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| 1 | The role of gut microbiota(commensal bacteria)and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer:contribution of germ-free and gnotobiotic animal models of human diseases显示文摘Metagenomic approaches are currently being used to decipher the genome of the microbiota(microbiome),and,in parallel,functional studies are being performed to analyze the effects of the microbiota on the host.Gnotobiological methods are an indispensable tool for studying the consequences of bacterial colonization.Animals used as models of human diseases can be maintained in sterile conditions(isolators used for germ-free rearing)and specifically colonized with defined microbes(including non-cultivable commensal bacteria).The effects of the germ-free state or the effects of colonization on disease initiation and maintenance can be observed in these models.Using this approach we demonstrated direct involvement of components of the microbiota in chronic intestinal inflammation and development of colonic neoplasia(i.e.,using models of human inflammatory bowel disease and colorectal carcinoma).In contrast,a protective effect of microbiota colonization was demonstrated for the development of autoimmune diabetes in non-obese diabetic(NOD)mice.Interestingly,the development of atherosclerosis in germ-free apolipoprotein E(ApoE)-deficient mice fed by a standard low-cholesterol diet is accelerated compared with conventionally reared animals.Mucosal induction of tolerance to allergen Bet v1 was not influenced by the presence or absence of microbiota.Identification of components of the microbiota and elucidation of the molecular mechanisms of their action in inducing pathological changes or exerting beneficial,disease-protective activities could aid in our ability to influence the composition of the microbiota and to find bacterial strains and components(e.g.,probiotics and prebiotics)whose administration may aid in disease prevention and treatment. | Helena Tlaskalova-Hogenova Renata Stepankova Hana Kozakova Tomas Hudcovic Luca Vannucci Ludmila Tuckova Pavel Rossmann TomasHrncır Miloslav Kverka Zuzana Zakostelska Klara Klimesova Jaroslava Pribylova Jirina Bartova Daniel Sanchez Petra Fundova Dana Borovska Dagmar Sru˚tkova Zdenek Zıdek Martin Schwarzer Pavel Drastich David P Funda | 2011 | Cellular & Molecular Immunology2011，8，2： | 47 |
| 2 | Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/SCID/IL2R[gamma]c-deficient mice显示文摘 | Sarry Jean-Emmanuel Murphy Kathleen Perry Robin Sanchez Patricia V Secreto Anthony Keefer Cathy Swider Cezary R Strzelecki Anne-Claire Cavelier Cindy Récher Christian Mansat-De Mas Véronique Delabesse Eric Danet-Desnoyers G Carroll Martin | 2011 | Journal of Clinical Investigation2011，，1： | 2 |
| 3 | 膜型巨噬细胞集落刺激因子对人脑胶质细胞瘤的免疫治疗作用显示文摘摘要 目的 探讨基因转染膜型巨噬细胞集落刺激因子(mM-CSF)对U251MG人脑胶质瘤细胞的免疫治疗作用。方法 用逆转录病毒载体将mM-CSF基因转入U251MG细胞,采用流式细胞术检测mM-CSF的表达;通过细胞毒性实验、兔疫组化方法以及观察转染细胞在免疫缺陷小鼠体内的生长情况研究mM-CSF对U251MG细胞的作用。结果①获得了表达mM-CSF的MG-2F11细胞;②大鼠巨噬细胞、人外周血淋巴细胞(PBL)和人单核细胞均可杀伤MG-2F11细胞,但不能杀伤U251MG母细胞;③接种瘤细胞到裸小鼠皮下18 h后,侵入MG-2F11肿瘤的巨噬细胞明显多于侵入MG-VV(仅转染病毒载体的U251MG细胞)肿瘤的巨噬细胞;④接种MG-2F11细胞的8只裸小鼠均无肿瘤生长,而接种MG-VV细胞的8只裸小鼠中的7只有肿瘤生长(P<0.01);另一免疫缺陷更严重的NIH-bg-nu-xidBR 小鼠,接种MG-2F11细胞后8只中的1只有肿瘤生长,而接种MG-VV细胞后8只中的7只有肿瘤生长(P<0.01)。结论mM-CSF转染的人脑胶质瘤细胞致瘤性降低,有进一步对其进行临床研究的必要。 | 陈义军 Cheri Lloyd Ramon Sanchez Martin R Jadus H Terry Wepsic | 2002 | 中华神经外科疾病研究杂志2002，1，3： | 2 |
