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| 1 | How important is donor age in liver transplantation?显示文摘The age of liver donors has been increasing in the past several years because of a donor shortage. In the United States, 33% of donors are age 50 years or older, as are more than 50% in some European countries. The impact of donor age on liver transplantation(LT) has been analyzed in several studies with contradictory conclusions. Nevertheless, recent analyses of the largest databases demonstrate that having an older donor is a risk factor for graft failure. Donor age is included as a risk factor in the more relevant graft survival scores, such as the Donor Risk Index, donor age and Model for End-stage Liver Disease, Survival Outcomes Following Liver Transplantation, and the Balance of Risk. The use of old donors is related to an increased rate of biliary complications and hepatitis C virus-related graft failure. Although liver function does not seem to be significantly affected by age, the incidence of several liver diseases increases with age, and the capacity of the liver to manage or overcome liver diseases or external injuries decreases. In this paper, the importance of age in LT outcomes, the role of donor age as a risk factor, and the influence of aging on liver regeneration are reviewed. | Alberto Lué Estela Solanas Pedro Baptista Sara Lorente Juan J Araiz Agustin Garcia-Gil M Trinidad Serrano | 2016 | World Journal of Gastroenterology2016，22，21： | 10 |
| 2 | 全球气候变化对北极海洋生态系统持久性有机污染物和汞途径及暴露的生态影响研究显示文摘生物累积性和生物放大污染物,如持久性有机污染物(POPs)和汞(Hg),数十年来一直被公认为在北极海洋生物健康的关注。近年来,全球气候变化(GCC)和北极海冰相关损失已观察到驱动大幅改变北极生态系统。本文综述了研究记录的经验之间的联系GCC诱导的流行和在北极海洋生态系统的汞暴露和通路的生态变化和改变。大多数的研究报道在流行或汞浓度变化与GCC引起的物种营养相互作用的变化组织。这些研究通常集中在阿舞的角色变化,栖息地的范围或接近猎物,尤其是在与海冰变化。然而,生态变化,重新适应污染物的趋势变化往往是不清楚或假定。其他的研究已经成功地使用化学示踪剂,如稳定的氮和碳同位素比值和脂肪酸签名连接这样的生态变化,污染物水平的变化或趋势。较低的海冰与饮食变化/变异与较高的污染水平在一些不同的北极熊,以及相关的环斑海豹,和厚嘴默,但改变营养相互作用影响的流行水平和趋势的大小和方向的变化很大。我们建议在这一新领域的GCC链接ECOTOX -生态学的重点应该放在配套的生态指标与流行和汞的研究常规分析未来的研究,同时考虑了GCC和污染物的相互作用可能发生的多种机制,并有针对性地研究变化的暴露和毒性的物种称为敏感的GCC和污染物[现行生态61(4):617-628,2015 ]。 | Melissa A. MCKINNEY Sara PEDRO Rune DIETZ Christian SONNE Aaron T. FISK Denis ROY Bjorn M. JENSSEN Robert J. LETCHER | 2015 | Current Zoology2015，61，4： | 7 |
| 3 | Essential role of small bowel capsule endoscopy in reclassification of colonic inflammatory bowel disease type unclassified显示文摘AIM To evaluate the role of small bowel capsule endoscopy(SBCE) on the reclassification of colonic inflammatory bowel disease type unclassified(IBDU).METHODS We performed a multicenter, retrospective study including patients with IBDU undergoing SBCE, between 2002 and 2014. SBCE studies were reviewed and the inflammatory activity was evaluated by determining the Lewis score(LS). Inflammatory activity was considered significant and consistent with Crohn's disease(CD) when the LS ≥ 135. The definitive diagnosis during follow-up(minimum 12 mo following SBCE) was based on the combination of clinical, analytical, imaging, endoscopic and histological elements.RESULTS Thirty-six patients were included, 21 females(58%) with mean age at diagnosis of 33 ± 13(15-64) years. The mean follow-up time after the SBCE was 52 ± 41(12-156) mo. The SBCE revealed findings consistent with significant inflammatory activity in the small bowel(LS ≥ 135) in 9 patients(25%); in all of them the diagnosis of CD was confirmed during follow-up. In 27 patients(75%), the SBCE revealed no significant inflammatory activity(LS < 135); among these patients, the diagnosis of Ulcerative Colitis(UC) was established in 16 cases(59.3%), CD in 1 case(3.7%) and 10 patients(37%) maintained a diagnosis of IBDU during follow-up. A LS ≥ 135 at SBCE had a sensitivity = 90%, specificity = 100%, positive predictive value = 100% and negative predictive value = 94% for the diagnosis of CD.CONCLUSION SBCE proved to be fundamental in the reclassification of patients with IBDU. Absence of significant inflammatory activity in the small intestine allowed exclusion of CD in 94% of cases. | Sara Monteiro Francisca Dias de Castro Pedro Boal Carvalho Bruno Rosa Maria Joao Moreira Rolando Pinho Miguel Mascarenhas Saraiva José Cotter | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，1： | 3 |
