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4篇 您的检索式:作者名="Samar Mansour"
    题名 作者 年代 出处 被引量
1Postoperative Complications After Primary Adult Optical Penetrating Keratoplasty: Prevalence and Impact on Graft Survival显示文摘Michael D Wagoner Rola Ba-Abbad Mansour Al-Mohaimeed Samar Al-Swailem M Bridget Zimmerman 2009Cornea2009,,4:1
2Ocular Poloxamer-Based Ciprofloxacin Hydrochloride In Situ Forming Gels显示文摘Mai Mansour Samar Mansour Nahed D. Mortada Seham S. Abd ElHady 2008Drug Development and Industrial Pharmacy2008,,7:1
3Vesicular aceclofenac systems: A comparative study between liposomes and niosomes显示文摘Maha Nasr Samar Mansour Nahed D 2008Journal of Microencapsulation2008,25,7:1
4Novel technique of insulin loading into porous carriers for oral delivery显示文摘The increasing demand for oral macromolecule delivery encouraged the development of mi-croencapsulation technologies to protect such drugs against gastric and enzymatic degra-dation. However, microencapsulation often requires harsh conditions that may jeopardizetheir biological activity. Accordingly, many trials attempted to load macromolecules intoporous drug carriers to bypass any formulation induced instability. In this study, we pre-pared chitosan coated porous poly(d, l-lactide-co-glycolide)(PLGA) microparticles(MPs)loaded with insulin using a novel loading technique; double freeze-drying. The resultsshowed a significant increase in drug loading using only 5 mg/ml initial insulin concen-tration and conveyed a sustained drug release over uncoated MPs. Furthermore, SEM andconfocal microscopy confirmed pore blocking and insulin accumulation within the MPs re-spectively. The oral pharmacodynamic data on rats also proved the preservation of insulinbioactivity after formulation. Finally, the new coating technique proved to be efficient inproducing robust layer of chitosan with higher insulin loading while maintaining insulinactivity.Sarah Y.Eilleia Mahmoud E.Soliman Samar Mansour Ahmed.S.Geneidi 2018Asian Journal of Pharmaceutical Sciences2018,13,4:1
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