| 4 | Bioshale FP6 European project: exploiting black shale ores using biotechnologies? 显示文摘 | D'HUGUES P NORRIS P R HALLBERG K SANCHEZ F LANGWALDT J GROTOWSKI A CHMIELEWSKI T GROUDEV S Bioshale consortium | 2007 | Minerals Engineering2007，21，： | 1 |
| 5 | Strategic Flexibility in Product Competition显示文摘 | SANCHEZ R | 1995 | Strategic Management Journal1995，，16： | 1 |
| 6 | Characterization of anthocyanin extracts from maize kernels显示文摘 | MORENO Y S SANCHEZ G S HERNANDEZ D R | 2005 | J Chromatogr Sci2005，43，： | 1 |
| 7 | CO2 Emissions Embodied in International Trade:Evidence for Spain显示文摘 | Sanchez C J Duarte R | 2004 | Energy Policy2004，32，18： | 1 |
| 8 | Strategic management at the point of inflection:systems,complexity and competence theory显示文摘 | SANCHEZ R | 1997 | Long Range Planning1997，30，6： | 1 |
| 9 | Modularity Flexibility, and Knowledge Management in Product and Organization Design 显示文摘 | SANCHEZ R MAHONEY J | 1996 | Strategic Management Journal1996，17，： | 1 |
| 10 | Continuous positive airway pressure treatment in sleep apnea pre- vents new vascular events after ischemic stroke 显示文摘 | Martnez Garca MA Galiano Blancart R Roman Sanchez P | 2005 | Chest2005，128，： | 1 |
| 11 | A simple technique for NURBS shape modification 显示文摘 | Sanchez R J | 1997 | IEEE Computer Graphics and Application1997，17，1： | 1 |
| 12 | A homoloque of an operon requred for DNA tranger in agrobacterium is required in Brucelluar multipeation 显示文摘 | Sieira R Comerci DJ Sanchez DO | 2000 | J Bact2000，182，17： | 1 |
| 13 | Diaphragmmatil hernia after transshiatal esophagectomy 显示文摘 | Tapia DJ Sanchez R Moreno M | 2000 | Rec Esp Anestesiol Reamin2000，7，2： | 1 |
| 14 | Effect of drillpipe rotation on hole cleaning during directional-well drilling显示文摘 | Sanchez R A Azar J A Bassal A A | 1999 | SPE Journal1999，4，2： | 1 |
| 15 | Increased transformation frequency and tagging of developmental genes in Aspergillus nidulans by restriction enzyme-mediated integration (REMI)显示文摘 | SANCHEZ O NAVARRO R E AGUIRRE J | 1998 | Mol Gen Genet1998，258，1： | 1 |
| 16 | Strategic product creation: managing new interactions of technology, markets, and organizations 显示文摘 | Sanchez R | 1996 | European Management Journal1996，14，2： | 1 |
| 17 | Perceived value of the purchase of a tourism product显示文摘 | Sanchez J Callarisa L Rodriguez R M | 2006 | Tourism Management2006，，3： | 1 |
| 18 | Ultra-trace determination of per- sistent organic pollutants in arctic ice using stir bar sorp- tive extraction and gas chromatography coupled to mass spectrometry 显示文摘 | Lacortea S Quintana J Taulera R Ventura F Tovar- Sanchez A Duarte CM | 2009 | J Chromatogr A2009，1216，49： | 1 |
| 19 | New evi- dences on the catalase mechanism of microbial corrosion 显示文摘 | Busalmen J P Vazquez M De Sanchez S R | 2002 | Electrochim Aeta2002，47，12： | 1 |
| 20 | Line-derived neurotrophic factor and partially restores tyrosine hydroxylase expression in suhstantia nigra and striatum显示文摘 | Sanchez B Relova JL Gallego R | 2009 | J Neurosci Res2009，87，1： | 1 |
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