| 4 | PillCam~ SB3 capsule: Does the increased frame rate eliminate the risk of missing lesions?显示文摘Since its emergence in 2000, small bowel capsule endoscopy(SBCE) has assumed a pivotal role as an investigation method for small bowel diseases. The PillCam SB2-ex offers 12 h of battery time, 4 more than the previous version(SB2). Rahman et al recently found that the PillCam SB2-ex has a significantly increased completion rate, although without higher diagnostic yield, compared with the SB2. We would like to discuss these somewhat surprising results and the new potentialities of the PillCam SB3 regarding the diagnostic yield of small bowel studies. PillCam SB3 offers improved image resolution and faster adaptable frame rate over previous versions of SBCE. We recently compared the major duodenal papilla detection rate obtained with PillCam SB3 and SB2 as a surrogate indicator of diagnostic yield in the proximal small bowel. The PillCam SB3 had a significantly higher major duodenal papilla detection rate than the PillCam SB2(42.7% vs 24%, P = 0.015). Thus, the most recent version of the PillCam capsule, SB3, may increase diagnostic yield, particularly in the proximal segments of the small bowel. | Sara Monteiro Francisca Dias de Castro Pedro Boal Carvalho Maria Joao Moreira Bruno Rosa José Cotter | 2016 | World Journal of Gastroenterology2016，22，10： | 2 |
| 5 | Capsule endoscopy capture rate: Has 4 frames-per-second any impact over 2frames-per-second?显示文摘AIM: To compare the current capsule and a new prototype at 2 and 4 frames-per-second, respectively, in terms of clinical and therapeutic impact. METHODS: One hundred patients with an indication for capsule endoscopy were included in the study. All procedures were performed with the new device(SB24). After an exhaustive evaluation of the SB24 videos, they were then converted to 'SB2-like' videos for their evaluation. Findings, frames per finding, and clinical and therapeutic impact derived from video visualization were analyzed. Kappa index for interobserver agreement and χ2 and Student's t tests for qualitative/quantitative variables, respectively, were used. Values of P under 0.05 were considered statistically significant.RESULTS: Eighty-nine out of 100 cases included in the study were ultimately included in the analysis. The SB24 videos detected the anatomical landmarks(Zline and duodenal papilla) and lesions in more patients than the 'SB2-like' videos. On the other hand, the SB24 videos detected more frames per landmark/lesion than the 'SB2-like' videos. However, these differences were not statistically significant(P > 0.05). Both clinical and therapeutic impacts were similar between SB24 and 'SB2-like' videos(K = 0.954). The time spent by readers was significantly higher for SB24 videos visualization(P < 0.05) than for 'SB2-like' videos when all images captured by the capsule were considered. However, these differences become non-significant if we only take into account small bowel images(P > 0.05).CONCLUSION: More frames-per-second detect more landmarks, lesions, and frames per landmark/lesion, but is time consuming and has a very low impact on clinical and therapeutic management. | Ignacio Fernandez-Urien Cristina Carretero Erika Borobio Ana Borda Emilio Estevez Sara Galter Begoa Gonzalez-Suarez Benito Gonzalez Marisol Lujan Jose Luis Martinez Vanessa Martínez Pedro Menchén Javier Navajas Vicente Pons Cesar Prieto Julio Valle | 2014 | World Journal of Gastroenterology2014，20，39： | 2 |
| 6 | Impact of coronary angioplasty in elderly patients with non-ST-segment elevation myocardial infarction显示文摘Background As treatment of coronary artery disease improved over the last years,management of elder patients remained a matter of debate since this age group has been underrepresented in most trials.The study aimed to evaluate a population of patients with≥85 years old with non-ST-segment elevation myocardial infarction(NSTEMI)and compare the prognosis according to coronary revascularization execution.Methods We retrospectively studied 324 patients included in a national multicenter registry between October 2010 and October 2018,who underwent coronary angiography and had at least one stenosis≥50%.Results In this population,73.1%of the patients underwent percutaneous coronary