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| 1 | 欧洲卒中组织(ESO)关于无活动能力的急性缺血性卒中患者静脉血栓栓塞的预防指南显示文摘背景静脉血栓栓塞(venous thromboembolism, VTE)包括深静脉血栓形成(deep vein thrombosis, DVT)和肺栓塞,是无活动能力的急性缺血性卒中患者的常见并发症。本文阐述了欧洲卒中组织(European Stroke Organisation, ESO)关于无活动能力的急性缺血性卒中患者VTE预防的指南。有关出血性卒中的指南已发表。方法一个多学科小组确定了相关问题并使用推荐意见分级评估、制定和评价系统根据随机对照试验证据制定推荐意见。本文经过ESO内部及外部评审,并得到ESO指南委员会和ESO执行委员会批准。结果我们发现的主要是中等质量证据,包括评估梯度压力弹力袜(graduated compression stocking, GCS)、间歇充气加压装置(intermittent pneumatic compression, IPC)以及使用普通肝素(unfractionated heparin, UFH)、低分子量肝素(low molecular weight heparin, LMWH)和类肝素进行预防性抗凝治疗的随机对照试验和系统评价,但未发现评估神经肌肉电刺激(neuromuscular electrical stimulation, NES)的随机试验。我们推荐临床医生对无活动能力的患者使用IPC,但不应使用GCS。在无活动能力的缺血性卒中患者中,如果降低VTE风险的益处足以抵消其使用导致的颅内外出血风险增高,则应考虑使用UFH(5 000 U,2~3次/d)、LMWH或类肝素进行预防性抗凝治疗。如果确定具有预防性抗凝治疗的指征,应考虑使用LMWH或类肝素而非UFH,因为前两者能更明显地降低DVT风险,使用更加便利,人员成本更低,患者舒适度更高(每天仅需注射1次),但这些优势应与LMWH和类肝素的更高颅外出血风险、更高药物成本以及在肾功能不全老年患者中使用的相关风险进行权衡。结论IPC、UFH或LMWH和类肝素可降低无活动能力的急性缺血性卒中患者的VTE风险,但需要进一步研究来评价NES是否有效。其中证据最强的预防手段是IPC。需要更好的方法在卒中发病后最初数周内根据VTE风险和抗凝药的出血风险对患者进行分层。 | Martin Dennis Valeria Caso L Jaap Kappelle Aleksandra Pavlovic Peter Sandercock 刘品一 黄丽丽 徐运 | 2017 | 国际脑血管病杂志2017,25,3: | 11 |
| 2 | Cochrane脑卒中组简介显示文摘 | Hazel Fraser Brenda Thomas Peter Sandercock 曾亚莉 | 2005 | 中国循证医学杂志2005,5,2: | 6 |
| 3 | Modeling the dose-response rate/associations between VO2max and self-reported Physical Activity Questionnaire in children and adolescents显示文摘Background'. This study sought to explore the dose—response rate/association between aerobic fitness (VC)2max) and self-reported physical activity(PA) and to assess whether this association varies by sex, age, and weight status.Methods. VO2max was assessed using the 20・m shuttle・run test. PA was assessed using the Physical Activity Questionnaire (PAQ) for Adolescents(aged > 11 years, PAQ-A) or for Children (aged <11 years, PAQ-C). The associations between V02raax and PAQ were analyzed using analysisof covariance (ANCOVA), adopting PAQ and PAQ2 as covariates but allowing the intercepts and slope parameters of PAQ and PAQ2 tovary with the categorical variables sex, age group, and weight status.Results: ANCOVA identified a curvilinear association between VO2max and PAQ, with positive linear PAQ terms that varied for both sex andweight status but with a negative PAQ2 term of —0.39 (95% confidence interval (CI): —0.57 to —0.21) that was common for all groups in regardto age, sex, and weight status. These curvilinear (inverted U) associations suggest that the benefits of increasing PA (same dose) on VO2max isgreater when children report lower levels of PA compared to children who report higher levels of PA. These dose-response rates were alsosteeper for boys and were steeper for lean children compared to overweight/obese children.Conclusion'. Health practitioners should be aware that encouraging greater PA (same dose) in inactive and underweight children will result ingreater gains in V02max (response) compared with their active and overweight/obese counterparts. | Alan M.Nevill Michael J.Duncan Gavin Sandercock | 2020 | Journal of Sport and Health Science2020,9,1: | 5 |
| 4 | Blood Markers for the Prognosis of Ischemic Stroke: A Systematic Review显示文摘 | William Whiteley Wei Li Chong Anshuman Sengupta Peter Sandercock | 2009 | Stroke2009,,5: | 2 |
