|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 干扰素调节因子5通过损伤胞葬作用控制动脉粥样硬化病变中的坏死核心形成显示文摘髓系细胞是动脉粥样硬化病变发展和易损斑块形成的核心。动脉吞噬细胞吸收凋亡细胞(胞葬作用)的能力受损,可促进病变生长并建立坏死核心。干扰素调节因子(interferon regulatory factor,IRF)5是髓系细胞功能的重要调节因子。该研究试图确定IRF5是否影响动脉粥样硬化病变的形成和表型。方法:通过两种互补模型,研究IRF5在动脉粥样硬化中的作用: | Seneviratne AN Edsfeldt AO Cole JE Kassiteridi C Swart M Park I Green P Khoyratty TE Saliba DG Goddard ME Sansom SN Goncalves I Krams R Udalova IA Monaco C 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，8： | 9 |
| 2 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 3 | Toward proteomics in uroscopy: urinary protein profiles after radiocontrast medium administration 显示文摘 | Sansome C Sha M | 2001 | J Am Soc Nephrol2001，12，5： | 1 |
| 4 | What ' s the difference between CD80 and CD86? 显示文摘 | SANSOM D M MANZOTTI C N ZHENG Y | 2003 | Trends Immunol2003，24，6： | 1 |
| 5 | Up in a cloud? 显示文摘 | Sansom C | 2010 | Nat Biotechnol2010，1，28： | 1 |
| 6 | The lipocalin pro- tein family: structural and sequence overview显示文摘 | FLOWER D R NORTH A C SANSOM C E | 2000 | Biochim Biophys Ac- ta2000，1482，12： | 1 |
| 7 | Open-State Models of a Potassium Channel显示文摘 | BIGGIN P C SANSOM M S P | 2002 | Biophys J2002，83，： | 1 |
| 8 | LPS inhibitors:Key to overcoming multidrug-resistant bacteria显示文摘 | SANSOM C WRITER F | 2001 | Drug Discovery Today2001，，： | 1 |
| 9 | Glonaerular mesangial cells: electro- physiology and regulation of contraction显示文摘 | Stockand J D Sansom S C | 1998 | Physiol Rev1998，78，3： | 1 |
| 10 | Mineralocorticoid,regulation of apical cell membrane Na+ and K+ transport of the cortical collecting duct显示文摘 | SANSOM S C O'NEIL R G | 1985 | American Journal of Physiology1985，248，2： | 1 |
| 11 | Application of high and low frequency scillations to the plastic deformation of metal 显示文摘 | Dnwson G R Winsper C E Sansome D H | 1996 | Metal Forming1996，231，8： | 1 |
| 12 | Towards proteomics in uroseopy:urinary protein profiles after radiocontrast medium administration显示文摘 | Hampel D J Sansome C Sha M | 2001 | J Am Society Nephrol2001，12，： | 1 |
| 13 | Application of high and low frequency scillations to t he plastic deformation of metal 显示文摘 | Dawson G R Winsper C E Sansome D H | 1996 | Metal Forming1996，231，8： | 1 |
| 14 | Updates oflifetime costs of care and quality -of -life estimates forHIV -infected persons in the United States : late versusearly diagnosis and entry into care 显示文摘 | Famham PG Gopalappa C Sansom SL | 2013 | JAIDS Journal ofAcquired Immune Deficiency Syndromes2013，64，2： | 1 |
| 15 | The geology of British oilfields 3: the oilfields of Burma 显示文摘 | Evans P Sansom C A | 1941 | Geological Magazine1941，78，3： | 1 |
| 16 | The lipocalin protein family:structural and sequence overview显示文摘 | FLOWER D R NOAH A C T SANSOM C E | | 0，，： | 1 |
| 17 | Surface binding of alamethicin stabilizes its helical structure: molecular dynamics simulations 显示文摘 | Tieleman D P Berendsen H J C Sansom M S | 1999 | Biophys J1999，76，： | 1 |
| 18 | Evaluation of Support Vector Machine Based Forecasting Tool in Electricity Price Forecasting for Australian National Electricity Market Participants显示文摘 | D C Sansom T Downs T K Saha | 2003 | Journal of Electrical and Electronics Engineering2003，22，3： | 1 |
| 19 | Glomemlar mesangial cells: electrophysiology and regulation of contraction 显示文摘 | STOCKAND J D SANSOM S C | 1998 | Physiol Rev1998，78，： | 1 |
| 20 | The lipocalin protein family- Structural and sequence overview 显示文摘 | Flower D R North A C T Sansom C E | 2000 | Biochim Biophys Acta2000，1482，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员