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| 1 | 3D additive manufactured composite scaffolds with antibiotic-loaded lamellar fillers for bone infection prevention and tissue regeneration显示文摘Bone infections following open bone fracture or implant surgery remain a challenge in the orthopedics field.In order to avoid high doses of systemic drug administration,optimized local antibiotic release from scaffolds is required.3D additive manufactured(AM)scaffolds made with biodegradable polymers are ideal to support bone healing in non-union scenarios and can be given antimicrobial properties by the incorporation of antibiotics.In this study,ciprofloxacin and gentamicin intercalated in the interlamellar spaces of magnesium aluminum layered double hydroxides(MgAl)andα-zirconium phosphates(ZrP),respectively,are dispersed within a thermoplastic polymer by melt compounding and subsequently processed via high temperature melt extrusion AM(~190◦C)into 3D scaffolds.The inorganic fillers enable a sustained antibiotics release through the polymer matrix,controlled by antibiotics counterions exchange or pH conditions.Importantly,both antibiotics retain their functionality after the manufacturing process at high temperatures,as verified by their activity against both Gram+and Gram-bacterial strains.Moreover,scaffolds loaded with filler-antibiotic do not impair human mesenchymal stromal cells osteogenic differentiation,allowing matrix mineralization and the expression of relevant osteogenic markers.Overall,these results suggest the possibility of fabricating dual functionality 3D scaffolds via high temperature melt extrusion for bone regeneration and infection prevention. | María C´amara-Torres Stacy Duarte Ravi Sinha Ainhoa Egizabal Noelia´Alvarez Maria Bastianini Michele Sisani Paolo Scopece Marco Scatto Alessandro Bonetto Antonio Marcomini Alberto Sanchez Alessandro Patelli Carlos Mota Lorenzo Moroni | 2021 | Bioactive Materials2021，6，4： | 2 |
| 2 | Predictors of progression in Barrett’s esophagus II: baseline 17p (p53) loss of heterozygosity identifies a patient subset at increased risk for neoplastic progression显示文摘 | Brian J Reid Laura J Prevo Patricia C Galipeau Carissa A Sanchez Gary Longton Douglas S Levine Patricia L Blount Peter S Rabinovitch | 2001 | The American Journal of Gastroenterology2001，，10： | 2 |
| 3 | A human ESC model for MLL-AF4 leukemic fusion gene reveals an impaired early hematopoietic-endothelial specification显示文摘MLL-AF4 熔化基因是在在婴儿的高风险的尖锐成淋巴细胞的白血病的一个特点 genomic 错误。尽管 MLL-AF4 在人的开发期间出生前地产生,这很好被建立,它在在 utero 的造血的开发的效果仍然保持未经勘探。我们创造了一个人特定的细胞的系统在 MLL-AF4-expressing 人的胚胎的干细胞(hESCs ) 学习早 hemato-endothelial 开发。介绍的功能的研究,同种细胞的分析和基因表示表明在 hESCs 的 MLL-AF4 的那表情有 phenotypic,功能并且基因表示影响。MLL-AF4 在 hESCs 充当全球 transcriptional 使活跃之物和 homeobox 基因表示的一个积极管理者。机能上地, MLL-AF4 从 hESCs 提高 hemogenic 先锋的说明,但是强烈损害进一步造血的承诺赞成 endothelial 房间命运。MLL-AF4 hESCs transcriptionally 被告知向对 endothelial 成熟敏感的 hemogenic 先锋区分,由联系到 vascular-endothelial 功能和早造血作用的主人基因的显著 upregulation 思考了。而且,我们报导那 MLL-AF4 表情不是足够的转变导出 hESC 的造血的房间。这个工作说明 hESCs 怎么可以提供唯一的卓见进人的开发并且推进我们理解白血病的熔化基因,知道出生前地产生,调整人的胚胎的造血的说明。 | Clara Bueno Rosa Montes Gustavo J Melen Verdnica Ramos-Mejia Pedro J Real Ver6nica Ayllo'n Laura Sanchez Gertmdis Ligero Inmaculada Gutierrez-Aranda Agustin F Femfindez Mario F Fraga Inmaculada Moreno-Gimeno Deborah Btlrks Maria del Carmen Plaza-Calonge Juan C Rodriguez-Manzaneque Pablo Menendez | 2012 | Cell Research2012，22，6： | 2 |
