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| 1 | Aspartate transaminase to platelet ratio index in hepatitis C virus and Schistosomiasis coinfection显示文摘AIM: To assess the diagnostic accuracy,of aminotransferase-to-platelet ratio index(APRI) alone and with antischistosomal antibody(Ab) in patients with hepatitis C virus(HCV) and schistosomiasis coinfection. METHODS: This retrospective study included medical records of three hundred and eighty three Egyptianmen patients who had undergone percutaneous liver biopsy between January 2006 to April 2014 in tertiary care hospital in Qatar for diagnosis or monitoring purpose were selected. Data of patients > 18 years of age were included in the study. The values of HCV RNA titer and antischistosomal antibody titer were also taken into consideration. Patients were excluded from the study if they had any other concomitant chronic liver disease,including; history of previous antiviral or interferon therapy,immunosuppressive,therapy,chronic hepatitis B infection,human immunodeficiency virus co-infection,autoimmune hepatitis,decompensated liver disease,hepatocellular carcinoma,prior liver transplantation,and if no data about the liver biopsy present. RESULTS: Median age of patients was 46 years. About 7.1% had no fibrosis,whereas 30.4%,37.5%,20.4%,and 4.6% had fibrosis of stage Ⅰ,Ⅱ,Ⅲ,and Ⅳ respectively. In bivariate analysis,APRI score,levels of AST,platelet count and age of patient showed statistically significant association with liver fibrosis(P < 0.0001); whereas antischistosomal antibody titer(P = 0.52) and HCV RNA titer(P = 0.79) failed to show a significant association. The respective AUC values for no fibrosis,significant fibrosis,severe fibrosis and cirrhosis of APRI score were 63%,73.2%,81.1% and 88.9% respectively. This showed good sensitivity and specificity of APRI alone for grading of liver fibrosis. But the inclusion of anti-Schistosoma antibody did not improve the prediction of fibrosis stage. CONCLUSION: The study results suggest that noninvasive biochemical markers like APRI are sensitive and specific in diagnosing the degree of fibrosis and cirrhosis in patients with coinfection of HCV and schistosomiasis as compared to biopsy. The addition of antischistosomal Ab to APRI did not improve sensitivity for predicting the degree of cirrhosis. | Moutaz Derbala Mohammed Elshiekh Elbadri Aliaa Mohamed Amer Saad Al Kaabi Khaleel Hassan Sultan Yasser Medhat Kamel Eman Hassan Satti Elsayed Tony Yervant Avades Prem Chandra Fatma M Shebl | 2015 | World Journal of Gastroenterology2015，21，46： | 2 |
| 2 | Axiomatic foundation of the analytic hierarchyprocess显示文摘 | SATTY T L | 1986 | Management Science1986，32，7： | 1 |
| 3 | Uncertainty and Rank Order in the Analytic Hierarchy Process显示文摘 | Satty T L Vargas LG | 1987 | European Journal of Operational Research1987，，： | 1 |
| 4 | Cystic lymphangioma of the colon显示文摘 | Dr. M. Camilleri M.D. M.R.C.P. (U.K.) M. B. Satti D.C.P M.R.C. Path. C. B. Wood F.R.C.S | 1982 | Diseases of the Colon & Rectum1982，，8： | 1 |
| 5 | Evaluation of BACTEC MGIT960 system for recovery of Mycobacterium tuberculosis complex in Pakistan显示文摘 | Satti L Ikram A Abbasi S | 2010 | Malaysian J Microbool2010，6，2： | 1 |
| 6 | Inconsistency and Rank Preservation 显示文摘 | Satty T L | 1984 | Journal of Mathematical Psychology1984，，28： | 1 |
| 7 | Axiomatic foundation of the analytic hierarchy process显示文摘 | Satty TL | 1986 | Management Science1986，32，7： | 1 |
| 8 | Procedures for synthesizing ratio judgments显示文摘 | Acezel J Satty T L | 1983 | Journal of Mathematical Psychology1983，27，： | 1 |
| 9 | Abdorminal tuberculosis in Sandi Arabia:a clinico-pathological study of 65 cases显示文摘 | Al-Qyirain AA Facharzt A Satti MB | 1993 | Am J Gastroenterol1993，88，1： | 1 |
| 10 | 显示文摘 | | 1987 | Eropean Journal of Operational Research1987，，32： | 1 |
| 11 | Macrophage migration inhibitory factor, Toll-like receptor 4, and CD14 polymorphisms with altered expression levels in patients with ulcerative colitis显示文摘 | Gunisetty Sivaram Santosh K. Tiwari Avinash Bardia Farha Anjum Satti Vishnupriya Aejaz Habeeb Aleem A. Khan | 2012 | Human Immunology2012，，2： | 1 |
| 12 | A scaling method for priorities in hierarchy structures 显示文摘 | SATTY T L | 1977 | J of Math Psychology1977，，15： | 1 |
| 13 | How to Make a Decision: The Analytical Hierarchy Process 显示文摘 | Satty T L | 1990 | European Journal of Operational Research1990，，2： | 1 |
| 14 | Ranking by eigenvector versus other methods in the analytic hierarchy process 显示文摘 | SATTY T L | 1998 | Applied Mathematics Letters1998，11，4： | 1 |
| 15 | How to handle dependence with the analytic hierarchy process显示文摘 | SATTY T L | 1987 | Mathematical Modelling1987，9，345： | 1 |
| 16 | A scaling method for priorities in hierarchical structutes显示文摘 | Satty T L | 1978 | Journal of Mathematical Psychology1978，1，1： | 1 |
| 17 | Specific immunoglobulin measurements related to exposure and resistance to Schistosoma mansoni infection in Sudanese canal cleaners显示文摘 | Satti MZ Lind P Vennervald B J | 1996 | Clin Exp Immunol1996，106，1： | 1 |
| 18 | A theory of analytrical hierarchies applied to political candidacy 显示文摘 | Satty T L Bennett J P | 1997 | Behavioral Science1997，22，4： | 1 |
| 19 | How to make a decision: The analytic hi- erarchy process显示文摘 | Satty T L | 1990 | European Journal of Operational Reasearch1990，48，1： | 1 |
| 20 | Uncertainties and Rank Order in the Analytic Hierarchy Process 显示文摘 | Satty T L Vargas | 1987 | European Journal of Operation Research1987，32，： | 1 |
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