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| 1 | Novel targeting approaches and signaling pathways of colorectal cancer: An insight显示文摘Colorectal cancer(CRC) is the third most common cancer of mortality in the world. Chemotherapy based treatment leads to innumerable side effects as it delivers the anticancer drug to both normal cells besides cancer cells. Sonic Hedgehog(SHH), Wnt wingless-type mouse mammary tumor virus/β-catenin, transforming growth factor-β/SMAD, epidermal growth factor receptor and Notch are the main signaling pathways involved in the progression of CRC. Targeted therapies necessitate information regarding the particular aberrant pathways. Advancements in gene therapies have resulted in the recognition of novel therapeutic targets related with these signal-transduction cascades. CRC is a stepwise process where mutations occur over the time and activation of oncogenes and deactivation of tissue suppressor genes takes place. Genetic changes which are responsible for the induction of carcinogenesis include loss of heterozygosity in tumor suppressor genes such as adenomatous polyposis coli, mutation or deletion of genes like p53 and K-ras. Therefore, many gene-therapy approaches like gene correction, virusdirected enzyme-prodrug therapy, immunogenetic manipulation and virotherapy are currently being explored. Development of novel strategies for the safe and effective delivery of drugs to the cancerous site is the need of the hour. This editorial accentuates different novel strategies with emphasis on gene therapy and immunotherapy for the management of CRC. | Ankita Tiwari Shivani Saraf Amit Verma Pritish Kumar Panda Sanjay K Jain | 2018 | World Journal of Gastroenterology2018，24，39： | 6 |
| 2 | Comparative study of Eu^(3+)-activated LnOCl(Ln=La and Gd) phosphors and their Judd-Ofelt analysis显示文摘Eu3+-activated layered Ln OCl(Ln=La and Gd) phosphors were synthesized by the conventional solid-state method at relatively low temperature(700 °C) and shorter duration of 2 h. The structural parameters were refined by the Rietveld refinement analysis and confirmed by the high resolution transmission electron microscopy(HRTEM). Both the compounds were crystallized in the tetragonal structure with space group P4/nmm(No. 129). The homogeneity of the elements were analyzed by TEM mapping and found to be uniformly distributed. The photoluminescence spectra revealed that the intensity of 5D0→7F2 transition(619 nm) was more intense in Eu3+-activated Gd OCl compared to La OCl. This was due to the property of Gd3+ ions to act as an intermediate sublattice to facilitate the energy transfer to Eu3+ ions. Intensity parameters and radiative properties such as transition probabilities, radiative lifetime and branching ratio were calculated using the Judd-Ofelt theory. The CIE color coordinates result revealed that the Eu3+-activated Gd OCl(0.641, 0.354) phosphor was close to the commercial red phosphors like, Y2O3:Eu3+(0.645, 0.347), Y2O2S:Eu3+(0.647, 0.343) and National Television System Committee(NTSC)(0.67, 0.33). The results suggest that the present Gd OCl:Eu3+ compound acts as a potential candidate for red phosphor materials. | N.Dhananjaya C.Shivakumara Rohit Saraf Sukanti Behera H.Nagabhushana | 2015 | Journal of Rare Earths2015，33，9： | 3 |
| 3 | Consensus statement on the epidemiology,diagnosis,prevention,and management of cow's milk protein allergy in the Middle East:a modified Delphi-based study显示文摘Background This study aimed to develop an expert consensus regarding the epidemiology,diagnosis,and management of cow’s milk protein allergy(CMPA)in the Middle East.Methods A three-step modified Delphi method was utilized to develop the consensus.Fifteen specialized pediatricians participated in the development of this consensus.Each statement was considered a consensus if it achieved an agreement level of>80%.Results The experts agreed that the double-blind placebo-controlled oral challenge test(OCT)should be performed for 2-A weeks using an amino acid formula(AAF)in formula-fed infants or children with suspected CMPA.Formula-fed infants with confirmed CMPA should be offered a therapeutic formula.The panel stated that an extensively hydrolyzed formula(eHF)is indicated in the absence of red flag signs.At the same time,the AAF is offered for infants with red flag signs,such as severe anaphylactic reactions.The panel agreed that infants on an eHF with resolved symptoms within 2-4 weeks should continue the eHF with particular attention to the growth and nutritional status.On the other hand,an AAF should be considered for infants with persistent symptoms;the AAF should be continued if the symptoms resolve within 2-4 weeks,with particular attention to the growth and nutritional status.In cases with no symptomatic improvements after the introduction of an AAF.other measures should be followed.The panel developed a management algorithm,which achieved an agreement level of 90.9%.Conclusion This consensus document combined the best available evidence and clinical experience to optimize the management of CMPA in the Middle East. | Moustafa A.El-Hodhod Mortada H.F.El-Shabrawi Ahmed AIBadi Ahmed Hussein AM Almehaidib Basil Nasrallah Ebtsam Mohammed AIBassam Hala El Feghali Hasan M.Isa Khaled Al Saraf Maroun Sokhn Mehdi Adeli Najwa Mohammed Mousa Al-Sawi Pierre Hage Suleiman Al-Hammadi | 2021 | World Journal of Pediatrics2021，17，6： | 3 |
