6篇
您的检索式：作者名="Savas Ceylan"
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| 1 | Therapeutic effect of caffeic acid phenethyl ester on cerulein-induced acute pancreatitis显示文摘AIM: To evaluate the therapeutic role of caffeic acid phenethyl ester (CAPE) in a rat model of ceruleaninduced acute pancreatitis (AP).METHODS: Seventy male Wistar albino rats were divided into seven groups. Acute edematous pancreatitis was induced by subcutaneous cerulein injection (20 μg/kg) four times at 1-h intervals. CAPE (30 mg/kg) was given by subcutaneous injection at the beginning (CAPE 1 group) and 12 h after the last cerulein injection (CAPE 2 group). Serum amylase, lipase, white blood cell count, and tumor necrosis factor (TNF)-α levels were measured, and pancreatic histopathology was assessed. RESULTS: In the AP group, amylase and lipase levels were found to be elevated and the histopathological evaluation showed massive edema and inflammation of the pancreas, with less fatty necrosis when compared with sham and control groups. Amylase and lipase levels and edema formation decreased signif icantly in the CAPE therapy groups (P < 0001); especially in the CAPE 2 group, edema was improved nearly completely (P = 0001). Inflammation and fatty necrosis were partially recovered by CAPE treatment. The pathologicalresults and amylase level in the placebo groups were similar to those in the AP group. White blood cell count and TNF-α concentration was nearly the same in the CAPE and placebo groups.CONCLUSION: CAPE may be useful agent in treatment of AP but more experimental and clinical studies are needed to support our observation of benef icial effects of CAPE before clinical usage of this agent. | Mehmet Buyukberber M Cemil Savas Cahit Bagci Mehmet Koruk Murat T Gulsen Ediz Tutar Tugba Bilgic Nurdan Ceylan | 2009 | World Journal of Gastroenterology2009，15，41： | 4 |
| 2 | Topical application of mitomycin C prevents epineural scar formation in rats显示文摘 | Konuralp Ilbay Volkan Etus Kursat Yildiz Gul Ilbay Savas Ceylan | 2005 | Neurosurgical Review2005，，2： | 1 |
| 3 | Success of endoscopic third ventriculostomy in children less than 2 years of age显示文摘 | Volkan Etus Savas Ceylan | 2005 | Neurosurg Rev2005，28，： | 1 |
| 4 | Imaging findings of vascular lesions in the head and neck 显示文摘 | Gtineyli S Ceylan N Sava R | 2014 | Diagn Interv Radiol2014，19，3： | 1 |
| 5 | Topical application of mitomycin C prevents epineural scar formation in rats显示文摘 | Konuralp Ilbay Volkan Etus Kursat Yildiz Gul Ilbay Savas Ceylan | 2005 | Neurosurgical Review2005，，2： | 1 |
| 6 | Morinda citrifolia L. (noni) and memantine attenuate periventricular tissue injury of the fourth ventricle in hydrocephalic rabbits显示文摘This study was designed to evaluate the neuroprotective effects of Morinda citrifolia L. (Rubiaceae), commonly known as noni, and memantine (a N-methy-D-aspartate receptor inhibitor) on hydrocephalus-induced neurodegenerative disorders. Kaolin was injected into the cistern magna of male adult New Zealand rabbits to establish a hydrocephalus animal model. Memantine (20 mg/kg, intraperitoneally; memantine-treated group) or noni (5 mL/kg, intragastrically; noni-treated group) was administered daily for 2 weeks. Microtubule-associated protein-2 and caspase-3 immunohistochemistry were performed to detect neuronal degeneration and apoptosis in the periventricular tissue of the fourth ventricle of rabbits. Microtubule-associated protein-2 staining density was significantly decreased in the hydrocephalic group, while the staining density was significantly increased in the memantine- and noni-treated groups, especially in the noni-treated group. Noni treatment decreased the number of caspase-3-positive cells in rabbits with hydrocephalus, while memantine had no effect. These findings suggest that noni exhibits more obvious inhibitory effects on hydrocephalus-induced neurodegenerative disorders than memantine in periventricular tissue of the fourth ventricle. | Sibel Kktürk Süreyya Ceylan Volkan Etus Nezih Yasa Savas Ceylan | 2013 | Neural Regeneration Research2013，8，9： | 0 |
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