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| 1 | 5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages显示文摘5-Hydroxymethylcytosine (5hmC ) 是被连接了到基因规定和癌症致病的重要哺乳动物的 DNA epigenetic 修正。这里,我们用定序途径的一枝敏感化学基于标签的低输入的猎枪在传播没有房间的 DNA (cfDNA ) 探索了 5hmC 的诊断潜力。我们从七种不同癌症类型的 49 个病人定序没有房间的 5hmC 并且发现了能被用来与高精确性预言癌症类型和阶段的不同特征。明确地,我们发现肺癌症在 cfDNA 导致 5hmC 的进步全球损失,而 hepatocellular 癌和胰腺的癌症在没有房间的 hydroxymethylome 导致疾病特定的变化。我们的 proof-of-principle 结果建议没有房间的 5hmC 签名可以潜在地被使用不仅识别癌症类型而且在一些癌症追踪肿瘤舞台。 | Chun-Xiao Song Senlin Yin Li Ma Amanda Wheeler Yu Chen Yan Zhang Bin Liu Junjie Xiong Weihan Zhang Jiankun Hu Zongguang Zhou Biao Dong Zhiqi Tian Stefanie S Jeffrey Mei-Sze Chua Samuel So Weimin Li Yuquan Wei Jiajie Diao Dan Xie Stephen R Quake | 2017 | Cell Research2017，27，10： | 17 |
| 2 | Epigenetics in hepatocellular carcinoma: An update and future therapy perspectives显示文摘Hepatocellular carcinoma(HCC),the predominant form of adult liver malignancies,is a global health concern.Its dismal prognosis has prompted recent significant advances in the understanding of its etiology and pathogenesis.The deregulation of epigenetic mechanisms,which maintain heritable gene expression changes and chromatin organization,is implicated in the development of multiple cancers,including HCC.This review summarizes the current knowledge of epigenetic mechanisms in the pathogenesis of HCC,with an emphasis on HCC mediated by chronic hepatitis B virus infection.This review also discusses the encouraging outcomes and lessons learnt from epigenetic therapies for hematological and other solid cancers,and highlights the future potential of similar therapies in the treatment of HCC. | Li Ma Mei-Sze Chua Ourania Andrisani Samuel So | 2014 | World Journal of Gastroenterology2014，20，2： | 12 |
| 3 | 改良DBL法测定稻米中的赖氨酸含量显示文摘 | 王红梅 刘巧泉 Joyce W C Ma Samuel S M Sun | 2002 | 扬州大学学报(农业与生命科学版)2002，23，4： | 5 |
| 4 | Medical training fails to prepare providers to care for patients with chronic hepatitis B infection显示文摘AIM: To investigate physicians' knowledge including chronic hepatitis B(CHB) diagnosis, screening, and management in various stages of their training.METHODS: A voluntary 20-question survey was administered in Santa Clara County, CA where Asian and Pacific Islanders(API) account for a third of the population. Among the 219 physician participants,there were 63 interns, 60 second-year residents, 26 chief residents and 70 attending physicians. The survey asked questions regarding respondents' demographics,general hepatitis B virus knowledge questions(i.e.,transmission, prevalence, diagnostic testing, prevention,and treatment options), as well as, self-reported practice behavior and confidence in knowledge.RESULTS: Knowledge about screening and managing patients with CHB was poor: only 24% identified the correct tests to screen for CHB, 13% knew the next steps for patients testing positive for CHB, 18% knew the high prevalence rate among API, and 31% knew how to screen for liver cancer. Wald chi-square analysis determined the effect of training level on knowledge; in all cases except for knowledge of liver cancer screening(p = 0.0032), knowledge did not significantly increase with length in residency training or completion of residency.CONCLUSION: Even in a high-risk region, both medical school and residency training have not adequatelyprepared physicians in the screening and management of CHB. | Stephanie D Chao Bing-Mei Wang Ellen T Chang Li Ma Samuel K So | 2015 | World Journal of Gastroenterology2015，21，22： | 2 |
