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| 1 | Pancreatic regenerating protein (regⅠ) and regⅠreceptor mRNA are upregulated in rat pancreas after induction of acute pancreatitis显示文摘AIM: Pancreatic regenerating protein (regⅠ) stimulates pancreatic regeneration after pancreatectomy and is mitogenic to ductal andβ-cells. This suggests that regⅠand its receptor may play a role in recovery after pancreatic injury. We hypothesized that regⅠand its receptor are induced in acute pancreatitis. METHODS: Acute pancreatitis was induced in male Wistar rats by retrograde injection of 3% sodium taurocholate into the pancreatic duct. Pancreata and serum were collected 12, 24, and 36 hours after injection and from normal controls (4 rats/group). RegⅠreceptor mRNA, serum regⅠprotein, and tissue regⅠprotein levels were determined by Northern analysis, enzyme-linked immunosorbent assay (ELISA), and Western analysis, respectively. Immunohistochemistry was used to localize changes in regⅠand its receptor. RESULTS: Serum amylase levels and histology confirmed necrotizing pancreatitis in taurocholate treated rats. There was no statistically significant change in serum regⅠconcentrations from controls. However, Western blot demonstrated increased tissue levels of regⅠat 24 and 36 h. This increase was localized primarily to the acinar cells and the ductal cells by immunohistochemistry. Northern blot demonstrated a significant increase in regⅠreceptor mRNA expression with pancreatitis. Immunohistochemistry localized this increase to the ductal cells, islets, and acinar cells. CONCLUSION: Acute pancreatitis results in increased tissue regⅠprotein levels localized to the acinar and ductal cells, and a parallel threefold induction of regⅠreceptor in the ductal cells, islets, and acinar cells. These changes suggest that induction of reg I and its receptor may be important for recovery from acute pancreatitis. | Martin H Bluth Sameer A Patel Brian K Dieckgraefe Hiroshi Okamoto Michael E Zenilman | 2006 | World Journal of Gastroenterology2006，12，28： | 19 |
| 2 | Structure and stability of Ba - Cu - Ge type - I clathrates显示文摘 | Yang Li Sameer Khandekar Joseph H | 2003 | J Phys Condens Matter2003，15，： | 1 |
| 3 | Patterns of tourists' emotional responses,satisfaction,and intention to recommend显示文摘 | SAMEER H GIRISH P | | 0，，： | 1 |
| 4 | Synthesis of TiB2- TiC/Fe nano-eomposite coating by laser surface engineering 显示文摘 | Du B H Sameer R P Narendra B D | 2013 | Optics & Laser Technology2013，45，： | 1 |
| 5 | Destination image and destination personality: an application of branding theories to tourism places显示文摘 | Sameer H Yuksel E Muzaffer U | 2006 | Journal of Business Research2006，59，5： | 1 |
| 6 | Reduced lignin content and altered lignin composition in transgenic tobacco down-regulated in expression of L-phenylalanine ammonia-lyase or cinnamate 4-hydroxylase显示文摘 | Vincent J H S Weiting N Jack W B Hans G J Sameer A M Paul A H Chris L and Richard A D | | 0，，： | 1 |
| 7 | Biodegradation of petroleum hydrocarbons in a soil containing polyacrylamide显示文摘 | Sameer L E Erickson S L H Karthikeyan R | 2002 | The integrated petroleum environmental consortium2002，21，5： | 1 |
| 8 | Newsvendor pull-to-center reconsidered显示文摘 | LAU N SAMEER H NEIL B | 2014 | Decision Support Systems2014，58，2： | 1 |
| 9 | Folate:metabolism,genes,polymorphisms and the associated diseases显示文摘 | Nazki F H Sameer A S Ganaie B A | | 0，，01： | 1 |
| 10 | Scheduling in Flowshops to Minimize Total Tardiness of Jobs显示文摘 | Sameer H Chandrasekharan R | 2004 | Int J of Production Research2004，42，12： | 1 |
| 11 | Analysis of nucleation kinetics of poorly water-soluble drugs in presence of ultrasound and hydroxypropyl methyl cellulose during antisolvent precipitation显示文摘 | SAMEER V DALVI H DAVE R N | 2010 | International Journal of Pharmaceutics2010，387，： | 1 |
| 12 | Biodegradation of petroleum hydrocarbons in a soil containing polyacrylamide显示文摘 | Sameer L E Erickson S L H Karthikeyan R | 2002 | 21(5):1072002，21，5： | 1 |
| 13 | General coping strategies and their impact on quality of life in older adults with schizophrenia显示文摘 | CARL I C SAMEER K H NURUN B | 2011 | schizophrenia RES2011，127，13： | 1 |
| 14 | Newsvendor pull-to-center reconsidered显示文摘 | Lan N Sameer H Neil B | 2014 | Decision Support Systems2014，58，2： | 1 |
| 15 | Revisiting niacin: reviewing the evidence 显示文摘 | Christopher S Ramadan A Sameer H | 2007 | Clin Lipidol2007，1，4： | 1 |
| 16 | Newsvendor pull-to-center reconsidered显示文摘 | Lan N Sameer H Neil B | 2014 | Decision Support Systems2014，58，2： | 1 |
| 17 | Assess-ment of novel ureteral occlusion device and comparison withstone cone in prevention of stone fragment migration duringlithotripsy显示文摘 | PAULETTER H G SAMEER S K PERRY K T | 2005 | J Endourol2005，19，5： | 1 |
| 18 | Rate effect on pullout behavior of steel fibers embedded in very-high strength concrete 显示文摘 | Taher A L Sameer H Brian Z | 2010 | American Journal of Engineering & Ap- plied Sciences2010，3，2： | 1 |
| 19 | A taxonomy of wireless micro-sensor network models显示文摘 | SAMEER T NAEL B WENDI H | | 0，，2： | 1 |
| 20 | London residents’ support for the 2012 Olympic Games:the mediating effect of overall attitude显示文摘 | GIRISH P SAMEER H ROBIN N | 2013 | Tourism management2013，36，6： | 1 |
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