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| 1 | Predictive value of multi-detector computed tomography for accurate diagnosis of serous cystadenoma:Radiologic-pathologic correlation显示文摘AIM:To identify multi-detector computed tomography(MDCT) features most predictive of serous cystadenomas(SCAs),correlating with histopathology,and to study the impact of cyst size and MDCT technique on reader performance.METHODS:The MDCT scans of 164 patients with surgically verified pancreatic cystic lesions were reviewed by two readers to study the predictive value of various morphological features for establishing a diagnosis of SCAs.Accuracy in lesion characterization and reader conf idence were correlated with lesion size(≤3cm or≥3cm) and scanning protocols(dedicated vs routine).RESULTS:28/164 cysts(mean size,39 mm;range,8-92mm) were diagnosed as SCA on pathology.The MDCT features predictive of diagnosis of SCA were microcystic appearance(22/28,78.6%),surface lobulations(25/28,89.3%) and central scar(9/28,32.4%).Stepwise logistic regression analysis showed that only microcystic appearance was signifi cant for CT diagnosis of SCA(P=0.0001).The sensitivity,specificity and PPV of central scar and of combined microcystic appearance and lobulations were 32.4%/100%/100% and 68%/100%/100%,respectively.The reader confidence was higher for lesions>3cm(P=0.02) and for MDCT scans performed using thin collimation(1.25-2.5mm) compared to routine 5 mm collimation exams(P>0.05).CONCLUSION:Central scar on MDCT is diagnostic of SCA but is seen in only one third of SCAs.Microcystic morphology is the most significant CT feature in diagnosis of SCA.A combination of microcystic appearance and surface lobulations offers accuracy comparable to central scar with higher sensitivity. | Anjuli A Shah Nisha I Sainani Avinash Kambadakone Ramesh Zarine K Shah Vikram Deshpande Peter F Hahn Dushyant V Sahani | 2009 | World Journal of Gastroenterology2009，15，22： | 11 |
| 2 | Intravenous vitamin C as adjunctive therapy for enterovirus/rhinovirus induced acute respiratory distress syndrome显示文摘We report a case of virus-induced acute respiratory distress syndrome(ARDS) treated with parenteral vitamin C in a patient testing positive for enterovirus/rhinovirus on viral screening. This report outlines the first use of high dose intravenous vitamin C as an interventional therapy for ARDS, resulting from enterovirus/rhinovirus respiratory infection. From very significant preclinical research performed at Virginia Commonwealth Universitywith vitamin C and with the very positive results of a previously performed phase Ⅰ safety trial infusing high dose vitamin C intravenously into patients with severe sepsis, we reasoned that infusing identical dosing to a patient with ARDS from viral infection would be therapeutic. We report here the case of a 20-year-old, previously healthy, female who contracted respiratory enterovirus/rhinovirus infection that led to acute lung injury and rapidly to ARDS. She contracted the infection in central Italy while on an 8-d spring break from college. During a return flight to the United States, she developed increasing dyspnea and hypoxemia that rapidly developed into acute lung injury that led to ARDS. When support with mechanical ventilation failed, extracorporeal membrane oxygenation(ECMO) was initiated. Twelve hours following ECMO initiation, high dose intravenous vitamin C was begun. The patient's recovery was rapid. ECMO and mechanical ventilation were discontinued by day-7 and the patient recovered with no long-term ARDS sequelae. Infusing high dose intravenous vitamin C into this patient with virus-induced ARDS was associated with rapid resolution of lung injury with no evidence of post-ARDS fibroproliferative sequelae. Intravenous vitamin C as a treatment for ARDS may open a new era of therapy for ARDS from many causes. | Alpha A Fowler Ⅲ Christin Kim Lawrence Lepler Rajiv Malhotra Orlando Debesa Ramesh Natarajan Bernard J Fisher Aamer Syed Christine DeWilde Anna Priday Vigneshwar Kasirajan | 2017 | World Journal of Critical Care Medicine2017，6，1： | 9 |
| 3 | Clinical implications of diabetes in chronic liver disease:Diagnosis,outcomes and management,current and future perspectives显示文摘Diabetes mellitus(DM)is common in liver cirrhosis(LC).The pathophysiological association is bidirectional.DM is a risk factor of LC and LC is a diabetogenic condition.In the recent years,research on different aspects of the association DM and LC has been intensified.Nevertheless,it has been insufficient and still exist many gaps.The aims of this review are:(1)To discuss the latest understandings of the association of DM and LC in order to identify the strategies of early diagnosis;(2)To evaluate the impact of DM on outcomes of LC patients;and(3)To select the most adequate management benefiting the two conditions.Literature searches were conducted using Pub Med,Ovid and Scopus engines for DM and LC,diagnosis,outcomes and management.The authors also provided insight from their own published experience.Based on the published studies,two types of DM associated with LC have emerged:Type 2 DM(T2 DM)and hepatogenous diabetes(HD).High-quality evidences have determined that T2 DM or HD significantly increase complications and death pre and post-liver transplantation.HD has been poorly studied and has not been recognized as a complication of LC.The management of DM in LC patients continues to be difficult and should be based on drug pharmacokinetics and the degree of liver failure.In conclusion,the clinical impact of DM in outcomes of LC patients has been the most studied item recently.Nevertheless many gaps still exist particularly in the management.These most important gaps were highlighted in order to propose future lines for research. | Diego García-Compeán Emanuela Orsi Ramesh Kumar Felix Gundling Tsutomu Nishida Jesús Zacarías Villarreal-Pérez Ángel N Del Cueto-Aguilera JoséA González-González Giuseppe Pugliese | 2022 | World Journal of Gastroenterology2022，28，8： | 4 |
