|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | PPIs are not associated with a lower incidence of portal-hypertension-related bleeding in cirrhosis显示文摘AIM:To determine if proton pump inhibitor use in cirrhotic patients with endoscopic findings of portal hypertension is associated with a lower frequency of gastrointestinal bleeding.METHODS:Patients with cirrhosis and endoscopic findings related to portal hypertension,receiving or not receiving proton pump inhibitor (PPI) therapy,were included retrospectively.We assigned patients to two groups:group 1 patients underwent PPI therapy and group 2 patients did not undergo PPI therapy.RESULTS:One hundred and five patients with a median age of 58 (26-87) years were included,57 (54.3%) of which were women.Esophageal varices were found in 82 (78%) patients,portal hypertensive gastropathy in 72 (68.6%) patients,and gastric varices in 15 (14.3%) patients.PPI therapy was used in 45.5% of patients (n=48).Seventeen (16.1%) patients presented with upper gastrointestinal bleeding;in 14/17 (82.3%) patients,bleeding was secondary to esophageal varices,and in 3/17 patients bleeding was attributed to portal hypertensive gastropathy.Bleeding related to portal hypertension according to PPI therapy occurred in 18.7% (n=9) of group 1 and in 14% (n=8) of group 2 (odds ratio:0.83,95% confidence interval:0.5-1.3,P=0.51).CONCLUSION:Portal hypertension bleeding is not associated with PPI use.These findings do not support the prescription of PPIs in patients with chronic liver disease with no currently accepted indication. | Mauricio Garcia-Saenz-de-Sicilia Francisco Sanchez-Avila Norberto C Chavez-Tapia Gustavo Lopez-Arce Sandra Garcia-Osogobio Roberto Ruiz-Cordero Felix I Tellez-Avila | 2010 | World Journal of Gastroenterology2010，16，46： | 6 |
| 2 | Trends in treatment and overall survival among patients with proximal esophageal cancer显示文摘BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures.Non-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been implemented.The trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease status.To optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life studies.AIM To establish trends in treatment and OS in patients with proximal esophageal cancer.METHODS In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry.The proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the incisors.Trends in radiotherapy,chemotherapy,and surgery,and OS were assessed.Analyses were stratified by presence of distant metastasis.Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment characteristics.RESULTS In total,2783 patients were included.Over the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,respectively.In metastatic disease,the use of chemotherapy and radiotherapy increased over time.Median OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on survival.In metastatic disease,median OS was 3.8 mo(95%CI:2.5-5.1)in 1989-1994,and 5.1 mo(95%CI:4.3-5.9)in 2010-2014(logrank P=0.26).CONCLUSION OS significantly improved in non-metastatic proximal esophageal cancer,likely to be associated with an increased use of CRT.Patterns in metastatic disease did not change significantly over time. | Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen | 2019 | World Journal of Gastroenterology2019，25，47： | 2 |
| 3 | Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration显示文摘 | Joanna M Wardlaw Eric E Smith Geert J Biessels Charlotte Cordonnier Franz Fazekas Richard Frayne Richard I Lindley John T O’Brien Frederik Barkhof Oscar R Benavente Sandra E Black Carol Brayne Monique Breteler Hugues Chabriat Charles DeCarli Frank-Erik de | 2013 | Lancet Neurology2013，，8： | 2 |
| 4 | Porter speciafion and population structure in the morphospecies Lutzomyia longipalpis (Lutz & Neiva) as derived from the mitochondrial ND4 Gene 显示文摘 | SANDRA I SOTO U LEHMANN T | 2001 | Mol Phylogen Evol2001，18，1： | 1 |
| 5 | Management of malignant pleural effusion and ascites by a triple access multi perforatedlarge diameter catheter port system显示文摘 | Ihsan I Sandra De S Patrick OM | 2008 | World J Surg Oncol2008，47，6： | 1 |
| 6 | Determination of fluoride ions released from resin - based dental materials using ion -selective electrode and ion chromatograph 显示文摘 | Toshiyuki I Thomas E C Sandra R | 2004 | J Dentistry2004，32，： | 1 |
| 7 | Mobility and safety in the multiple myeloma survivor:survivorship care plan of the International Myeloma Foundation Nurse Leadership Board 显示文摘 | Sandra I Rome H Bonnie S | 2011 | Clinical Journal of Oncolo- gy Nursing2011，12，15： | 1 |
| 8 | TLR5 stimulation is sufficient to trigger reactivation of latent HIV-1 provirus in T lymphoid cells and activate virus gene expression in central memory CD+4 T cells显示文摘 | Sandra T Michal I Mélanie R | 2009 | Virology2009，389，5： | 1 |
| 9 | Innate signaling and regulation of Dendritic cell immunity显示文摘 | Sandra J van Vliet Jeroen den Dunnen Sonja I Gringhuis Teunis BH Geijtenbeek Yvette van Kooyk | 2007 | Current Opinion in Immunology2007，，4： | 1 |
| 10 | Screening andconfirmation of chloramphenicol in shrimp tissue using ELISA in combination with GC-MS and LC-MS显示文摘 | Sandra I Wim R Jan V | 2003 | Analytica Chimica Acta2003，48，3： | 1 |
| 11 | An investigation of buffer sizing techniques in critical chain scheduling显示文摘 | Oya I Tukel Walter O Rom Sandra D Eksioglu | | 0，，02： | 1 |
| 12 | CINC-1 is an acute-phase protein induced by focal brain injury causing leukocyte mobilization and liver injury显示文摘 | SANDRA J C PAULA M H JOHN P I | | 0，，： | 1 |
| 13 | Suppressor of cytokirm signalling (SOCS) genea are expressed in the endomctrium and regulated by conceptus signals during early pregnancy in the ewe 显示文摘 | Sandra O BataiHon I Roux P | 2005 | J Mol Endocrinol2005，34，3： | 1 |
| 14 | Development of a Flexible Laser Ultrasonic Probe显示文摘 | Hopko Sandra N Ume I Charles Erdahl Dathan S | 2002 | Journal of Manufacturing Science and Engineering2002，124，2： | 1 |
| 15 | Vitellogenin induction in painted turtle, Chrysemys picta, as a biomarker of exposure to environmental levels of estradiol 显示文摘 | Lisa K I Sandra G Eva O | 2001 | Aquatic Toxicology2001，55，12： | 1 |
| 16 | Long-Term Care Insurance Purchase Patterns显示文摘 | Helen I Doerpinghaus Sandra G Gustavson | 2002 | Risk Management and Insurance Re- view2002，，1： | 1 |
| 17 | An investigation of buffer sizing techniques in critical chain seheduling显示文摘 | OYA I T WALTER O R SANDRA D E | 2006 | European Journal of Operational Research2006，172，2： | 1 |
| 18 | A kingdom level phylogeny of eukaryotes based on combined protein data显示文摘 | SANDRA L B ROGER A J WENKSIEFERT I | 2000 | Science2000，290，： | 1 |
| 19 | Highly active new α-diimine nickel catalyst for the polymerization of α-Olefins显示文摘 | Hua-Rong Liu Pedro T Gomes Sandra I Costa | 2005 | Journal of Organometallic Chemistry2005，690，： | 1 |
| 20 | Determination of fluoride ions released from resin-based dental materials using ionselective electrode and ion chromatograph 显示文摘 | Toshiyuki I Thormas E C Sandra R | 2004 | J Dentistry2004，32，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员