intervention(PCI)and 26.9%of the patients underwent optimized medical treatment(OMT).The OMT group had more past history of diabetes,stroke and dementia.On coronary angiography,the PCI group used more often the femoral artery access and single-vessel lesions were also more common.Three-vessel disease was more common in the OMT group.During hospitalization,there were more major bleeding events and death in the PCI group.During the one-year follow-up,there were no significant differences in all-cause mortality rate.Conclusions Very old patients with NSTEMI submitted to OMT had more comorbidities and more three-vessel disease,factors that could have influenced the therapeutic decision.Patients undergoing PCI had more in-hospital major bleeding events and mortality,with no significant differences after one year. | Fernando F.Goncalves José P.Guimaraes Sara C.Borges Pedro S.Mateus José I.Moreira | 2020 | Journal of Geriatric Cardiology2020，17，8： | 2 |
| 7 | Cloud computing in industrial SMEs-identification of the barriers to its adoption and effects of its application显示文摘 | Sara T Deniel P Pedro S | 2013 | Electronic Markets2013，23，2： | 1 |
| 8 | Esophageal stenosis with sloughing esophagitis:A curious manifestation of graft-vs-host disease显示文摘We report a case of a 56-year-old woman with a history of allogenic bone marrow transplantation for two years,complaining with dysphagia and weight loss. Upper endoscopy revealed esophageal stenosis and extensive mucosa sloughing. Biopsies confirmed the diagnosis of graft-vs-host disease(GVHD). Balloon dilation,corticosteroids and cyclosporin resulted in marked clinical improvement. Gastrointestinal tract is involved in the majority of patients with chronic GVHD. Esophageal manifestations are rare and include vesiculobullous disease,ulceration,esophageal webs,casts or strictures. Sloughing esophagitis along with severe stenosis requiring endoscopic dilation has never been reported in this context. | Daniel Trabulo Sara Ferreira Pedro Lage Rafaela Lima Rego Gilda Teixeira A Dias Pereira | 2015 | World Journal of Gastroenterology2015，21，30： | 1 |
| 9 | modified atmospheres to prolong the postharvest life of Burlat cherries at two different degrees of ripeness 显示文摘 | Sara Remon Ana Fcrrer Pedro Marquina | 2000 | Journal of the Science of Food and Agriculture2000，80，： | 1 |
| 10 | Development of a methodology for automated crater detection on planetary images 显示文摘 | LOUREN B SARA J PEDRO P | 2009 | Lecture Notes in Computer Science2009，4447，： | 1 |
| 11 | Singular quasilinear equations with quadratic growth in the gradi- ent without sign condition显示文摘 | ARCOYA David BARILE Sara Martinez-aparicio Pedro J | 2009 | Journal of Mathematical Analysis and Applications2009，350，： | 1 |
| 12 | Advanced acoustic wake-up system for underwater sensor networks显示文摘 | Antonio Sanchez Sara Blanc Pedro Yuste | 2012 | Communications in Information Science and Management Engineering2012，2，2： | 1 |
| 13 | Oral intake throughout the patients’ lives after palliative metallic stent placement for malignant gastroduodenal obstruction: a retrospective multicentre study显示文摘 | Jorge M. Canena Ana C. Lagos Inês N. Marques Sara D. Patrocínio Miguel G. Tomé Manuel A. Liberato Carlos M. Rom?o António P. Coutinho Pedro M. Veiga Beatriz C. Neves Hélder D. Além José A. Gon?alves | 2012 | European Journal of Gastroenterology & Hepatology2012，，7： | 1 |
| 14 | The inhibitory effect of Plectranthus barbatus and Plec- tranthus ecklonii leaves on the viability, glucosyl transferase activity and biofilm formation of Strepto- coccus sobrinus and Streptococcus mutans 显示文摘 | Neusal F Sara Raquelm M A Pedro L F | 2010 | Food Chem2010，119，2： | 1 |
| 15 | Nitrogen remote diagnosis in a creeping bentgrass golf green显示文摘 | Rafael J. López-Bellido Luis López-Bellido Purificación Fernández-García Juan M. López-Bellido Verónica Mu?oz-Romero Pedro J. López-Bellido Sara Calvache | 2011 | European Journal of Agronomy2011，，1： | 1 |
| 16 | Extraction/oxidation kinetics of low molecular weight compounds in wine brandy resulting from different ageing technologies显示文摘 | Sara Canas Ilda Caldeira A. Pedro Belchior | 2013 | Food Chemistry2013，，： | 1 |
