|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Occult hepatitis B virus infection among Egyptian blood donors显示文摘AIM:To identify blood donors with occult hepatitis B virus(HBV) infection(OBI) to promote safe blood donation.METHODS:Descriptive cross sectional study was conducted on 3167 blood donors negative for hepatitis B surface antigen(HBsAg),hepatitis C antibody(HCV Ab) and human immunodeficiency virus Ab.They were subjected to the detection of alanine aminotransferase(ALT) and aspartate transaminase(AST) and screening for anti-HBV core antibodies(total) by two different techniques;[Monoliza antibodies to hepatitis B core(Anti-HBc) Plus-Bio-Rad] and(ARC-HBc total-ABBOT).Positive samples were subjected to quantitative detection of antibodies to hepatitis B surface(anti-HBs)(ETI-AB-AUK-3,Dia Sorin-Italy).Serum anti-HBs titers > 10 IU/L was considered positive.Quantitative HBV DNA by real time polymerase chain reaction(PCR)(QIAGEN-Germany) with 3.8 IU/mL detection limit was estimated for blood units with negative serum anti-HBs and also for 32 whose anti-HBs serum titers were > 1000 IU/L.Also,265 recipients were included,34 of whom were followed up for 3-6 mo.Recipients were investigated for ALT and AST,HBV serological markers:HBsAg(ETI-MAK-4,Dia Sorin-Italy),anti-HBc,quantitative detection of anti-HBs and HBV-DNA.RESULTS:525/3167(16.6%) of blood units were positive for total anti-HBc,64% of those were antiHBs positive.Confirmation by ARCHITECT anti-HBc assay were carried out for 498/525 anti-HBc positive samples,where 451(90.6%) confirmed positive.Reactivity for anti-HBc was considered confirmed only if two positive results were obtained for each sample,giving an overall prevalence of 451/3167(14.2%) for total anti-HBc.HBV DNA was quantified by real time PCR in 52/303(17.2%) of anti-HBc positive blood donors(viral load range:5 to 3.5 x 105 IU/mL) with a median of 200 IU/mL(mean:1.8 x 104 ± 5.1 x 104 IU/mL).AntiHBc was the only marker in 68.6% of donors.Univariate and multivariate logistic analysis for identifying risk factors associated with anti-HBc and HBV-DNA positivity among blood donors showed that age above thirty and marriage were the most significant risk factors for prediction of anti-HBc positivity with AOR 1.8(1.4-2.4) and 1.4(1.0-1.9) respectively.Other risk factors as gender,history of blood transfusion,diabetes mellitus,frequent injections,tattooing,previous surgery,hospitalization,Bilharziasis or positive family history of HBV or HCV infections were not found to be associated with positive anti-HBc antibodies.Among anti-HBc positive blood donors,age below thirty was the most significant risk factor for prediction of HBV-DNA positivity with AOR 3.8(1.8-7.9).According to HBV-DNA concentration,positive samples were divided in two groups;group one with HBV-DNA ≥ 200 IU/mL(n = 27) and group two with HBV-DNA < 200 IU/mL(n = 26).No significant difference was detected between both groups as regards mean age,gender,liver enzymes or HBV markers.Serological profiles of all followed up blood recipients showed that,all were negative for the studied HBV markers.Also,HBV DNA was not detected among studied recipients,none developed post-transfusion hepatitis(PTH) and the clinical outcome was good.CONCLUSION:OBI is prevalent among blood donors.Nucleic acid amplification/HBV anti core screening should be considered for high risk recipients to eliminate risk of unsafe blood donation. | Zeinab N Said Manal H El Sayed Iman I Salama Enas K Aboel-Magd Magda H Mahmoud Maged El Setouhy Faten Mouftah Manal B Azzab Heidi Goubran Amal Bassili Gamal E Esmat | 2013 | World Journal of Hepatology2013，5，2： | 4 |
| 2 | Effect of Commiphora mukul gum resin on hepatic marker enzymes,lipid peroxidation and antioxidants status in pancreas and heart of streptozotocin induced diabetic rats显示文摘Objective:To study the antioxidant efficacy of Commiphora mukul(C.mukul) gum resin ethanolic extract in streptozotocin(STZ) induced diabetic rats.Methods:The male Wistar albino rats were randomly divided into four groups of eight animals each:Control group(C),CM-treated control group(C_+CMEE),Diabetic control group(D),CM- treated diabetic group(D_+CMEE).Diabetes was induced by intraperitoneal injection of STZ(55 mg/kg/ bwt).After being confirmed the diabetic rats were treated with C.mukul