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| 1 | HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity显示文摘 | Clement V Sanchez P de Tribolet N Radovanovic I Ruiz i Altaba A | 2007 | 中国神经肿瘤杂志2007，5，2： | 96 |
| 2 | The role of gut microbiota(commensal bacteria)and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer:contribution of germ-free and gnotobiotic animal models of human diseases显示文摘Metagenomic approaches are currently being used to decipher the genome of the microbiota(microbiome),and,in parallel,functional studies are being performed to analyze the effects of the microbiota on the host.Gnotobiological methods are an indispensable tool for studying the consequences of bacterial colonization.Animals used as models of human diseases can be maintained in sterile conditions(isolators used for germ-free rearing)and specifically colonized with defined microbes(including non-cultivable commensal bacteria).The effects of the germ-free state or the effects of colonization on disease initiation and maintenance can be observed in these models.Using this approach we demonstrated direct involvement of components of the microbiota in chronic intestinal inflammation and development of colonic neoplasia(i.e.,using models of human inflammatory bowel disease and colorectal carcinoma).In contrast,a protective effect of microbiota colonization was demonstrated for the development of autoimmune diabetes in non-obese diabetic(NOD)mice.Interestingly,the development of atherosclerosis in germ-free apolipoprotein E(ApoE)-deficient mice fed by a standard low-cholesterol diet is accelerated compared with conventionally reared animals.Mucosal induction of tolerance to allergen Bet v1 was not influenced by the presence or absence of microbiota.Identification of components of the microbiota and elucidation of the molecular mechanisms of their action in inducing pathological changes or exerting beneficial,disease-protective activities could aid in our ability to influence the composition of the microbiota and to find bacterial strains and components(e.g.,probiotics and prebiotics)whose administration may aid in disease prevention and treatment. | Helena Tlaskalova-Hogenova Renata Stepankova Hana Kozakova Tomas Hudcovic Luca Vannucci Ludmila Tuckova Pavel Rossmann TomasHrncır Miloslav Kverka Zuzana Zakostelska Klara Klimesova Jaroslava Pribylova Jirina Bartova Daniel Sanchez Petra Fundova Dana Borovska Dagmar Sru˚tkova Zdenek Zıdek Martin Schwarzer Pavel Drastich David P Funda | 2011 | Cellular & Molecular Immunology2011，8，2： | 47 |
| 3 | Assessing impacts of different land use scenarios on water budget of Fuhe River,China using SWAT model显示文摘The Soil and Water Assessment Tool(SWAT)model was used to assess the impacts of different land use scenarios on hydrological processes in the Fuhe watershed in Poyang Lake Basin,East China.A total of 12 model parameters were calibrated with observed monthly runoff data for 1982-1988 and validated for 1991-1998 for baseline conditions.The baseline test results of R2 and Nash-Sutcliffe model efficiency(NSE)values ranged between 0.88 and 0.94 across the calibration and validation periods,indicating that SWAT accurately replicated the Fuhe watershed streamflow.Several different land use scenarios were then simulated with the model,focusing on the impacts of land use change on the hydrology of the watershed.The results of hypothetical scenario simulations revealed that surface runoff declined while groundwater recharge and evapotranspiration(ET)increased,as forest land,agriculture land and/or grassland areas increased,as well as when paddy field and urban areas decreased.These results further showed that forest land has a higher capacity to conserve the water as compared to pasture land.The results of the real scenario simulations revealed that urbanization is the strongest contributor to changes in surface runoff,water yield,and ET.Urbanization can be considered as a potential major environmental stressor controlling hydrological components. | Tao Can Chen Xiaoling Lu Jianzhong Philip W.Gassman Sauvage Sabine Sanchez Pérez José-Miguel | 2015 | International Journal of Agricultural and Biological Engineering2015，8，3： | 4 |
| 4 | Solitary keratoacanthoma:a self-healing proliferation that frequently becomes malignant显示文摘 | Sanchez Yus E Simon P Requena L | 2000 | Am J Dermatopathol2000，22，4： | 2 |
| 5 | Bioshale FP6 European project: exploiting black shale ores using biotechnologies? 显示文摘 | D'HUGUES P NORRIS P R HALLBERG K SANCHEZ F LANGWALDT J GROTOWSKI A CHMIELEWSKI T GROUDEV S Bioshale consortium | 2007 | Minerals Engineering2007，21，： | 1 |
| 6 | Anti - faetor Xa kinetics after intravenous enoxaparin in patients under-going percutaneous coronary intervention: a population model analysis 显示文摘 | Sanchez - Pena P Hulot JS Urinen S | 2005 | Br Clin Pharmacol2005，60，： | 1 |
| 7 | Heart preservation for transplantation:principles and strategies 显示文摘 | Jahania MS Sanchez JA Narayan P | 1999 | Ann Thorac Surg1999，68，5： | 1 |
| 8 | Renal agenesis and the absence of enteric neurons in mice lacking GDNF显示文摘 | SANCHEZ INMACULIDA SILOS SANTIAGO | 1996 | Nature1996，382，： | 1 |
| 9 | Pathways and consequences:Hedgehog signaling in human disease显示文摘 | Mullor JL Sanchez P Ruizi AA | 2002 | Trends Cell Biol2002，12，12： | 1 |
| 10 | The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation显示文摘 | Sanz L Sanchez P Lallena M J | 1999 | EMBO J1999，18，11： | 1 |
| 11 | Continuous positive airway pressure treatment in sleep apnea pre- vents new vascular events after ischemic stroke 显示文摘 | Martnez Garca MA Galiano Blancart R Roman Sanchez P | 2005 | Chest2005，128，： | 1 |
| 12 | Maturity and stability parameters of composts prepared with a wide range of organic wastes显示文摘 | Bernal M P Paredes C Sanchez - Monedero M A | 1998 | Bioresource Technology1998，63，： | 1 |
| 13 | 显示文摘 | Garcia Sanchez MV Lopez Vallejos P Perez deLuque D | 2004 | Rev Esp Enferm Dig2004，96，5： | 1 |
| 14 | The abi1-1 mutation blocks ABA signaling downstream of cADPR action显示文摘 | Wu Y Sanchez J P Lopez-Molina L | 2003 | Plant J2003，34，： | 1 |
| 15 | Rcitalopram counteracts the antidepressant like effect of escitalopram in a rat chronic mild stress model of de2pression 显示文摘 | Sanchez C Gruca P Papp M | 2003 | Behav Pharmacol2003，14，： | 1 |
| 16 | The development of university spin-offs:early dynamics of technology transfer and net- working显示文摘 | PEREZ M P SANCHEZ A M | 2003 | Technovation2003，23，10： | 1 |
| 17 | Régimen alimentario de Illex coindetii (Verany,1837) en el mar Catalán显示文摘 | SANCHEZ P | | 0，，3： | 1 |
| 18 | Zinc alpha-2-gly- coprotein is expressed by malignant prostatic epithelium and may serve as a potential serum marker for prostate cancer 显示文摘 | Hale L P Price D T Sanchez L M | 2001 | Clin Cancer Res2001，7，4： | 1 |
| 19 | Severe acute exacerbations and mortality in patients with chronic obstructive pulmonary disease显示文摘 | Soler-Catalua JJ Martinez-Garcia MA Roman Sanchez P | 2005 | Thorax2005，60，11： | 1 |
| 20 | New evi- dences on the catalase mechanism of microbial corrosion 显示文摘 | Busalmen J P Vazquez M De Sanchez S R | 2002 | Electrochim Aeta2002，47，12： | 1 |
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