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| 1 | Timely reperfusion for ST-segment elevation myocardial infarction:Effect of direct transfer to primary angioplasty on time delays and clinical outcomes显示文摘Primary percutaneous coronary intervention(PPCI) is the preferred reperfusion therapy for patients presenting with ST-segment elevation myocardial infarction(STEMI) when it can be performed expeditiously and by experienced operators. In spite of excellent clinical results this technique is associated with longer delays than thrombolysis and this fact may nullify the benefit of selecting this therapeutic option. Several strategies have been proposed to decrease the temporal delays to deliver PPCI. Among them,prehospital diagnosis and direct transfer to the cath lab,by-passing the emergency department of hospitals,has emerged as anattractive way of diminishing delays. The purpose of this review is to address the effect of direct transfer on time delays and clinical events of patients with STEMI treated by PPCI. | Rodrigo Estévez-Loureiro ángela López-Sainz Armo Pérez de Prado Carlos Cuellas Ramón Calvio Santos Norberto Alonso-Orcajo Jorge Salgado Fernández Jose Manuel Vázquez-Rodríguez Maria López-Benito Felipe Fernández-Vázquez | 2014 | World Journal of Cardiology2014,6,6: | 6 |
| 2 | Clinical hematological and biochemical parameters in Swiss,BALB/c,C57BL/6 and B6D2F1 Mus musculus显示文摘Background:Animal models are widely used in scientific research in order to obtain information from a whole organism under a specific set of experimental conditions.Various lineages of mice have been used to investigate diseases and new therapeutic strategies,and,consequently,hematological and biochemical tests in these laboratory animals are essential to validate scientific studies.Our study seeks to establish reference values for hematological and biochemical parameters of four lineages of mice.Methods:We evaluated the hematological and biochemical profiles of 20 males and 20 females from the lineages Swiss(heterogeneous),BALB/c and C57BL/6(isogenic),and B6D2F1(hybrid),totaling 160 mice.Analysis were standardized using the systems pocH-100iV Diff™for 19 hematological parameters and VITROS®350 for 12 biochemical parameters.Results:Results are shown as means and standard deviation,grouped by lineage and genre.Comparing the values obtained in this study with the values from previous studies,some variations were detected,which could be explained by differences in methodologies or individual variability.Conclusion:Thus our study shows that knowledge and disclosure of the values of physiological parameters of laboratory animals is necessary,and emphasises the importance of considering variations influenced by gender,lineage and genotype in the choice of the best experimental model. | Giorgio Silva-Santana Juliet Cunha Bax Débora Cristina Silva Fernandes Daniela Tendler Leibel Bacellar Cleber Hooper Alexandre Alves Souza Oliveira Dias Cristina Barbosa Silva Aline Moreira de Souza Simone Ramos Ricardo Alexandre Santos Thainara Ramos Pinto Mariana Antunes Ramão Ana Luíza Mattos-Guaraldi | 2020 | Animal Models and Experimental Medicine2020,3,4: | 2 |
| 3 | Anti-inflammatory intestinal activity of Arctium lappa L. (Asteraceae) in TNBS colitis model显示文摘 | Ana Beatriz Albino de Almeida Marina Sánchez-Hidalgo Antonio Ramón Martín Anderson Luiz-Ferreira José Roberto Trigo Wagner Vilegas Lourdes Campaner dos Santos Alba Regina Monteiro Souza-Brito Catalina Alarcón de la Lastra | 2013 | Journal of Ethnopharmacology2013,,1: | 1 |
