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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies显示文摘在地岬基因的 Oncogenic 变化在人的癌症是很普通的,导致有描绘得好的选择优点,而且不太听说得好的危险的房间。我们执行了一幅大规模 loss-of-function 屏幕识别被转变 KRAS 的结肠癌房间,然而并非由缺乏这 oncogene 的衍生物要求的基因。最高得分的基因然后在 KRAS 变异、野类型的癌症房间的一块更大的面板被测试。表示 oncogenic KRAS 的癌症房间被发现高度依赖于抄写因素 GATA2 和 DNA 复制开始管理者 CDC6。与已知的目标用许多药扩大这分析,我们发现有变异的 KRAS 的癌症房间与 topoisomerase 抑制显示出选择嗜好到 proteasome 功能,以及合成致命性。联合指向引起的这些功能改善了相对野类型的房间 KRAS 变异的房间杀死。这些观察建议新奇目标和在地岬变异的癌症为最佳的效果联合存在治疗的新方法,它传统地被看作对治疗高度倔强。 | Michael Steckel Miriam Molina-Arcas Britta Weigelt Michaela Marani Patricia H Warne Hanna Kuznetsov Gavin Kelly Becky Saunders Michael Howell Julian Downward David C Hancock | 2012 | Cell Research2012，22，8： | 5 |
| 3 | Supernumerary Spacing of Rainbows Produced by an Elliptical-cross-section Cylinder II:Experiment显示文摘 | Adler C L Phipps D Saunders K W | 2001 | Appl Opt2001，40，15： | 1 |
| 4 | Information acquisition during deci- sion making processes: an exploratory study of decision roles in media selection 显示文摘 | Jones J W Saunders C Mcleod R | 1994 | IEEE Trans Eng Manage1994，41，1： | 1 |
| 5 | Effect of growth hormone administration and dietary protein intake on insulin-like growth factor I and growth hormone receptor mRNA expression in porcine liver, skeletal muscle, and adipose tissue显示文摘 | Brameld J M Alkinson J L Saunders J C | | J Anim0，，： | 1 |
| 6 | Information acquisition in group decision making 显示文摘 | Saunders C Miranda S | 1998 | Information & Management1998，34，1： | 1 |
| 7 | Charge separation during the fragmentation of rime and frost 显示文摘 | Saunders C P R Hickson H Malone M D Richtofen J V | 1993 | Atmospheric Research1993，83，： | 1 |
| 8 | Reactive oxygenspecies mediate lysophosphatidic acid induced signaling in ovarian cancer cells显示文摘 | Saunders J A Rogers L C Klomsiri C | | 0，，12： | 1 |
| 9 | Modulation of neurotoxic behavior in F-344 rats by temporal disposition of benzo(a)pyrene显示文摘 | SAUNDERS C R RAMESH A SHOCKLEY D C | 2002 | Toxicol Lett2002，129，12： | 1 |
| 10 | Human urocortin II, a new CRF -related peptide, displays selective CRF (2) -mediated action on gastric transit in rats 显示文摘 | Million M Maillot C Saunders P | 2002 | Am J Physiol Gastrointest Liver Physiol2002，282，1： | 1 |
| 11 | Hyperfractionated or accelerated radiotherapy in lung cancer: an individual patient data meta-analysis显示文摘 | Mauguen A Le Pechoux C Saunders MI | 2012 | J Clin Oncol2012，30，22： | 1 |
| 12 | Effects ofroads on landscape structure within nested ecological units of theNorthern Great Lakes Region,USA显示文摘 | SAUNDERS S C MISLIVETS M R CHEN Jiquan | 2002 | Biological conservation2002，103，2： | 1 |
| 13 | Simulation of the dynamic behaviour of a tractor-oscillating subsoiler system 显示文摘 | Shahgoli G Fielke J Saunder C | 2010 | Biosystems Engineering2010，106，： | 1 |
| 14 | The ovine insulin-like growth factor-lgene:characterization,expression and identification of a putative promoter显示文摘 | DICKSON M C SAUNDERS J C GILMOUR R S | 1991 | J Mol Endocrinol1991，6，： | 1 |
| 15 | PrP genotypes of atypical scrapie cases in Great Britain 显示文摘 | Saunders G C Cawthraw S Mountjoy S J | 2006 | J Gen Virol2006，87，11： | 1 |
| 16 | Nurses implementation of guidelines for ventilator-associated pneumonia from the centers for disease control and prevention显示文摘 | Cason C L Tyner T Saunders S | 2007 | Am J Crit Care2007，16，1： | 1 |
| 17 | Marshaling resources to form small new ventures: Toward a more holistic understanding of entrepre-neurial support显示文摘 | Hanlon D and Saunders C | 2007 | Entrepreneurship Theory and Practice2007，31，4： | 1 |
| 18 | LSQR:an algorithm for sparse linear equations and sparse least squares显示文摘 | Paige C C Saunders M A | | 0，，1： | 1 |
| 19 | Precision in reporting the dose given in a course of radiotherapy 显示文摘 | Dische S Saunders MI Williams C | 1993 | Radiotherapy Oncol1993，29，3： | 1 |
| 20 | ICEPAK- modeling the ice-filling and ice-melting processes of thermal energy storage tanks 显示文摘 | Stewart W E Jr Gute G D Saunders C K | 1995 | ASHRAE Transactions1995，101，1： | 1 |
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