| 4 | A retrospective analysis of pharmacokinetic-pharmacodynamic parameters as indicators of the clinical efficacy of ceftizoxime 显示文摘 | Sanchez-Navarro A Colino C I Sanchez Recio M M | 2001 | Clin Pharmacokinet2001，40，2： | 2 |
| 5 | Escitalopram, the S ( + ) enantiomer of citalopram,is a selective serotonin reuptake inhibitor with potent effects in animal models predictive of antidepressant and anxiolytie activities 显示文摘 | Sanchez C Bergqvist PB Brennum LT | 2003 | Psychopharmacology ( Bed )2003，167，： | 1 |
| 6 | Manipulation of dopamine D1-like receptor activation in the rat medial prefrontal cortex alters stress- and cocaine-induced reinstatement of conditioned place preference behavior显示文摘 | Sanchez C J Bailie TM Wu WR | 2003 | Neuroscience2003，119，： | 1 |
| 7 | Synthesis and characterization of titanium oxide - based gels synthesized from acetate modified titanium butoxide precursors 显示文摘 | Barboux - Doeuff S SANCHEZ C | 1994 | Materials Research Bulletin1994，29，： | 1 |
| 8 | Depression and poor sleep:the effect of monoaminergic antidepressants in a pre-clinical model in rats显示文摘 | SANCHEZ C BRENNUM L T STORUSTOVU S | 2007 | Pharmacol Biochem Behav2007，86，3： | 1 |
| 9 | CO2 Emissions Embodied in International Trade:Evidence for Spain显示文摘 | Sanchez C J Duarte R | 2004 | Energy Policy2004，32，18： | 1 |
| 10 | Differentiating between malignant and idiopathic pleural effusions:the value of diagnostic procedures显示文摘 | Aleman C Sanchez L Alegre J | 2007 | QJM2007，100，： | 1 |
| 11 | Abnormalities of the APC/beta-catenin pathway in endometrial cancer 显示文摘 | Moreno-Bueno G Hardisson D Sanchez C | 2002 | Oncogene2002，21，52： | 1 |
| 12 | Interception of the electron transport chain in bacteria with hydrophilic redox mediators显示文摘 | Lithgow A M Romero L Sanchez I C | 1986 | J Chem Res Synop1986，，5： | 1 |
| 13 | Maturity and stability parameters of composts prepared with a wide range of organic wastes显示文摘 | Bernal M P Paredes C Sanchez - Monedero M A | 1998 | Bioresource Technology1998，63，： | 1 |
| 14 | Unsaturated polyester resins: influence of the styrene concentrationon the miscibility and mechanical properties 显示文摘 | SANCHEZ E M S ZAVAGLIA C A C FELISBERTI M I | 2000 | Polymer2000，41，： | 1 |
| 15 | The 1999 SWISS-2DPAGE database update显示文摘 | Hoogland C Sanchez JC Tonella L | 2000 | Nucleic Acids Res2000，28，1： | 1 |
| 16 | Hepatocyte growth factor/cmet signaling pathway is required for efficient liver regeneration and repair显示文摘 | Huh C G Factor V M Sanchez A | 2004 | Proc Natl Acad Sci USA2004，101，13： | 1 |
| 17 | Rcitalopram counteracts the antidepressant like effect of escitalopram in a rat chronic mild stress model of de2pression 显示文摘 | Sanchez C Gruca P Papp M | 2003 | Behav Pharmacol2003，14，： | 1 |
| 18 | Cryopreservation of chest- nut by vitrification of in vitro-grown shoot tips 显示文摘 | Vidal N Sanchez C Jorquera L | 2005 | In Vitro Cell Dev-P12005，41，1： | 1 |
| 19 | Identification of failure type in corroded pipelines : A Bayesian probabilistic approach 显示文摘 | BRETON T SANCHEZ G H C ALAMILLA J L | 2010 | Journal of Hazardou Materials2010，179，13： | 1 |
| 20 | Dual-phase helical CT of pancreatic adenocarcinoma: assessment of resectability before surgery 显示文摘 | Vails C Andia E Sanchez A | 2002 | A JR Am J Roentgenol2002，178，4： | 1 |
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