| 5 | Long-term survival after first-ever stroke显示文摘 | Burn JP Sandercock PA | 1993 | Stroke1993,24,6: | 1 |
| 6 | Anticoagulants for acute ischaemic stroke显示文摘 | Gubitz G Sandercock P Counsell C | 2004 | Cochrane Database Syst Rev2004,,00: | 1 |
| 7 | Acute heat stress-induced alterations in blood Acid-based status and skeletal muscle membrane in broiler chickens at two ages: implications for meat quality显示文摘 | Sandercock D A Hunter R R Nute G R | 2001 | Poultry Science2001,80,: | 1 |
| 8 | Indications for early aspirin use in acute ischemic stroke:A combined analysis of 40,000 randomized patients from the Chinese Acute Stroke Trial and the International Stoke trial显示文摘 | Chen Z M Sandercock P Pan H C | 2000 | Stroke2000,31,: | 1 |
| 9 | A prospective study of acute cerebrovascular disease in the community: the Oxford-shire Community Stroke Project Methodology, demography and incident cases of first-ever stroke 显示文摘 | Bamford J Sandercock P Dermis M et aI | 1988 | J Neurol Neurosurg Psychi-atry1988,51,11: | 1 |
| 10 | The frequency, causes and timing of death within 30 days of a first stroke: the Oxfordshire Community Stroke Pro-ject显示文摘 | Bamford J Dennis M Sandercock P | 1990 | J Neurol Neurosurg Psychiatry1990,53,10: | 1 |
| 11 | Chemical fingerprinting of unevaporated automotive gasoline samples 显示文摘 | SANDERCOCK P M L PASQUIER E Du | 2004 | Forensic Science International2004,140,: | 1 |
| 12 | Systematic reviews of animal experiments 显示文摘 | Sandercock P Roberts I | 2002 | Lancet2002,360,: | 1 |
| 13 | Inverted tandem duplication generates a duplication deficiency of chromosome 8p显示文摘 | Dill F J Schertzer M Sandercock J | 1987 | Clin Genet1987,32,: | 1 |
| 14 | Cost - Effectiveness of Thrombolysis With Recombinant Tissue Plasminogen Activator for Acute Ischemic Stroke Assessed by a Model Based on UK NHS Costs 显示文摘 | Sandercock P Berge E Dennis M | 2004 | Stroke2004,35,6: | 1 |
| 15 | Effect of intravenous corticosteroids on death within 14 days in 10008 adults with clinically significant head injury (MRC CRASH trial):randomised placebo-controlled trial显示文摘 | ROBERTS I YATES D SANDERCOCK P | 2004 | Lancet2004,364,9442: | 1 |
| 16 | Creatine kinase isoenzyme profiles in the plasma of the domestic fowl (Gallus domesticus): Effects of acute heat stress 显示文摘 | Mitchell M A Sandercock D A | 1995 | Res Vet Sci1995,59,: | 1 |
| 17 | Agreement between the clinical Oxfordshire Community Stroke Project classi- fication and CT findings in Poland显示文摘 | Wlodek A Sarzynska - Dlugosz I Sandercock PA | 2004 | Eur J Neuro2004,11,2: | 1 |
| 18 | Antiplatelet therapy for acute ischaemic stroke显示文摘 | Sandercock P Gubitz G Foley P | 2003 | Cochrane Database Syst Rev2003,,00: | 1 |
| 19 | The role of heart rate variability in prognosis for different modes of death in chronic heart failure显示文摘 | Sandercock GR Brodie DA | 2006 | Pacing Clin Electrophysiol2006,29,: | 1 |
| 20 | The benefits and harms of intrave- nous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute isch- aemic stroke (the Third Intemational Stroke Trial ): a randomised con- trolled trial显示文摘 | IST-3 COLLABORATIVE GROUP SANDERCOCK P WARDLAW JM | 2012 | Lancet2012,379,9834: | 1 |