| 4 | From minimal to maximal surgery in the treatment of hepatocarcinoma:A review显示文摘Hepatocellular carcinoma represents one of the most challenging frontiers in liver surgery. Surgeons have to face a broad spectrum of aspects,from the underlying liver disease to the new surgical techniques. Safe liver resection can be performed in patients with portal hypertension and well-compensated liver function witha 5-year survival rate of 50%,offering good longterms results in selected patients. With the advances in laparoscopic surgery,major liver resections can be performed with minimal harm,avoiding the wound and leak complications related to the laparotomies. Studies have shown that oncological margins are the same as in open surgery. In patients submitted to liver resection(either laparoscopic or open) who experience recurrence,re-resection or salvage liver transplantation has been showing to be an alternative approach in well selected cases. The decision making approach to the cirrhotic patient is becoming more complex and should involve hepatologists,liver surgeons,radiologists and oncologists. Better understanding of the different risk factors for recurrence and survival should be aimed in these multidisciplinary discussions. We here in discuss the hot topics related to surgical risk factors regarding the surgical treatment of hepatocellular carcinoma: anatomical resection,margin status,macrovascular tumor invasion,the place of laparoscopy,salvage liver transplantation and liver transplantation. | Marcos Vinicius Perini Graham Starkey Michael A Fink Ramesh Bhandari Vijayaragavan Muralidharan Robert Jones Christopher Christophi | 2015 | World Journal of Hepatology2015，7，1： | 4 |
| 5 | A genetic approach for nesting of 2-D parts in 2-D sheets using genetic and heuristic algorithms 显示文摘 | RAMESH B A RAMESH B N | 2001 | Computer-Aided Design2001，33，12： | 1 |
| 6 | Fair Value Disclosures Bank Holding Companies显示文摘 | Eccher A Ramesh K Thiagarajan S R | 1996 | Journal of Accounting and Economics1996，22，13： | 1 |
| 7 | Error Compensation in Machine Tools-A Review Part I: Geometric, Cutting-force Induced and Fixture-dependent Errors显示文摘 | Ramesh R Mannan M A Poo A N | 2000 | International Journal of Machine Tools & Manufacture2000，40，： | 1 |
| 8 | Multiferroics: Progress and Prospects in Thin Films显示文摘 | Ramesh R Spaldin N A | 2007 | Nature Mater2007，6，： | 1 |
| 9 | Multiferroics: Progress and prospects in thin films 显示文摘 | Ramesh R Spaldin N A | 2007 | Nature Materials2007，，6： | 1 |
| 10 | Beta-D-glucoside suppresses tumor necrosis factor-induced activation of nuclear transcription factor kappa B but potentiates apoptosis显示文摘 | Sarkar A Sreenivasan Y Ramesh GT | 2004 | J Biol Chem2004，279，： | 1 |
| 11 | Modulation of neurotoxic behavior in F-344 rats by temporal disposition of benzo(a)pyrene显示文摘 | SAUNDERS C R RAMESH A SHOCKLEY D C | 2002 | Toxicol Lett2002，129，12： | 1 |
| 12 | Error compensation in machine tools-a review: Part I: geometric, cutting-force induced and fixture-dependent errors 显示文摘 | Ramesh R Mannan M A Poo A N | 2000 | International Journal of Machine Tools and Manufacture2000，40，9： | 1 |
| 13 | Application of a convenient DNA extraction method and multiplex PCR for the direct detection of Staphylococcus aureus and Yersinia enterocolitica in milk samples显示文摘 | Ramesh A Padmapriya B P Chrashekar A | 2002 | Mol Cell Probes2002，16，4： | 1 |
| 14 | Friction and wear behaviour of cast A1 6063 based in situ metal matrix composites 显示文摘 | RAMESH C S AHAMED A | 2011 | Wear2011，271，： | 1 |
| 15 | Graphite nanoplatelet-epoxy composite thermal interface materials显示文摘 | Yu A P Ramesh P hkis M E Bekyarova E Haddon R C | | 0，，： | 1 |
| 16 | A technique for measuring the dynamic behavior of materials at high temperatures显示文摘 | LENNON A M RAMESH K T | | 0，，12： | 1 |
| 17 | Adsorption of inorganic and organic arsenic from aqueous solutions by polymeric A1/Fe modified montmorillonite显示文摘 | Ramesh A Hasegawa H Maki T | 2007 | Separation and Purification Technology2007，56，1： | 1 |
| 18 | The P-POSSUM scoring systems for predicting the mortality of neurosurgical patients undergoing craniotomy:further validation of usefulness and application across healthcare systems显示文摘 | Mercer S Guha A Ramesh V | 2013 | Indian J Anaesth2013，57，6： | 1 |
| 19 | Dental pulp stem cells immobilized in alginate microsphees for applications in bone tissue engineering显示文摘 | Kanafi MM Ramesh A Guota PK | 2014 | Int Endod J2014，47，7： | 1 |
| 20 | Multiferroics: Progress and prospects in thin films显示文摘 | Ramesh R Spaldin A N | 2007 | Nature Mater2007，6，： | 1 |
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