| 17 | Microstructural characterization and mechanical behavior analysis of 7075-T6 aluminum subjected to simulated lightning strikes显示文摘Aircrafts damages caused by lightning strikes have been known since the early days of aviation.However,the physical effects on the aircraft structure are still being investigated.This work seeks to evaluate the lightning strike effects in the aluminum alloy 7075-T6.Samples were submitted to lightning strike simulation in laboratory and the damages evaluated through characterization techniques.Ultrasound and profilometry tests have shown material loss to 0.272 mm depth in the damaged region.In addition,it was detected the material accumulation occurrence in the damage vicinity of the region.Below the damage,it was found a region where metallurgical changes were identified.The tensile and microhardness tests results have shown reduction in the percentage elongation and hardness increasing in the material affected by lightning.These results are corroborated by the X-Ray Diffraction(XRD)and Rietveld Method(red line)that indicated an increasing in dislocation density and micro-deformation in the material matrix.Optical microscopy results have shown the presence of microcracks on the normal and cross-section surface of the samples damaged.The Energy Dispersive X-Ray Spectroscopy(EDXS)and Electron Backscattered Diffraction Test(EBSD)found coarse intermetallic phases and precipitates compounds with dimensions greater than 1 lm in length.They were responsible for nucleation of the microcracks that propagate along the material grain boundaries. | Luis Henrique SANTOS Weslei Patrick Teodosio SOUSA Sara Silva Ferreira DE DAFE Pedro Americo Magalhaes JUNIOR | 2021 | Chinese Journal of Aeronautics2021，34，12： | 1 |
| 18 | Entwining Psychology and Visual Arts: A Classroom Experience显示文摘 | Sara Bahia Jos6 Pedro Trindade | 2012 | Psychology Research2012，2，2： | 0 |
| 19 | 多功能农用车设计,农业生产中的全能助手显示文摘Harto是一个能应用在农业生产多个环节的多功能车。Harto根据农民在生产环境中的真实需求而设计,各个模块直接对应不同的生产阶段,主要目的是帮助农民在生产中提高效率,减轻身体负担。无人机模块主要为Harto所执行的各种任务提供支持,例如事先绘制路线、绘制操作地图等,确保Harto顺利开展各项工作。此外,无人机可降落在车辆顶部的充电平台上。 | Diogo Lampreia Bernardo Pereira Sara Pedro | 2023 | 工业设计2023，，12： | 0 |
| 20 | Machine learning using the extreme gradient boosting (XGBoost) algorithm predicts 5-day delta of SOFA score at ICU admission in COVID-19 patients显示文摘Background:Accurate risk stratification of critically ill patients with coronavirus disease 2019(COVID-19)is essential for optimizing resource allocation,delivering targeted interventions,and maximizing patient survival probability.Machine learning(ML)techniques are attracting increased interest for the development of prediction models as they excel in the analysis of complex signals in data-rich environments such as critical care.Methods:We retrieved data on patients with COVID-19 admitted to an intensive care unit(ICU)between March and October 2020 from the RIsk Stratification in COVID-19 patients in the Intensive Care Unit(RISC-19-ICU)registry.We applied the Extreme Gradient Boosting(XGBoost)algorithm to the data to predict as a binary out-come the increase or decrease in patients’Sequential Organ Failure Assessment(SOFA)score on day 5 after ICU admission.The model was iteratively cross-validated in different subsets of the study cohort.Results:The final study population consisted of 675 patients.The XGBoost model correctly predicted a decrease in SOFA score in 320/385(83%)critically ill COVID-19 patients,and an increase in the score in 210/290(72%)patients.The area under the mean receiver operating characteristic curve for XGBoost was significantly higher than that for the logistic regression model(0.86 vs.0.69,P<0.01[paired t-test with 95%confidence interval]).Conclusions:The XGBoost model predicted the change in SOFA score in critically ill COVID-19 patients admitted to the ICU and can guide clinical decision support systems(CDSSs)aimed at optimizing available resources. | Jonathan Montomoli Luca Romeo Sara Moccia Michele Bernardini Lucia Migliorelli Daniele Berardini Abele Donati Andrea Carsetti Maria Grazia Bocci Pedro David Wendel Garcia Thierry Fumeaux Philippe Guerci Reto Andreas Schüpbach Can Ince Emanuele Frontoni Matthias Peter Hilty RISC-19-ICU Investigators | 2021 | Journal of Intensive Medicine2021，1，2： | 0 |
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