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| 1 | Fecal lactoferrin accurately reflects mucosal inflammation in inflammatory bowel disease显示文摘BACKGROUND Studies have demonstrated a potential role for fecal biomarkers such as fecal calprotectin(FC)and fecal lactoferrin(FL)in monitoring inflammatory bowel diseases(IBD)-Crohn's disease(CD)and ulcerative colitis(UC).However,their correlation to endoscopic scores,disease severity and affected intestinal surface has not been extensively investigated.AIM To correlate FL,and for comparison white blood cell(WBC)and C-reactive protein(CRP),with endoscopic scores,disease extent and location in CD and UC.METHODS Retrospective analysis in 188 patients who had FL,CRP and WBC determined within 30 d of endoscopy.Disease location,disease extent(number of intestinal segments involved),disease severity(determined by endoscopic scores),timing of FL testing in relation to colonoscopy,as well as the use of effective fast acting medications(steroids and biologics)between colonoscopy and FL measurement,were recorded.RESULTS In 131 CD and 57 UC patients,both CRP and FL-but not WBC-distinguished disease severity(inactive,mild,moderate,severe).In patients receiving fastacting(steroids or biologics)treatment in between FL and colonoscopy,FL showed a higher correlation to endoscopic scores when tested before vs after the procedure(r=0.596,P<0.001,vs r=0.285,P=0.15 for the Simple Endoscopic Score for CD;and r=0.402,P=0.01 vs r=0.054 P=0.84 for Disease Activity Index).Finally,FL was significantly correlated with the diseased mucosal surface(colon-ileocolon>small bowel)and the number of inflamed colon segments.CONCLUSION FL and CRP separated disease severity categories with FL showing lower discriminating P-values.FL showed a close correlation with the involved mucosal surface and with disease extent and was more closely correlated to endoscopy when determined before the procedure–this indicating that inflammatory activity changes associated with therapy might be rapidly reflected by FL levels.FL can accurately and timely characterize intestinal inflammation in IBD. | Marrieth G Rubio Kofi Amo-Mensah James M Gray Vu Q Nguyen Sam Nakat Douglas Grider Kim Love James H Boone Dario Sorrentino | 2019 | World Journal of Gastrointestinal Pathophysiology2019，10，5： | 4 |
| 2 | Dabigatran etixilate and traumatic brain injury: Evolving anticoagulants require evolving care plans显示文摘AIM: To investigate the outcomes of trauma patients with traumatic brain injury(TBI) on Dabigatran Etexilate(DE). METHODS: Following IRB approval, all patients taking DE who were admitted to our level 1 trauma service were enrolled in the study. Injury complexity, length of stay(LOS), intensive care length of stay, operative intervention, therapeutic interventions and outcomes were analyzed retrospectively. RESULTS: Twenty-eight of 4310 admissions were taking DE. Eleven patients were excluded on concurrent antiplatelet therapy. Average age was 77.14 years(64-94 years), and average LOS was 4.7 d(1-35 d). Thirty-two percent were admitted with intracranial hemorrhage. Eighteen percent received factor Ⅶ, and 22% received dialysis in attempts to correct coagulopathy. Mortality was 21%.CONCLUSION: The low incidence, absence of reversal agents, and lack of practice guidelines makes managing patients with TBI taking DE frustrating and provider specific. Local practice guidelines may be helpful in managing such patients. | Sam Pakraftar Daniela Atencio John English Alain Corcos Eric M Altschuler Kurt Stahlfeld | 2014 | World Journal of Clinical Cases2014，2，8： | 3 |