| 5 | In vivo genome editing thrives with diversified CRISPR technologies显示文摘Prokaryotic type Ⅱ adaptive immune systems have been developed into the versatile CRISPR technology, which has been widely applied in sitespecific genome editing and has revolutionized biomedical research due to its superior efficiency and flexibility. Recent studies have greatly diversified CRISPR technologies by coupling it with various DNA repair mechanisms and targeting strategies.These new advances have significantly expanded the generation of genetically modified animal models, either by including species in which targeted genetic modification could not be achieved previously, or through introducing complex genetic modifications that take multiple steps and cost years to achieve using traditional methods. Herein, we review the recent developments and applications of CRISPR-based technology in generating various animal models, and discuss the everlasting impact of this new progress on biomedical research. | Xun Ma Avery Sum-Yu Wong Hei-Yin Tam Samuel Yung-Kin Tsui Dittman Lai-Shun Chung Bo Feng | 2018 | Zoological Research2018，39，2： | 2 |
| 6 | Comparison of laser phacovaporization using the Er-YAG and the Er-YSGG laser显示文摘 | Gailitis RP Patterson SW Samueles MA | 2003 | Arch Ophthalmol2003，111，： | 1 |
| 7 | Analysis of the genome to personalize therapy for melanoma显示文摘 | Davies MA Samuels Y | 2010 | Oncogene2010，29，： | 1 |
| 8 | Factors thatinfluence nurses,job satisfaction 显示文摘 | Ma CC Samuels ME Alexander JW | 2003 | J NursingAdministration2003，33，5： | 1 |
| 9 | Factors that influence nurses'job satisfaction显示文摘 | Ma CC Samuels ME Alexander JW | 2003 | J Nurs Adm2003，33，5： | 1 |
| 10 | Use of a noninvasive continuous monitoring device in the management of atrial fibrillation : a pilot study显示文摘 | Rosenberg MA Samuel M Thosani A | 2013 | Pa- cing Clin Electrophysio12013，36，3： | 1 |
| 11 | The brain-heart connection 显示文摘 | Samuels MA | 2007 | Circulation2007，116，1： | 1 |
| 12 | A study of tensile properties in A1-Si-Cu and A1-Si-Mg alloys: Effect of/3-iron intermetallics and porosity显示文摘 | MA Z SAMUEL A M SAMUEL F H DOTY H W VALTIERRA S | 2008 | Materials Science and Engineering A2008，490，12： | 1 |
| 13 | Long- term outcomes of therapeutic lymphadenectomy for stage I endometrial adenocarcinoma显示文摘 | Mohan DS Samuels MA Selim MA | 1998 | Gynecol Oncol1998，70，： | 1 |
| 14 | A study of tensile properties in AI-Si-Cu and AI-Si-Mg alloys : Effect of b-iron intermetallics and porosity 显示文摘 | Ma Z Samuel A Samuel F | 2008 | Materials Science and Engineering A2008，490，： | 1 |
| 15 | Factors that influence nurseg job satisfaction显示文摘 | Ma CC Samuels ME Alexander JW | 2003 | J Nurs Adm2003，33，5： | 1 |
| 16 | Comparison of laser phacoemulsification using the erbium:YAG lasers显示文摘 | Gallitis RP Patterson SW Samuels MA | 1993 | Arch Ophthalmol1993，111，： | 1 |
| 17 | Neurogenic heart disease:A unifying hypothesis显示文摘 | Samuels MA | 1987 | AM J Cardiol1987，60，： | 1 |
| 18 | Neurogenic heart disease:A unifying hypothesis显示文摘 | | 1987 | AM J Cardiol1987，60，18： | 1 |
| 19 | The brain-heart connection显示文摘 | Samuels MA | 2007 | Circulation2007，116，1： | 1 |
| 20 | Retinopathy of preraaturity: Pratical sur gieal managemetn in the new millennium显示文摘 | Tawansy KA Samuel MA | 2004 | Techniques Ophtalmol2004，2，4： | 1 |
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