| 4 | Characterization of pulmonary vascular remodelling in smokers and patients with mild COPD显示文摘 | Santos S Peinado VI Ramírez J | | 0,,04: | 1 |
| 5 | Subcritical water and dynamic sonication-assisted solvent extraction of fluorescent whitening agents and azo dyes in paper samples显示文摘 | Mario de los Santos Ramón Batlle Jesús Salafranca Cristina Nerín | 2005 | Journal of Chromatography A2005,,2: | 1 |
| 6 | Olefins production from cracking of a Fischer-Tropsch naphtha 显示文摘 | Fonseca N dos Santos L R M Cerqueira H S Lemos F Ram?a-Ribeiro F Lam Y L de Almeida M B B | 2012 | Fuel2012,95,: | 1 |
| 7 | Aqueous humor and serum tumor necrosis factor-alpha in clinical uveitis显示文摘 | Santos Lacomba M Marcos Martin C Gallardo Galera JM Gómez Vidal MA Collantes Estévez Ramírez Chamond R | 2001 | Ophthalmic Res2001,33,5: | 1 |
| 8 | Micromachined optical fiber current sensor显示文摘 | R L Heredero Ramón Fernández de Caleya héctor Guerrero Pere Los Santos Mari Cruz Jaume Esteve | 1999 | Appl Opt1999,38,25: | 1 |
| 9 | Functional recovery of paraplegic rats and motor axon regeneration in their spinal cords by olfactory ensheathing glia显示文摘 | RAM CUETO A CORDERO MI SANTOS BENITO FF | 2000 | Neuron2000,25,: | 1 |
| 10 | Variability patterns and positively selected sites at the gametophytic self - incompatibility pollen SFB gene in a wild self - in- compatible Pmnus spinosa (Rosaceae) populationl 显示文摘 | Nunes MDS Santos RAM Ferreira SM | 2006 | New Phytol2006,172,: | 1 |
| 11 | Ethylbenzene oxidation with air catalysed by bis(acetylacetonate)nickel(11)and tetra-n-butylammonium tetrafluoroborate显示文摘 | Ramón Alcántara Laureano Canoira Pedro Guilherme Joao José-Ma'1a Santos Ignacio Vázquez | 2000 | Applied Catalysis A:General2000,,203: | 1 |
| 12 | Characterization of pulmonary vascular remodelling in smokers and patients with mild COPD显示文摘 | Santos S Peinado VI Ramírez J | 2002 | European Respiratory Journal2002,19,4: | 1 |
| 13 | A case of hepatopulmonary syndrome solved by mycophenolate mofetil (an inhibitor of angiogenesis and nitric oxide production)显示文摘 | Helena Moreira Silva Guilhermina Reis Margarida Guedes Esmeralda Cleto José Ramón Vizcaíno Deirdre Kelly Andrew R. Gennery Ermelinda Santos Silva | 2012 | Journal of Hepatology2012,,: | 1 |
| 14 | DLST mutations in pheochromocytoma and paraganglioma cause proteome hyposuccinylation andmetabolic remodeling显示文摘Dear Editor,Of all human tumors,pheochromocytomas and paragangliomas(PPGLs)have the highest heritability rate.Over 15%of PPGLs harbor mutations in genes encoding tricarboxylic acid(TCA)cycle-related enzymes that cause oncometabolite accumulation and drive tumorigenesis via metabolic adaptation to hypoxia and global hypermethylation[1].The dihydrolipoamide S-succinyltransferase(DLST)gene was recently described as a new PPGL susceptibility gene[2]. | Sara Mellid Fernando García Luis Javier Leandro-García Alberto Díaz-Talavera Ángel Mario Martínez-Montes Eduardo Gil Bruna Calsina María Monteagudo Rocío Letón Juan María Roldán-Romero María Santos Javier Lanillos Carlos Valdivia Natalia Martínez-Puente Javier de Nicolás-Hernández Scherezade Jiménez Manuel Pérez-Martínez Emiliano Honrado Javier Coloma Ana Cerezo Clara María Santiveri Manel Esteller Ramón Campos-Olivas Eduardo Caleiras Cristina Montero-Conde Cristina Rodríguez-Antona Javier Muñoz Mercedes Robledo Alberto Cascón | 2023 | Cancer Communications2023,43,7: | 0 |