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| 1 | Lymph node imaging in initial staging of prostate cancer:An overview and update显示文摘Accurate nodal staging at the time of diagnosis of prostate cancer is crucial in determining a treatment plan for the patient.Pelvic lymph node dissection is the most reliable method,but is less than perfect and has increased morbidity.Cross sectional imaging with computed tomography(CT) and magnetic resonance imaging(MRI) are non-invasive tools that rely on morphologic characteristics such as shape and size of the lymph nodes.However,lymph nodes harboring metastatic disease may be normal sized and non-metastatic lymph nodes may be enlarged due to reactive hyperplasia.The optimal strategy for preoperative staging remains a topic of ongoing research.Advanced imaging techniques to assess lymph nodes in the setting of prostate cancer utilizing novel MRI contrast agents as well as positron emission tomography(PET) tracers have been developed and continue to be studied.Magnetic resonance lymphography utilizing ultra-small super paramagnetic iron oxide has shown promising results in detection of metastatic lymph nodes.Combining MRL with diffusion-weighted imaging may also improve accuracy.Considerable efforts are being made to develop effective PET radiotracers that are performed using hybrid-imaging systems that combine PET with CT or MRI.PET tracers that will be reviewed in this article include [^(18)F]fluoro-D-glucose,sodium [^(18)F]fluoride,[^(18)F]choline,[^(11)C]choline,prostate specific membrane antigen binding ligands,[^(11)C]acetate,[^(18)F]fluciclovine,gastrin releasing peptide receptor ligands,and androgen binding receptors.This article will review these advanced imaging modalities and ability to detect prostate cancer metastasis to lymph nodes.While more research isneeded,these novel techniques to image lymph nodes in the setting of prostate cancer show a promising future in improving initial lymph node staging. | Jessica G Zarzour Sam Galgano Jonathan McConathy John V Thomas Soroush Rais-Bahrami | 2017 | World Journal of Radiology2017，9，10： | 5 |
| 2 | Fecal lactoferrin accurately reflects mucosal inflammation in inflammatory bowel disease显示文摘BACKGROUND Studies have demonstrated a potential role for fecal biomarkers such as fecal calprotectin(FC)and fecal lactoferrin(FL)in monitoring inflammatory bowel diseases(IBD)-Crohn's disease(CD)and ulcerative colitis(UC).However,their correlation to endoscopic scores,disease severity and affected intestinal surface has not been extensively investigated.AIM To correlate FL,and for comparison white blood cell(WBC)and C-reactive protein(CRP),with endoscopic scores,disease extent and location in CD and UC.METHODS Retrospective analysis in 188 patients who had FL,CRP and WBC determined within 30 d of endoscopy.Disease location,disease extent(number of intestinal segments involved),disease severity(determined by endoscopic scores),timing of FL testing in relation to colonoscopy,as well as the use of effective fast acting medications(steroids and biologics)between colonoscopy and FL measurement,were recorded.RESULTS In 131 CD and 57 UC patients,both CRP and FL-but not WBC-distinguished disease severity(inactive,mild,moderate,severe).In patients receiving fastacting(steroids or biologics)treatment in between FL and colonoscopy,FL showed a higher correlation to endoscopic scores when tested before vs after the procedure(r=0.596,P<0.001,vs r=0.285,P=0.15 for the Simple Endoscopic Score for CD;and r=0.402,P=0.01 vs r=0.054 P=0.84 for Disease Activity Index).Finally,FL was significantly correlated with the diseased mucosal surface(colon-ileocolon>small bowel)and the number of inflamed colon segments.CONCLUSION FL and CRP separated disease severity categories with FL showing lower discriminating P-values.FL showed a close correlation with the involved mucosal surface and with disease extent and was more closely correlated to endoscopy when determined before the procedure–this indicating that inflammatory activity changes associated with therapy might be rapidly reflected by FL levels.FL can accurately and timely characterize intestinal inflammation in IBD. | Marrieth G Rubio Kofi Amo-Mensah James M Gray Vu Q Nguyen Sam Nakat Douglas Grider Kim Love James H Boone Dario Sorrentino | 2019 | World Journal of Gastrointestinal Pathophysiology2019，10，5： | 4 |
