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| 1 | New findings showing how DNA methylation influences diseases显示文摘In 1975, Holliday and Pugh as well as Riggs independently hypothesized that DNA methylation in eukaryotes could act as a hereditary regulation mechanism that influences gene expression and cell differentiation. Interest in the study of epigenetic processes has been inspired by their reversibility as well as their potentially preventable or treatable consequences. Recently, we have begun to understand that the features of DNA methylation are not the same for all cells.Major differences have been found between differentiated cells and stem cells.Methylation influences various pathologies, and it is very important to improve the understanding of the pathogenic mechanisms. Epigenetic modifications may take place throughout life and have been related to cancer, brain aging, memory disturbances, changes in synaptic plasticity, and neurodegenerative diseases,such as Parkinson's disease and Huntington's disease. DNA methylation also has a very important role in tumor biology. Many oncogenes are activated by mutations in carcinogenesis. However, many genes with tumor-suppressor functions are 'silenced' by the methylation of CpG sites in some of their regions.Moreover, the role of epigenetic alterations has been demonstrated in neurological diseases. In neuronal precursors, many genes associated with development and differentiation are silenced by CpG methylation. In addition,recent studies show that DNA methylation can also influence diseases that do not appear to be related to the environment, such as IgA nephropathy, thus affecting,the expression of some genes involved in the T-cell receptor signaling. In conclusion, DNA methylation provides a whole series of fundamental information for the cell to regulate gene expression, including how and when the genes are read, and it does not depend on the DNA sequence. | Fabio Sallustio Loreto Gesualdo Anna Gallone | 2019 | World Journal of Biological Chemistry2019，10，1： | 2 |
| 2 | Cytotoxin-associated Gene-A-positive Helicobacter pylori strains infection increases the risk of recurrent atherosclerotic stroke 显示文摘 | DIOMEDI M STANZIONE P SALLUSTIO F | 2008 | Helicobacter2008，13，6： | 1 |
| 3 | Abnormal rniR-148b expression promotes aberrant glycosylation of IgA1 in IgA nephropathy显示文摘 | Serino G Sallustio F Cox SN | 2012 | J Am Soe Nephrol2012，23，5： | 1 |
| 4 | Transcranial direct current stimulation of the affected hemisphere does not accelerate recovery of acute stroke patients 显示文摘 | Rossi C Sallustio F Di Legge S | 2013 | Eur J Neurol2013，20，1： | 1 |
| 5 | Cochlear function in ears with immunomediated inner ear disorder 显示文摘 | Quaranta A Scaringi A Sallustio V | 2002 | Acta Otolaryngol Suppl2002，，548： | 1 |
| 6 | Changes in cere-brova-scular reactivity following low- frequency repetitivetranscranialmagnetic stimulation显示文摘 | Sallustio F Di Legge S Rizzato B | 2010 | J Neurol Sci2010，295，12： | 1 |
| 7 | In vivo covalent binding of clofibric acid to human plasma proteins and rat liver proteins 显示文摘 | SALLUSTIO B C KNIGHTS K M ROBERTS B J | 1991 | Biochem Pharm1991，42，： | 1 |
| 8 | Assessment of intracranial collateral flow by using dynamic arterial spin labeling MRA and transcranial color-coded duplex ultrasound显示文摘 | Sallustio F Kern R Ganther M | 2008 | Stroke2008，39，6： | 1 |
| 9 | Diagnostic imaging of primitive neuroectodermal tumour of the chest wall (Askin tumour) 显示文摘 | Sallustio G Pirronti T Lasorella A | 1998 | Pediatr Radiol1998，28，： | 1 |
| 10 | Transcranial di- rect current stimulation of the affected hemisphere does not accelerate recovery of acute stroke patients显示文摘 | Rossi C Sallustio F Di Legge S | 2013 | Eur J Neurol2013，20，1： | 1 |
| 11 | Concomitant boost radiotherapy and multidrug chemotherapy in the neoadjuvant treatment of locally advanced rectal cancer: Results of a phase II study显示文摘 | Luciana Caravatta Gilbert D. A. Padula Vincenzo Picardi Gabriella Macchia Francesco Deodato Mariangela Massaccesi Luigi Sofo Fabio Pacelli Fabio Rotondi Giuseppe Cecere Giuseppina Sallustio Liberato Di Lullo Adele Piscopo Samantha Mignogna Pierluigi Bonom | 2011 | Acta Oncologica2011，，8： | 1 |
| 12 | Assessment collateral flow by using dynamic arterial spin labeling MRA and transcranial color-coded duplex ultrasound显示文摘 | Sallustio F Kern of intracranial R G unther M | 2008 | Stroke2008，39，6： | 1 |
| 13 | Frequency of hu- man papillomavirus infection and genotype distribution a- mong women with known cytological diagnosis in a South- ern Italian region显示文摘 | Chironna M Neve A Sallustio A | 2010 | J Prey Med Hyg2010，51，4： | 1 |
| 14 | Impact of either elevated or decreased levels of cytochrome expression on Shigella flexneri virulence显示文摘 | Way SS Sallustio S Magliozzo RS | 1999 | J Bacteriol1999，181，1： | 1 |
| 15 | Diagnostic imaging of primitive neuroectodermal tumor of the chest wall (Askin tumor)显示文摘 | Pirronti T Lasorella A | 1998 | Pediatr Radiol1998，28，： | 1 |
| 16 | Evaluation of the 'N' factor in non-small cell lung cancer: correlation between computerized tomography and pathologic anatomy 显示文摘 | Pirronti T Macis G Sallustio G | 2000 | Radiol Med2000，99，5： | 1 |
| 17 | Frequency of human pap illomavirus infection and genotype distribution among women with known cytological diagnosis in a Southern Italian region显示文摘 | Chironna M Neve A Sallustio A | 2010 | Prev Med Hyg2010，51，4： | 1 |
| 18 | MicroRNAs in kidney diseases:new promising biomarkers for diagnosis and monitoring 显示文摘 | Schena FP Serino G Sallustio F | 2014 | NephrolDial Transplant2014，29，4： | 1 |
| 19 | Abnormal miR-148b expression promotes aberrant glycosylation of IgA1 in IgA nephropathy显示文摘 | Serino G Sallustio F Cox SN | 2012 | J Am Soc Nephrol2012，23，5： | 1 |
| 20 | Long-term outcome of Meniere's disease : endolymphatic mastoid shunt versus natural history 显示文摘 | Quaranta A Marini F Sallustio V | 1998 | Audiol Neurootol1998，3，1： | 1 |
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