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| 1 | Streptococcus mutans activates the AIM2, NLRP3 and NLRC4 inflammasomes in human THP-1 macrophages显示文摘Streptococcus mutans(S. mutans), a major aetiologic agent of dental caries, is involved in systemic diseases, such as bacterial endocarditis, if it enters the bloodstream through temporary bacteraemia. Interleukin(IL)-1β, a proinflammatory cytokine, is related to the host defences against pathogens, and its synthesis, maturation, and secretion are tightly regulated by the activation of the inflammasome, an inflammatory signalling complex. This study examined the signalling mechanism of IL-1β secretion and the inflammasome pathway induced by S. mutans to explain the molecular mechanism through which systemic infection by oral streptococci can occur. After infection of THP-1 cells with S. mutans, the expression of inflammasome components was detected using various methods. S. mutans induced IL-1β secretion via caspase-1 activation, and S. mutans-induced IL-1β secretion required absent in melanoma(AIM2), NLR family pyrin domain-containing 3(NLRP3) and NLR family CARD domain-containing 4(NLRC4)inflammasome activation. In particular, the S. mutans-induced NLRP3 inflammasome was mediated by adenosine triphosphate(ATP) release, potassium depletion and lysosomal damage. Our study provides novel insight into the innate immune response against S. mutans infection. | Yuri Song Hee Sam Na Eunjoo Park Mi Hee Park Hyun Ah Lee Jin Chung | 2018 | International Journal of Oral Science2018，10，3： | 6 |
| 2 | Selective ablation of peptide YY ceils in adult mice reveals their role in beta cell survival显示文摘 | Sam AH Gunner DJ King A | 2012 | Gastroenterology2012，143，2： | 1 |
| 3 | Chlorogenic acid, an antioxidant principle from the aerial parts of Artemisia iwayomogi that acts on 1,1-diphenyl-2-picrylhydrazyl radical显示文摘 | Soon Shin Kim Chung Kyu Lee Sam Sik Kang Hyun Ah Jung Jae Sue Choi | 1997 | Archives of Pharmacal Research1997，，： | 1 |
| 4 | The role of the guComin axis in modulating food intake显示文摘 | Sam AH Troke RC Tan TM | 2012 | Neuropharmacology2012，63，1： | 1 |
| 5 | The role of the gut/brain axis inmodulating food intake 显示文摘 | Sam AH Troke RC Tan TM | 2012 | Neuropharmacology2012，63，1： | 1 |
| 6 | coli strain causing an outbreak of hemolytic-uremic syndrome in Ger many 显示文摘 | Rasko DA Webster DR SaM UW et ah Origins of the E | 2011 | NEng[J Med2011，365，8： | 1 |
| 7 | The role of the gut/brain axis in modulating food intake 显示文摘 | Sam AH Troke RC Tan TM | 2012 | Neuropharmacology2012，63，1： | 1 |
| 8 | Banisteriopsiscaapi,a unique com bination of M A O inhibitory andantioxidative constituents for the activities relevant toneurodegenerative disorders and Parkinson s disease显示文摘 | Sam oylenko V R ah m an M T ekw ani h h e t a l | | JE thnopharm acol0，127，： | 1 |
| 9 | The role of the gut/brain axis in modulating food intake 显示文摘 | Sam AH Trnke RC Tan TM | 2012 | Neuropharmacology2012，63，1： | 1 |
| 10 | Cholinesterase and BACE1 inhibitory diterpenoids from Aralia cordata显示文摘 | Hyun Ah Jung Eun Ju Lee Ju Sun Kim Sam Sik Kang Je-Hyun Lee Byung-Sun Min Jae Sue Choi | 2009 | Archives of Pharmacal Research2009，，10： | 1 |
| 11 | Anti-inflammatory activity of the constituents of the roots of Aralia continentalis显示文摘 | Hyun Lim Hyun Ah Jung Jae Sue Choi Yeong Shik Kim Sam Sik Kang Hyun Pyo Kim | 2009 | Archives of Pharmacal Research2009，，9： | 1 |
| 12 | Antioxidant constituents and a new triterpenoid glycoside from Flos Lonieerae显示文摘 | Chtm-Whan Choi Hyun Ah Jung Sam Sik Kang | 2007 | Arch Pharm Res2007，30，1： | 1 |
| 13 | The role of the gut/ brain axis in modulating food intake显示文摘 | Sam AH Troke RC Tan TM | 2012 | Neuropharmacolo- gy2012，63，1： | 1 |
| 14 | Kisspeptin: A critical regulator of puberty and re- productive function 显示文摘 | Sam AH Dhillo WS | 2010 | Curr Drug Targets2010，11，8： | 1 |
| 15 | Serum phosphate predicts temporary hypocalcaemia following thyroidectomy 显示文摘 | Sam AH Dhillo WS Donaldson M | | Clin Endocrinol( Oxf)0，74，3： | 1 |
| 16 | Hyperoside prevents oxidative damage induced by hydrogen peroxide in lung fibroblast cells via an antioxidant effect显示文摘 | Mei Jing Piao Kyoung Ah Kang Rui Zhang Dong Ok Ko Zhi Hong Wang Ho Jin You Hee Sun Kim Ju Sun Kim Sam Sik Kang Jin Won Hyun | 2008 | BBA - General Subjects2008，，： | 1 |
| 17 | The role of the gut/brain axis in modulating food intake显示文摘 | Sam AH Troke RC Tan TM | 2012 | Neuropharmacology2012，63，1： | 1 |
| 18 | Lamanna Hypoxia-induced brain angiogenesis in the adult rat显示文摘 | Sam I Martin AH Joseph C | 1995 | Journal of Physiology1995，85，2： | 1 |
| 19 | Gastroscopic observations of the effect of aspirin, and certain other substances on the stomach 显示文摘 | Douthwaite AH Lintott SAM | 1938 | Lancet1938，2，： | 1 |
| 20 | Anti-inflammatory effects of glycyrol isolated from Glycyrrhiza uralensis in LPS-stimulated RAW264.7 macrophages显示文摘 | Eun Myoung Shin Hong Yu Zhou Lian Yu Guo Jeong Ah Kim Seung Ho Lee Irmgard Merfort Sam Sik Kang Hak Sung Kim Sanghee Kim Yeong Shik Kim | 2008 | International Immunopharmacology2008，，11： | 1 |
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