| 4 | Application of Statistically Based Experimental Designs to Optimize Cellulase Production and Identification of Gene显示文摘A natural bacterial strain identified as Bacillus amyloliquefaciens MBAA3 using 16S rDNA partial genome sequencing has been studied for optimization of cellulase production.Statistical screening of media components for production of cellulase by B.amyloliquefaciens MBAA3 was carried out by Plackett–Burman design.Plackett–Burman design showed CMC,MgSO4 and pH as significant components influencing the cellulase production from the media components screened by Plackett-Burman fractional factorial design.The optimum concentrations of these significant parameters were determined employing the response surface central composite design,involving three factors and five levels was adopted to acquire the best medium for the production of cellulase enzyme revealed concentration of CMC(1.84 g),MgSO4(0.275 g),and pH(8.5)in media for highest enzyme production.Response surface counter plots revealed that middle level of MgSO4 and middle level of CMC,higher level of CMC and lower level of pH and higher level of MgSO4 with lower level of pH increase the production of cellulase.After optimization cellulase activity increased by 6.81 fold.Presence of cellulase gene in MBAA3 was conformed by the amplification of genomic DNA of MBAA3.A PCR product of cellulase gene of 1500 bp was successfully amplified.The amplified gene was conformed by sequencing the amplified product and sequence was deposited in the gene bank under the accession number KF929416. | Aarti Thakkar Meenu Saraf | 2014 | Natural Products and Bioprospecting2014，4，6： | 3 |
| 5 | Nose-to-brain drug delivery approach:a key to easily accessing the brain for the treatment of Alzheimer's disease显示文摘Alzheimer’s disease(AD):AD,a neurodegenerative disorder and a significant cause of dementia throughout the world mostly affects the older adults but sometimes also seen in young age(early state AD)(Agrawal et al.,2017).As per the Alzheimer Asstohciation report 2017,AD remains | Amit AlexANDer Shailendra Saraf | 2018 | Neural Regeneration Research2018，13，12： | 2 |
| 6 | Comparison of different models for susceptibility mapping of earthquake triggered landslides related with the 2008 Wenchuan earthquake in China显示文摘 | Chong Xu Xiwei Xu Fuchu Dai Arun K. Saraf | 2012 | Computers and Geosciences2012，，： | 2 |
| 7 | The Integrator complex controls the termination of transcription at diverse classes of gene targets显示文摘包含 INTS3 和 NABP1 或 NABP2 的建筑群开始在 DNA 损坏回答被描绘,但是他们的生物化学的功能仍然保持未知。用亲密关系纯化和 HIV 集成定序目标(HIT-Seq ) ,我们发现这些建筑群是综合者建筑群的部分,它绑 RNA 聚合酶 II 并且调整特定的目标基因。综合者作为他们在亲密地被结合的机制处理到他们的成熟形式的部分劈开 snRNAs 抄写结束。然而, HIT-Seq 表明那个综合者也绑在 3 ′以 polyadenylated 抄本复制依赖者 histones 和倡导者结束基因的近似区域。综合者子单元的弄空导致抄写结束失败, histone mRNA 处理的混乱,和 snRNAs 和 histone mRNAs 的 polyadenylation。而且,倡导者综合者的近似绑定否定地通常调整其抄本是的基因的表示 polyadenylated。到所有三个基因类的综合者招募是 DSIF 依赖的,建议那个综合者作为在 DSIF 依赖的 RNA 聚合酶 II 的结束建筑群工作暂停地点。 | Jeffrey R Skaar Andrea L Ferris Xiaolin Wu Anita Saraf Kum Kum Khanna Laurence Florens Michael P Washburn Stephen H Hughes Michele Pagano | 2015 | Cell Research2015，25，3： | 2 |
| 8 | Effect of simvastatin on fracture healing an experimental study 显示文摘 | Saraf S K Singh A Garbyal R S | 2007 | Indian J Exp Bio12007，45，5： | 1 |
| 9 | Assimilation of enterprise systems : The effect of institutional pressures and the mediating role of top management显示文摘 | Liang H G Saraf N Hu Q | 2007 | MIS Quarterly2007，31，1： | 1 |
| 10 | A direct correlation function for mesomorphic polymers and its application to the 'smectic' phase of isotactic polpropylene 显示文摘 | Cohen Y Saraf R F | 2001 | Polymer2001，42，： | 1 |
| 11 | Morphology of PbI2crystals grown by gel method显示文摘 | BHAVSAR D S SARAF K B | 2002 | Cryst Res Technol2002，37，1： | 1 |
| 12 | Design and E- valuation of an Acceleration Guidance Algorithm for En- try显示文摘 | Saraf A Leavitt J A Chen D T | 2004 | Journal of Spaceeraft and Rocket2004，41，6： | 1 |
| 13 | Satellite Detection of Earthquake Thermal Infrared Precursors in Iran显示文摘 | Saraf A k Rawat P | 2008 | Nature Hazard2008，47，： | 1 |
| 14 | IS application capabilities and relational value in interrm partnerships显示文摘 | SARAF N LANGDON C S GOSAIN S | 2007 | Information Systems Research2007，18，3： | 1 |
| 15 | 4-Thiazolidinone:a biologically active scaffold显示文摘 | Verma A Saraf K S | 2008 | European Journal of Medicinal Chemistry2008，43，5： | 1 |
| 16 | Use of gas chromatography - ion trap tandem mass spectrometry for the detection and characterization of microorganism in complex samples显示文摘 | Larson L Saraf A | 1997 | Molecular Biotechnology1997，7，3： | 1 |
| 17 | Cubosomes: an overview 显示文摘 | Garg G Saraf S Saraf S | 2007 | Biol Pharm Bu112007，30，2： | 1 |
| 18 | Ceria incorporation into YSZ columnar nanostruc- lures 显示文摘 | SARAF L MATSON D W SHUTFHANANI)AN V | 2005 | Electrochemical and Solid-Stale Letters2005，8，10： | 1 |
| 19 | False topography perception phenomena and its correction 显示文摘 | Saraf A K Das J D Agarwal B | 1996 | International Journal of Remote Sensing1996，17，18： | 1 |
| 20 | Gene delivery strategies for cartilage tissue engi- neering显示文摘 | Saraf A Mikos AG | 2006 | Adv Drug Deliv Rev2006，4，： | 1 |
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