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您的检索式：作者名="Sarah Pesce"
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| 1 | Role of Macrophage Targeting in the Antitumor Activity of Trabectedin显示文摘 | Giovanni Germano Roberta Frapolli Cristina Belgiovine Achille Anselmo Samantha Pesce Manuela Liguori Eugenio Erba Sarah Uboldi Massimo Zucchetti Fabio Pasqualini Manuela Nebuloni Nico van Rooijen Roberta Mortarini Luca Beltrame Sergio Marchini Ilaria Fuso | 2013 | Cancer Cell2013，，2： | 1 |
| 2 | Role of Macrophage Targeting in the Antitumor Activity of Trabectedin显示文摘 | Giovanni Germano Roberta Frapolli Cristina Belgiovine Achille Anselmo Samantha Pesce Manuela Liguori Eugenio Erba Sarah Uboldi Massimo Zucchetti Fabio Pasqualini Manuela Nebuloni Nico van Rooijen Roberta Mortarini Luca Beltrame Sergio Marchini Ilaria Fuso | 2013 | Cancer Cell2013，，2： | 1 |
| 3 | Improved gastrointestinal health for irritable bowel syndrome with metagenome-guided interventions显示文摘Irritable bowel syndrome(IBS)is the most prevalent functional gastrointestinal disorder worldwide,and the most common reason for referral to gastroenterology clinics.However,the pathophysiology is still not fully understood and consequently current management guidelines are very symptom-specific,leading to mixed results.Here we present a study of 88 individuals with IBS who had baseline sequencing of their gut microbiome(stool samples),received targeted interventions that included dietary,supplement,prebiotic/probiotic,and lifestyle recommendations for a 30-day period,and a follow-up sequencing of their gut microbiome.The study’s objectives were to demonstrate unique metagenomic signatures across the IBS phenotypes and to validate whether metagenomic-guided interventions could lead to improvement of symptom scores in individuals with IBS.Enrolled subjects also completed a baseline and post-intervention questionnaire that assessed their symptom scores.The average symptom score of an individual with IBS at baseline was 160 and at the endpoint of the study the average symptom score of the cohort was 100.9.The mixed IBS subtype showed the most significant reduction in symptom scores across the different subtypes(average decrease by 102 points,P=0.005).The metagenomics analysis reveals shifts in the microbiome post-intervention that have been cross-validated with the literature as being associated with improvement of IBS symptoms.Given the complex nature of IBS,further studies with larger sample sizes,more targeted analyses,and a broader population cohort are needed to explore these results further. | Cem Meydan Ebrahim Afshinnekoo Nate Rickard Guy Daniels Laura Kunces Theresa Hardy Loukia Lili Sarah Pesce Paul Jacobson Christopher E.Mason Joel Dudley Bodi Zhang | 2020 | Precision Clinical Medicine2020，3，2： | 0 |
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