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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Optical diagnosis of small colorectal polyps at routine colonoscopy (Detect InSpect ChAracterise Resect and Discard; DISCARD trial): a prospective cohort study显示文摘 | Ana Ignjatovic James E East Noriko Suzuki Margaret Vance Thomas Guenther Brian P Saunders | 2009 | Lancet Oncology2009，，： | 2 |
| 3 | Charge separation during the fragmentation of rime and frost 显示文摘 | Saunders C P R Hickson H Malone M D Richtofen J V | 1993 | Atmospheric Research1993，83，： | 1 |
| 4 | Nature of the spermatogenic arrest in Dazl -/-mice显示文摘 | SCHRANS - STASSEN B H SAUNDERS P T COOKE H J | 2001 | Biol Re- prod2001，65，3： | 1 |
| 5 | Killer cell immunoglobu- lin-like receptor 3DL1 polymorphism defines distinct hierarchies of HLA class I recognition显示文摘 | Saunders PM Pymm P Pietra G | 2016 | J Exp Med2016，213，5： | 1 |
| 6 | An assessment of microbial coronal leakage in teeth root filled with gutta-percha and three different sealers显示文摘 | Chailertvanitkul P Saunders WP Mackenzie D | 1996 | Int Endod J1996，29，6： | 1 |
| 7 | Human urocortin II, a new CRF -related peptide, displays selective CRF (2) -mediated action on gastric transit in rats 显示文摘 | Million M Maillot C Saunders P | 2002 | Am J Physiol Gastrointest Liver Physiol2002，282，1： | 1 |
| 8 | Particulate matter- induced airway hyperresponsiveness is lymphocyte dependent 显示文摘 | Saunders V Breysse P Clark J | 2010 | Environ Health Perspect2010，118，5： | 1 |
| 9 | Uncertainty Budgets for Calibration of Radiation Thermometers below the Silver Point 显示文摘 | Saunders P Fischer J Sadli M | 2008 | Int J Thermophys2008，29，3： | 1 |
| 10 | Spatial aggrega tion and temporal migration of free-living stages of the parasitic nematode Trichostrongylus tenuis 显示文摘 | Saunders L M Tompkins D M Hudson P J | 2000 | Functional Ecology2000，14，： | 1 |
| 11 | Microblogging the ISMB:a new approach to conference reporting显示文摘 | Saunders N Beltrao P Jensen L | | 0，，01： | 1 |
| 12 | Usefulness of anti-infective lock solutions for catheter-related bloodstream infections显示文摘 | Kim EY Saunders P Yousefzadeh N | 2010 | Mt Si- nai J Med2010，77，5： | 1 |
| 13 | Influence of stacking- fault energy on high temperature creep of alpha titanium alloys 显示文摘 | Guo Z Miodownik A P Saunders N | 2006 | Scripta Materialia2006，54，12： | 1 |
| 14 | Three-body wear associated with three ceramics and enamel 显示文摘 | Al-Hiyasat A S Saunders W P Smith G M | 1999 | J Prosthet Dent1999，82，： | 1 |
| 15 | The mammalian target of rapamycin inhibitor RAD001 ( everolimus ) synergizes with chemotherapeutic agents, ionizing radiation and proteasome inhibitors in pre - B acute lymphocytic leukemia显示文摘 | Saunders P Cisterne A Weiss J | 2011 | Haematologica2011，96，： | 1 |
| 16 | Lipid hydrolysis and peroxidation in injured spinal cord:partial protection with methylprednisolone or vitamin E and selenium显示文摘 | Anderson DK Saunders RD Demediuk P | 1985 | Cent Nerv Syst Trauma1985，2，4： | 1 |
| 17 | Investigation of human enamel wear against four dental ceramics and gold显示文摘 | AL-Hiyasat A S Saunders W P | 1998 | Journal of Dentistry1998，26，： | 1 |
| 18 | Metastable lattice stabilities for the elements显示文摘 | Saunders N Miodowik A P Dinsdale A T | 1988 | Calphad-Computer Coupling of Phase Diagrams and thermochemistry1988，12，： | 1 |
| 19 | Interpreting the effects of small uncharged solutes on protein - folding equilibria 显示文摘 | DAVIS S P R SAUNDERS A J ERIE D A | 2001 | Annual Reviews Biophysics Biomolecular Structure2001，30，1： | 1 |
| 20 | A note on a sufficient-decrease criterion for a nonderivative steplength procedure 显示文摘 | Gill E P Murry Saunders W Wright H M | 1982 | Mathematical Programming1982，23，： | 1 |
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