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| 1 | Neuroendocrine carcinoma of the extrahepatic bile duct: Case report and literature review显示文摘Neuroendocrine carcinoma (NEC) of the extrahepatic bile duct is rare, and only 22 cases have been reported. Only two of these were large-cell NEC (LCNEC); the vast majority were small-cell NEC. Here, we report a third case of LCNEC of the extrahepatic bile duct. A 76-year-old male presented to a local hospital with painless jaundice. Imaging studies revealed a tumor at the hepatic hilum. The patient underwent right hepatic lobectomy, bile duct resection, and cholecystectomy. The resection specimen showed a 5.0-cm invasive neoplasm involving the hilar bile ducts and surrounding soft tissue. Histologically, the tumor consisted of nests of medium to large cells with little intervening stroma. The tumor invaded a large portal vein branch. All four excised lymph nodes were positive for metastasis, and metastatic deposits were also present in the gallbladder wall. The tumor was diffusely positive for synaptophysin and focally positive for chromogranin A. Approximately 70%-80% of the tumor cells were positive for Ki-67, indicating strong proliferative activity. A diagnosis of LCNEC was made. A few bile ducts within and adjacent to the invasive tumor showed dysplasia of the intestinal phenotype and were focally positive for synaptophysin and chromogranin A, suggesting that the dysplastic intestinal-type epithelium played a precursor role in this case. A postoperative computer tomography scan revealed rapid enlargement of the abdominal and retroperitoneal lymph nodes. The patient died 21 d after the operation. NEC of the bile duct is an aggressive neoplasm, and its biological characteristics remain to be better defined. | Eizaburo Sasatomi Michael A Nalesnik J Wallis Marsh | 2013 | World Journal of Gastroenterology2013，19，28： | 4 |
| 2 | Celecoxib-induced cholestatic liver failure requiring orthotopic liver transplantation显示文摘Selective cyclooxygenase-2 (COX-2) inhibitors are widely used due to their efficacy and good safety profile. However, recent case reports have described varying degrees of liver injuries associated with the use of COX-2 inhibitors. We report the case of a patient who developed acute cholestatic hepatitis progressing to hepatic failure requiring liver transplantation, following a 3-d course of celecoxib for treatment of generalized muscle aches and pains. The clinical presentation, the laboratory data, as well as the liver histopathology were supportive of the putative diagnosis of drug induced liver injury. | Ihab I El Hajj Shahid M Malik Hany R Alwakeel Obaid S Shaikh Eizaburo Sasatomi Hossam M Kandil | 2009 | World Journal of Gastroenterology2009，15，31： | 4 |
| 3 | “Plasma Cell Hepatitis” in Liver Allografts: Identification and Characterization of an IgG4‐Rich Cohort显示文摘 | M. Castillo‐Rama M. Sebagh E. Sasatomi P. Randhawa K. Isse A. D. Salgarkar K. Ruppert A. Humar A. J. Demetris | 2013 | American Journal of Transplantation2013，，11： | 2 |
| 4 | Loss of heterogygosity patterns of sclerosing hemangioma of the lung and bronchioloalveolar carcinoma indicate a similar molecular pathogenesis显示文摘 | Dacic S Sasatomi E Swalsky PA | 2004 | Arch Pathol Lab Med2004，128，8： | 1 |
| 5 | Molecular pathogenesis of pulmonary carcinosarcoma as determined by microdissection-based allelotyping显示文摘 | Dacic S Finkelstein S D Sasatomi E | 2002 | Am J Surg Pathol2002，26，4： | 1 |
| 6 | Expression of c-met in laryngeal carcinoma显示文摘 | Sawatsubashi M Sasatomi E Mizokami H | | 0，，04： | 1 |
| 7 | Biliary secretion of endotoxin and pathogenesis of primary biliary cirrhosis显示文摘 | Sakisaka S Koga H Sasatomi K | 1997 | Yale J Biol Med1997，70，： | 1 |
| 8 | Protein expression and gene amplification of epidermal growth factor receptor in thymomas 显示文摘 | Ionescu D N Sasatomi E Cieply K | 2005 | Cancer2005，103，3： | 1 |
| 9 | GABA receptor activa-tion in the lumbosacral spinal cord decreases detrusor overactivity inspinal cord injured rats显示文摘 | Miyazato M Sasatomi K Hiragata S | 2008 | J Urol2008，179，3： | 1 |
| 10 | Protein expression andgene amplification of epidermal growth factor receptor in thymomas显示文摘 | Ionescu DN Sasatomi E Cieply K | 2005 | Cancer2005，103，3： | 1 |
| 11 | Pulmonary meningothelial-like nodules: a genotypic comparison with meningiomas显示文摘 | IONESCU DN SASATOMI E ALDEEB D | 2004 | Am J Surg Pathol2004，28，2： | 1 |
| 12 | Expression of the hepatocyte growth factor/c-Met pathway is increased at the cancer front in breast carcinoma显示文摘 | Edakuni G Sasatomi E Satoh T | 2001 | Pathol Int2001，51，3： | 1 |
| 13 | Molecularas determined by microdissection-based allelotyping 显示文摘 | Dacic S Finkelstein S D pathogenesis of pulmonary Sasatomi E | 2002 | Am J Surg Pathol2002，26，4： | 1 |
| 14 | Abnormal accumulation of endotoxin in biliary epithelial cells in primary biliary cirrhosis and primary sclerosing cholangitis显示文摘 | Sasatomi K Noguchi K Sakisaka S | 1998 | J Hepatol1998，29，3： | 1 |
| 15 | Compari-son of accumulated allele loss between primary tumor and lymphnodemeta stasis in stage 1 non-small ceil lung carcinoma: implica-tions for the timing of lymph node metastasis and prognostic value显示文摘 | Sasatomie Finkelstein S D Woods JD | 2002 | Cancer Res2002，62，9： | 1 |
| 16 | Protein expression and gene amplification of epidermal growth factor receptor in thymomas显示文摘 | Ionescu DN Sasatomi E Cieply K | 2005 | Cancer2005，103，3： | 1 |
| 17 | Compari- son of accumulated allele loss between primary tumor and lymph node metastasis in stage II non-small cell lung carcinoma: implications for the timing of lymph node metastasis and prognostic value显示文摘 | Sasatomi E Finkelstein SD Woods JD | 2002 | Cancer Res2002，62，9： | 1 |
| 18 | Ursodeoxycholic acid re- duces expression of heat shock proteins in primary biliary cir- rhosis显示文摘 | Sakisaka S Koga H Sasatomi K | 2000 | Liver2000，20，1： | 1 |
| 19 | High prevalence of anticardiolipin antibodies in hepatitis C virus infection: lack of effects on thrombocytopenia and thrombotic complications显示文摘 | Masaru Harada Yuko Fujisawa Shotaro Sakisaka Takumi Kawaguchi Eitaro Taniguchi Masaharu Sakamoto Shuji Sumie Kurumi Sasatomi Hironori Koga Takuji Torimura Takato Ueno Kazuhisa Gondo Hiroshi Yoshida Kyuichi Tanikawa Michio Sata | 2000 | Journal of Gastroenterology2000，，4： | 1 |
| 20 | Recognition of the Lck tyrosine kinase as a tumor antigen by cytotoxic T lymphocytes of cancer patients with distant metastases 显示文摘 | Harashima N Tanaka K Sasatomi T | 2001 | Eur J Immunol2001，31，2： | 1 |
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