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| 1 | Curcumin reverses T cell-mediated adaptive immune dysfunctions in tumor-bearing hosts显示文摘Immune dysfunction is well documented during tumor progression and likely contributes to tumor immune evasion.CD81 cytotoxic T lymphocytes(CTLs)are involved in antigen-specific tumor destruction and CD41 T cells are essential for helping this CD81 T cell-dependent tumor eradication.Tumors often target and inhibit T-cell function to escape from immune surveillance.This dysfunction includes loss of effector and memory T cells,bias towards type 2 cytokines and expansion of T regulatory(Treg)cells.Curcumin has previously been shown to have antitumor activity and some research has addressed the immunoprotective potential of this plant-derived polyphenol in tumor-bearing hosts.Here we examined the role of curcumin in the prevention of tumor-induced dysfunction of T cell-based immune responses.We observed severe loss of both effector and memory T-cell populations,downregulation of type 1 and upregulation of type 2 immune responses and decreased proliferation of effector T cells in the presence of tumors.Curcumin,in turn,prevented this loss of T cells,expanded central memory T cell(TCM)/effector memory T cell(TEM)populations,reversed the type 2 immune bias and attenuated the tumor-induced inhibition of T-cell proliferation in tumor-bearing hosts.Further investigation revealed that tumor burden upregulated Treg cell populations and stimulated the production of the immunosuppressive cytokines transforming growth factor(TGF)-b and IL-10 in these cells.Curcumin,however,inhibited the suppressive activity of Treg cells by downregulating the production of TGF-b and IL-10 in these cells.More importantly,curcumin treatment enhanced the ability of effector T cells to kill cancer cells.Overall,our observations suggest that the unique properties of curcumin may be exploited for successful attenuation of tumor-induced suppression of cell-mediated immune responses. | Sankar Bhattacharyya Dewan Md Sakib Hossain Suchismita Mohanty Gouri Sankar Sen Sreya Chattopadhyay Shuvomoy Banerjee Juni Chakraborty Kaushik Das Diptendra Sarkar Tanya Das Gaurisankar Sa | 2010 | Cellular & Molecular Immunology2010，7，4： | 7 |
| 2 | Deletion of the mouse SlC30A8 gene encoding zinc transporter-8 results in impaired insulin secretion 显示文摘 | Pound LD Sarkar SA Benninger RK | 2009 | Biochem J2009，421，3： | 1 |
| 3 | Matrix metalloproteinases in vascular physiology and disease显示文摘 | Siefert SA Sarkar R | 2012 | Vascular2012，20，4： | 1 |
| 4 | All-trans retinoic acid mediated modulation of p53 during neural differentiation in murine embryonic stem cells显示文摘 | Sarkar SA Sharma RP | 2002 | Cell Biol Toxicol2002，18，4： | 1 |
| 5 | Genistein elicits pleiotropiemolecular effects on head and neck cancer cells 显示文摘 | Alhasan SA Ensley JF Sarkar FH | 2001 | Clin Cancer Res2001，7，12： | 1 |
| 6 | Cytokine-mediated induction of anti-apoptotic genes that are linked to nuclear factor kappa-B(NF-kappaB) signalling in human islets and in a mouse beta cell line 显示文摘 | Sarkar SA Kutlu B Velmurugan K | 2009 | Diabetologia2009，52，6： | 1 |
| 7 | Deletion of the mouse Slc30a8 gene encoding zinc transporter- 8 results in impaired insulin secretion显示文摘 | Pound LD Sarkar SA Benninger RK Et al | 2009 | Biochem J2009，421，3： | 1 |
| 8 | Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion显示文摘 | Pound LD Sarkar SA Benninger RKP | | 0，，05： | 1 |
| 9 | Induction of indoleamine 2,3-dioxygenase by interferon-gamma in human islets显示文摘 | Sarkar SA Wong R Hackl SI | 2007 | Diabetes2007，56，1： | 1 |
| 10 | Matrix metalloproteinases in vascu- lar physiology and disease 显示文摘 | Siefert SA Sarkar R | 2012 | Vascular2012，20，4： | 1 |
| 11 | Matrix metalloproteinases in vascular physiology and disease显示文摘 | Siefert SA Sarkar R | 2012 | Vascular2012，20，4： | 1 |
| 12 | SlC30A8 is a major target of humoral autoimmunity in type 1 diabetes and a predictive marker in prediabetes显示文摘 | Wenzlau JM Moua O Sarkar SA | | 0，，： | 1 |
| 13 | Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion显示文摘 | Pound LD Sarkar SA Benn inger RK | 2009 | Biochem J2009，421，3： | 1 |
| 14 | Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion显示文摘 | Pound LD Sarkar SA Benninger RK | | 0，，03： | 1 |
| 15 | Genistein induced molecular changes in a squamous cell carcinoma of the head and neck cell line显示文摘 | Alhasan SA Ensley JF Sarkar FH | 2000 | Int J Oncol2000，16，2： | 1 |
| 16 | DNA microarray analysis for the identification of innate immune pathways implicated in virus-induced autoimmune diabetes显示文摘 | Wolter TR Wong R Sarkar SA | 2009 | Clin Imunol2009，132，1： | 1 |
| 17 | Cytokine-mediated induction of anti-apoptotic genes that are linked to nuclear factor kappa-B (NF-KB) signalling in human islets and in a mouse beta cell line显示文摘 | Sarkar SA Kutlu B Velmurugan K | 2009 | Diabetologia2009，52，6： | 1 |
| 18 | Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insu- lin secretion 显示文摘 | Pound LD Sarkar SA Benninger RK | 2009 | Biochem J2009，421，3： | 1 |
| 19 | Modulation of c-myc,max,and mad gene expression during neural differentiation of embryonic stem cells by all-trans-retinoic acid显示文摘 | Sarkar SA Sharma RP | 2002 | Gene Expr2002，10，3： | 1 |
| 20 | SIC30A8 is a major target of humoral autoimmunity in type 1 diabetes and a predictive marker in prediabetes显示文摘 | Wenzlau JM Moua O Sarkar SA | 2008 | Ann N Y Acad Sci2008，1150，： | 1 |
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