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| 1 | Gastroenterology service in a teaching hospital in rural New Zealand, 1991-2003显示文摘AIM: To retrospectively collect inpatient and outpatient data and to assess the use of endoscopic procedures during the years 1991, 1997 and 2003 to analyse for trends. METHODS: This retrospective survey was conducted in a University-associated Gastroenterology Unit offering secondary and tertiary health care services for a population of approximately 182 000 people in Southern New Zealand. Data collected included patient contacts (inand outpatients), gastroscopic and colonoscopic investigations. RESULTS: We observed a significant increase in the absolute numbers of patient contacts over the years (1991: 2308 vs 1997: 2022 vs 2003: 2783, P < 0.0001) with inflammatory bowel disease, other diseases of the colon, anus and rectum and iron studies related disorders decreasing significantly but liver disease and constipation increasing linearly over time. The use of endoscopy services remained relatively stable but colonoscopic investigations for a positive family history of colorectal cancer increased significantly while more gastroscopies were performed for unexplained anaemia. CONCLUSION: The whole spectrum of gastroenterology contacts was studied. A substantial proportion of colonoscopies and outpatient consultations were undertaken to screen for colorectal cancer. This proportion is likely to grow further. Our fi ndings have implications for the recruitment and training of the next generation of gastroenterologists. | Michael Schultz Andrew Davidson Sarah Donald Bogna Targonska Angus Turnbull Susan Weggery Vicki Livingstone John D Dockerty | 2009 | World Journal of Gastroenterology2009，15，5： | 3 |
| 2 | Lack of correlation between Treg quantification assays in inflammatory bowel disease patients显示文摘AIM:To compare the number of regulatory T-cells( Tregs) measured by flow cytometry with those obtained using a real-time quantitative PCR(q PCR) method in patients suffering from inflammatory bowel disease(IBD).METHODS:Tregs percentages obtained by both flow cytometry and q PCR methods in 35 adult IBD patients,18 out of them with Crohn′s disease(CD)and 17 with ulcerative colitis(UC)were compared to each other as well as to scores on two IBD activity questionnaires using the Harvey Bradshaw Index(HBI)for CD patients and the Simple Colitis Clinical Activity Index(SCCAI)for UC patients.The Treg percentages by flow cytometry were defined as CD4+CD25highCD127lowFOXP3+cells in peripheral blood mononuclear cells,whereas the Treg percentages by q PCR method were determined as FOXP3 promoter demethylation in genomic DNA.RESULTS:We found an average of 1.56%±0.78%Tregs by using flow cytometry,compared to 1.07%±0.53%Tregs by using q PCR in adult IBD patients.There were no significant correlations between either the percentages of Tregs measured by flow cytometry or q PCR and the HBI or SCCAI questionnaire scores in CD or UC patients,respectively.In addition,there was no correlation between Treg percentages measured by q PCR and those measured by flow cytometry(r=-0.06,P=0.73;Spearman Rho).These data suggest that,either Treg-related immune function or the clinical scores in these IBD patients did not accurately reflect actual disease activity.Until the cause(s)for these differences are more clearly defined,the resultssuggest caution in interpreting studies of Tregs in various inflammatory disorders.CONCLUSION:The two methods did not produce equivalent measures of the percentage of total Tregs in the IBD patients studied which is consistent with the conclusion that Tregs subtypes are not equally detected by these two assays. | Gunnar Brandhorst Darinka Todorova Petrova Sebastian Weigand Christoph Eberle Nicolas von Ahsen Jessica Schmitz Frank Christian Schultze Dirk Raddatz Michael Karaus Michael Oellerich Philip D Walson | 2015 | World Journal of Gastroenterology2015，21，11： | 2 |