| 3 | Prosthetic above-knee femoropopliteal bypass grafting: Five-year results of a randomized trial显示文摘 | Richard M Green William M Abbott Teruo Matsumoto Jock R Wheeler Normand Miller Frank J Veith Sam Money H Edward Garrett | 2000 | Journal of Vascular Surgery2000，，： | 2 |
| 4 | Preliminary Studies into the Behaviour of Knee Braced Frames Subject to Seismic Loading显示文摘 | Sam M T Liaw C Y | 1991 | Engineering Structures1991，13，： | 1 |
| 5 | Co-firing of coal and biomass fuel blends显示文摘 | Sam M Annamalai K | 2001 | Progress in Energy and Combustion Science2001，27，： | 1 |
| 6 | A class of proportional in tegral sliding mode control with application to active suspension system显示文摘 | Sam Y M Osman H S Ghani M R | 2004 | Systems & Control Letters2004，51，3： | 1 |
| 7 | Human demography and reserve size predict wildlife extinction in West Africa显示文摘 | BRASHARES J S ARCESE P SAM M K | 2001 | Proceedings of the Royal Society of London Series B:Biological Sciences2001，268，： | 1 |
| 8 | Vaginalmotionandbladderandrectalvolumesduringpelvicintensity-modulatedradiationtherapyafterhysterectomy显示文摘 | JhingranA SalehourM Sam M etal | 2012 | IntJRadiatOncolBiolPhys2012，82，1： | 1 |
| 9 | Effect of radiation dose and adaptive sta- tistical iterative reconstruction on image quality of pulmonary computed tomography显示文摘 | Sam J Akahane M Inano S et 81 | 2012 | Jpn J Radiol2012，30，2： | 1 |
| 10 | Self cleaning photoactive TiO2 coatings on SLS glasses by sol-gel dip coating显示文摘 | Sam E D Urgen M Tepehan F Z Gunay V | 2004 | Key Engineering Materials2004，，： | 1 |
| 11 | The ralationship between the thrombotic and infectious complications of central venous catheters 显示文摘 | Raad II Luna M Khalil SAM | 1994 | JAMA1994，271，13： | 1 |
| 12 | Process monitoring based on classification tree and discriminant analysis显示文摘 | Zhou Yifeng Hahn Juergen Sam Mannan M | 2006 | Reliability Engineering & System Safety2006，91，5： | 1 |
| 13 | The measurement of velocity dispersion and frequency-dependent intrinsic attenuation in sedimentary rocks 显示文摘 | Sams M S Neep J P Worthington M H | 1997 | Geophysics1997，62，5： | 1 |
| 14 | The integration of Dow's fire and explosion index (F&EI) into process design and optimization to achieve inherently safer design显示文摘 | UARDIN J SAM MANNAN M MAHMOUD E | 2007 | Loss Prevention in the Process Industries2007，20，： | 1 |
| 15 | Movable bed roughness in alluvial rivers 显示文摘 | Wu W M Wang Sam S Y | 1999 | Journal of Hydraulic Engineering ASCE1999，125，12： | 1 |
| 16 | Toward a 3D marine cadastre in support of good ocean governance:a review of the technical framework requirements显示文摘 | Nganga Sam Sutherland M Cockburn Sara | 2004 | Computers Environment and Urban Systems2004，28，5： | 1 |
| 17 | Surum vitamin K1 concentrations after oral administration of vitamin K1 in low birth weight infants显示文摘 | Sam L Leeleroq M Sc B | 1985 | J Pediatr1985，106，5： | 1 |
| 18 | Coordinated expression of galectin‐3 and caveolin‐1 in thyroid cancer显示文摘 | Jay Shankar Sam M Wiseman Fanrui Meng Katayoon Kasaian Scott Strugnell Alireza Mofid Allen Gown Steven JM Jones Ivan R Nabi | 2012 | J Pathol2012，，1： | 1 |
| 19 | Effect of surface texturing on rolling contact fatigue within mixed lubricated non-conformal rolling/sliding contacts显示文摘 | Vrbka M Sam&aek O Sperka P | 2010 | Tribology International2010，43，8： | 1 |
| 20 | Dispersion modeling approach for quantification of methane emission rates from natural gas fugitive leaks detected by infrared imaging technique显示文摘 | Safitri Anisa Gao Xiaodan Mannan M Sam | 2011 | Jour- nal of Loss Prevention in the Process Industries2011，24，2： | 1 |
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