gum resin ethanolic extract(CMEE) for 60 days.The biochemical estimations like antioxidant,oxidative stress marker enzymes and hepatic marker enzymes of tissues were performed.Results:The diabetic rats showed increased level of enzymatic activities aspartate aminotransaminase(AST),alanine aminotransaminase(ALT) in liver and kidney and oxidative markers like lipid peroxidation(LPO) and protein oxidation(PO) in pancreas and heart. Antioxidant enzyme activities were significantly decreased in the pancreas and heart compared to control group.Administration of CMEE(200 mg/kg bw) to diabetic rats for 60 days significantly reversed the above parameters towards normalcy.Conclusions:In conclusion,our data indicate the preventive role of C.mukul against STZ-induced diabetic oxidative stress;hence this plant could be used as an adjuvant therapy for the prevention and/or management of diabetes and aggravated antioxidant status. | Ramesh B Karuna R Sreenivasa Reddy S Haritha K Sai Mangala D Sasi Bhusana Rao B Saralakumari D | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，11： | 3 |
| 3 | Autonomic Dysfunction as a Delayed Sequelae of Acute Ethylene Glycol Ingestion 显示文摘 | Sayed S Satish K | 2011 | J Med Toxicol2011，17，： | 1 |
| 4 | Effect of carbon nanotubes content on the mechanical of CNT-re- inforced aluminium composities 显示文摘 | EASWI A M K MORSI K SAYED A | 2010 | Composites Science and Technology2010，70，16： | 1 |
| 5 | Au nanoparticles target cancer显示文摘 | Jain P K El - Sayed I H and El - Sayed M A | 2007 | Nano Today2007，2，1： | 1 |
| 6 | Synthesis and characterization of sulfated titania solid acid catalysts显示文摘 | AJAY K SETHURAMAN R SAI P R | 1998 | Ind Eng Chem Res1998，37，： | 1 |
| 7 | Traveling- wave -based fault- location scheme for multiend- aged underground cable system显示文摘 | GILANY M G IBRAHIM D K SAYED E | 2007 | IEEE Transactions on Power Delivery2007，22，1： | 1 |
| 8 | Diagnosing cervical biopsies in adolescents:The use of p16 immunohistochemistry to improve reliability and reproducibility显示文摘 | Sayed K Korourian S Ellison DA | 2007 | J Low Genit Tract Dis2007，11，3： | 1 |
| 9 | Cogging torque optimization in surface-mounted permanent-magnet motors by using design of experiment显示文摘 | ABBASZADEH K REZAEE ALAM F SAIED S A | 2011 | Energy Conversion and Management2011，52，10： | 1 |
| 10 | Inhibition of apoptosis by pentachlorophenol in v-myc--transfected rat fiver epithelial cells: relation to down--regulation of gap junctional intercellular communication显示文摘 | Sai K Kang KS Hirose A | 2001 | Cancer Lett2001，173，2： | 1 |
| 11 | pre-Continuity and D(c,P)-continuity in fuzzifying topology显示文摘 | Abd El-Hakeim K M Zeyada F M Sayed O R | 2001 | Fuzzy Sets and Systems2001，119，： | 1 |
| 12 | Upconverting luminescent nanoparticles for use in bioconjugation and bioimaging 显示文摘 | Heike S M Peter K Sayed M S | 2010 | Current Opinion in Chemical Biology2010，14，5： | 1 |
| 13 | Hierarchical porous polymer scaffolds from block copolymers显示文摘 | Hiroaki Sai K W T K | 2013 | Science2013，341，6145： | 1 |
| 14 | Gravity balancing leg ortho-sis and its performance evaluation 显示文摘 | Sai K B Sunil K A Abbas F | 2006 | IEEE Transactions on Robotics2006，22，6： | 1 |
| 15 | Molecular interaction study of binary mixtures of methyl benzoate : viscometric and ultrasonic study 显示文摘 | RATHNAM M V SAYED R T BHANUSHALI K R | 2012 | J Mol Liq2012，166，1： | 1 |
| 16 | Fabrication and properties of dispersed carbon nanotubealuminum composites显示文摘 | Esawi A.M.K Morsi K Sayed A Gawad A.A and Borah P | 2009 | Mater Sci Eng α-Struct2009，，： | 1 |
| 17 | Additive effects of drug transporter genetic polymorphisms on irinotecan pharmacokinetics/pharmacody- namics in Japanese cancer patients显示文摘 | Sai K Saito Y Maekawa K | 2010 | Cancer Chemother Pharma- col2010，66，1： | 1 |
| 18 | Fouling and cleaning of membranes in the ultrafiltration of the aqueous extract of soy flour 显示文摘 | Sayed Razavi S K Harris J L Sherkat F | 1996 | J Membr Sci1996，114，： | 1 |
| 19 | A low- voltage CMOS low - dropout regulator with enhanced loop response显示文摘 | Ka Nang Leung Philip K T Mok Sai Kit Lau | 2004 | IEEE ISCAS2004，，12： | 1 |
| 20 | Studies on Rana tigerina skin collagen显示文摘 | SAI K P BABU M | 2001 | Com- parative Biochemistry and Part and Molecular Biology2001，128，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员