| 3 | Gbest-guided artificial bee colony algorithm for numerical function optimization 显示文摘 | Zhu G P Sam K | 2010 | Appl Math Comput2010，217，7： | 1 |
| 4 | Julocrotine, a glutarimide alkaloid from Croton membranaceus 显示文摘 | Aboagye FA Sam GH Massiot G | 2000 | FitoteraNa2000，71，： | 1 |
| 5 | Population pharmacokineties of remifentanil in infants and children undergoing cardiac surgery显示文摘 | SAM W J HAMMER G B DROVER D R | 2009 | BMC Anesthesiol2009，9，： | 1 |
| 6 | Conceptual Design and Analysis of Ferrari F430 Flying car 显示文摘 | Sams G D | 2012 | lnternational Journal of Research in Engineering and Technology2012，1，6： | 1 |
| 7 | Early results of a single-blinded, randomized, controlled, Internet-based multicenter trial comparing Prolene and Vypro?II mesh in Lichtenstein hernioplasty显示文摘 | Sven Bringman Timo-Jaakko Heikkinen Staffan Wollert Johanna ?sterberg Sam Smedberg H?kan Granlund Stig Ramel G?ran Fell?nder Bo Anderberg | 2004 | Hernia2004，，2： | 1 |
| 8 | Fracture strengths of provisional restorations reinforced with plasms treated woven polyethylene fiber显示文摘 | Sam adzadeh A Kugel G Hurley E | 2000 | J Prothet Dent2000，81，4： | 1 |
| 9 | Myocardial infarction in young a- dults:Risk factots and clinical features显示文摘 | Mark G Sam J Jeffreg S | 1996 | J N Engl Med1996，14，： | 1 |
| 10 | Isolation and characterization of the promoter of the human prostate cancer- specific DD3 gene显示文摘 | Verhaegh G W van Bokhoven A Sam it F | 2000 | J Biol Chem2000，275，37： | 1 |
| 11 | Power consumption measurements for ac and pulsed dc for electrostatic coal lescence of water-in-oil emulsions 显示文摘 | Lee C M Sams G W Wagner J P | 2004 | Journal of Electrostatics2004，53，1： | 1 |
| 12 | Long-term neurocognitive effects of antipsychotics in schizophrenia:A network meta-analysis显示文摘 | Désaméricq G Schurhoff F Meary A | 2014 | European Journal of Pharmacology2014，70，： | 1 |
| 13 | Myocardial infarction in young aduhs : risk factors and features显示文摘 | Mark G Sam J Jefery S | 1996 | EmeN Med1996，14，： | 1 |
| 14 | Myocardial infarction in young adults: Risk factors and clinical features显示文摘 | MARK G SAM J JEFFEREY S | 1996 | The Journal of Emergency Medicine1996，14，： | 1 |
| 15 | Practical implementation of a neural network controller in a hard disk drive显示文摘 | Herrmann G Ge Shuzhi Sam Guo Guoxiao | 2005 | IEEE Trans on Control Systems Technology2005，13，1： | 1 |
| 16 | Identification of two lipid binding proteins from liver Of Gallus domestieus 显示文摘 | Sams G H Hargis B M Hargis P S | 1991 | Comp Biochem Physiol B1991，99，1： | 1 |
| 17 | Musicians have enhanced subcortical auditory and audiovisual processing of speech and music显示文摘 | MUSACCHIA G SAMS M SKOE E | 2007 | Proc Nail Acad Sci USA2007，104，15： | 1 |
| 18 | Flow cytometric measurement of circulating endothelial cells:the effect of age and peripheral arterial disease on baseline levels of mature and progenitor populations 显示文摘 | Rebecca S Sam G Arash A | 2006 | Cytometry PartB (Clinical Cytometry )2006，70，2： | 1 |
| 19 | Clinical evaluation of autolQgous platelet rich fibrin in horizontal alveolar bony defects显示文摘 | Joseph VR Sam G Amol NV | 2014 | J Clin Diagn Res2014，8，11： | 1 |
| 20 | GEM: Using Metadata to En- hance Internet Retrieval by K-12 Teachers显示文摘 | Sutton Stuart A Oh Sam G | 1997 | Bulletin of the American Society for Information Science & Technolo- gy1997，，1： | 1 |
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