheumatic fever and rheumatic heart disease management and prevention u- sing a health center - based continuous quality improvement ap proach显示文摘	Ralph AP Fittock M Schultz R	2013	BMC Health Serv Res2013，，：	1
	5	Relationship of mar- gin status and radiation dose to recurrence in post-operative vul- var carcinoma显示文摘	Viswanathan AN Pinto AP Schultz D	2013	Gynecol Oncol2013，130，3：	1
	6	Impaired default network functional connectivity in autosomal dominant Alzheimer disease 显示文摘	Chhatwal JP1 Schultz AP Johnson K	2013	Neurology2013，81，8：	1
	7	Mechanical ventilationaggravates transfusion-related acute lung injury induced byMHC-I class antibodies显示文摘	Vlaar AP Wolthuis EK Hofstra JJ Roelofs JJ Boon L Schultz MJ Lutter R Juffermans NP	2010	Intensive Care Med2010，36，5：	1

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