| 3 | Lariat ethers-synthesis and cation binding of macrocyclic polyethers possessing axially disposed secondary donor groups 显示文摘 | Gokel G W Schultz R A Dishong D M | 1980 | J Chem Soc Chem Commun1980，，： | 2 |
| 4 | Thermal degradation of Poly(methacrylic acid) and Y-Ba-Cu polymethacrylate pre-cursors for preparation of high temperature superconductors显示文摘 | Vonlampe I Schultze D Zygalsky F | 2001 | Polymer Degradation and Stability2001，73，1： | 1 |
| 5 | Determination of effective permittivity and permeability of metamaterials from reflection and transmission coefficients 显示文摘 | Smith D R Schultz S | 2002 | Phys Rev B2002，65，19： | 1 |
| 6 | Starvation induced cross- protection against heat or H2O2 challenge in Escherichia coli 显示文摘 | Jenkins D E Schultz J E Matin A | 1988 | Bacteriology1988，170，： | 1 |
| 7 | Yolk sac ab- sorption and initiation of growth m broilers显示文摘 | Chamblee T N Brake J D Schultz C D | 1992 | Poul Sci1992，71，： | 1 |
| 8 | Effects of selective decontamination of digestive tract on mortality and acquisition of resistant bacteria in intensive care: a randomised controlled trial显示文摘 | de Jonge E D Schultz M J Spanjaard L | 2003 | Lancet2003，362，9389： | 1 |
| 9 | Effect of pH,Aalcium,and Heat Treatment on Curd Tension of Casein Fraction Fortifoed Skim Milk显示文摘 | SCHULTZ D L ASHWORTH U S | 1974 | Journal of Dairy Science1974，57，3： | 1 |
| 10 | Onset and duration of action of rocuronium-from tracheal intubation,through intense block to complete recovery 显示文摘 | SCHULTZ P IBSEN M φSTERGAARD D | 2001 | Acta Anaes- thesiol Scand2001，45，： | 1 |
| 11 | Experimental Verification of a Negative Index of Refraction显示文摘 | SHELBY R A SMITH D R SCHULTZ S | 2001 | Science2001，292，： | 1 |
| 12 | High temperature magnetic properties of 2:17 Sin-Co magnets 显示文摘 | SCHOBINGER D GUTFEISCH O HINZ D MULLER K H SCHULTZ L MARTINEK G | 2002 | Journal of Magnetism and Magnetic Materials2002，，： | 1 |
| 13 | Experimental Verification of a Negative Index of Refraction显示文摘 | SHELBY R A SMITH D R SCHULTZ S | 2001 | Science2001，292，5514： | 1 |
| 14 | Experimental verification of a negative index of refraction显示文摘 | SHELBY R A SMITH D R SCHULTZ S | 2001 | Science2001，292，10： | 1 |
| 15 | Experimental verification of a negative index of refraction显示文摘 | SHELBY R A SMITH D R SCHULTZ S | 2001 | Science2001，292，4： | 1 |
| 16 | Experimental verification of a negative index of refraction 显示文摘 | aSHELBY R A SMITH D R SCHULTZ S | 2001 | Science2001，292，： | 1 |
| 17 | Quantitative determination of fluorinated alkyl substances by large-volume-injection liquid chromatography tandem mass spectrometry-characterization of municipal wastewaters 显示文摘 | Schultz M M Barofsky D F Field J A | 2006 | Environment Science Technology2006，40，： | 1 |
| 18 | Identification of a new class of small molecules that efficiently reactivate latent Epstein - Barr virus显示文摘 | Tikhmyanova N Schultz D C Lee T | 2014 | ACS chemical biology2014，9，3： | 1 |
| 19 | Experimental verification of a negative index of refraction显示文摘 | Smith D R Schultz S | 2001 | Science2001，292，： | 1 |
| 20 | Brain oxygen and metabolism during circulatory arrest with intermittent brief periods of low-flow cardiopulmonary bypass in newborn piglets显示文摘 | Antoni D Shears G | 2006 | J Thorac Cardiovasc Surg2006，132，4： | 1 |
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