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| 1 | Neuroprotective effects of minocycline on focal cerebral ischemia injury: a systematic review显示文摘To review the neuroprotective effects of minocycline in focal cerebral ischemia in animal models.By searching in the databases of PubMed,ScienceDirect,and Scopus,and considering the inclusion and exclusion criteria of the study.Studies were included if focal cerebral ischemia model was performed in mammals and including a control group that has been compared with a minocycline group.Written in languages other than English;duplicate data;in vitro studies and combination of minocycline with other neuroprotective agents were excluded.Neurological function of patients was assessed by National Institute of Health Stroke Scale,modified Rankin Scale,and modified Barthel Index.Neuroprotective effects were assessed by detecting the expression of inflammatory cytokines.We examined 35 papers concerning the protective effects of minocycline in focal cerebral ischemia in animal models and 6 clinical trials which had evaluated the neuroprotective effects of minocycline in ischemic stroke.These studies revealed that minocycline increases the viability of neurons and decreases the infarct volume following cerebral ischemia.The mechanisms that were reported in these studies included anti-inflammatory,antioxidant,as well as anti-apoptotic effects.Minocycline also increases the neuronal regeneration following cerebral ischemia.Minocycline has considerable neuroprotective effects against cerebral ischemia-induced neuronal damages.However,larger clinical trials may be required before using minocycline as a neuroprotective drug in ischemic stroke. | Yazdan Naderi Yunes Panahi George E. Barreto Amirhosein Sahebkar | 2020 | Neural Regeneration Research2020，15，5： | 10 |
| 2 | Efficacy and safety of Aloe vera syrup for the treatment of gastroesophageal reflux disease: a pilot randomized positive-controlled trial显示文摘OBJECTIVE: To investigate the use of Aloe vera(A.vera) for the treatment of gastroesophageal reflux disease(GERD) symptoms and compare its effects with those of omeprazole and ranitidine.METHODS: In this pilot, randomized controlled trial, 79 subjects were allocated to A. vera syrup(standardized to 5.0 mg polysaccharide per m L of syrup)at a dose of 10 m L/d, omeprazole capsule(20 g/d)or ranitidine tablet(150 mg in a fasted state in the morning and 150 mg 30 min before sleep at night)for a period of 4 weeks. The frequencies of eight main symptoms of GERD(heartburn, food regurgitation, flatulence, belching, dysphagia, nausea,vomiting and acid regurgitation) were assessed at weeks 2 and 4 of the trial.RESULTS: A. vera was safe and well tolerated and reduced the frequencies of all the assessed GERD symptoms, with no adverse events requiring withdrawal.CONCLUSION: A. vera may provide a safe and effective treatment for reducing the symptoms of GERD. | Yunes Panahi Hossein Khedmat Ghasem Valizadegan Reza Mohtashami Amirhossein Sahebkar | 2015 | Journal of Traditional Chinese Medicine2015，35，6： | 5 |
| 3 | Potential efficacy of ginger as a natural supplement for nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD) is one of the most common liver diseases and its prevalence is likely to reach epidemic proportions.According to the'two-stage hypothesis'proposed for the pathophysiology of NAFLD,insulin resistance,oxidative stress and pro-inflammatory cytokines are among the key promoters of the disease. Here,ginger has been hypothesized to prevent NAFLD or blunt its progression via several mechanisms,such as sensitizing insulin effects,activating peroxisome proliferator-activated receptorγwhich induces adiponectin and down-regulates pro-inflammatory cytokines,changing the balance between adiponectin and tumor necrosis factor-αin favor of adiponectin,promoting considerable antioxidant effects and antidyslipidemic properties,and reducing hepatic triglyceride content which can prevent steatosis.The aforementioned mechanisms imply that ginger possesses interesting potentials for serving as a natural supplement for the prevention and treatment of NAFLD.Therefore,conducting trials to explore its benefits in clinical practice is greatly recommended. | Amirhossein Sahebkar | 2011 | World Journal of Gastroenterology2011，17，2： | 4 |
| 4 | Therapeutic potential of trehalose in neurodegenerative diseases:the knowns and unknowns显示文摘Neurodegenerative diseases(NDs)are a growing health problem associated with a high burden due to destructive and longterm clinical effects.Cellular aggregations of misfolded proteins are the most common pathological hallmark of many late-onset NDs called proteinopathies including Parkinson’s disease(PD),Alzheimer’s disease(AD),tauopathies,amyotrophic lateral sclerosis(ALS),and polyglutamine(polyQ)expansion diseases such as Huntington’s disease(HD)and various spinocerebellar ataxias(SCA)such as SCA3(Renna et al.,2010).Misfolded proteins can be generated by posttranslational conjugation(e.g.,hyperphosphorylated tau in AD),or endoproteolytic cleavage(e.g.,amyloidβpeptides)or genetic mutations in specific proteins(such as HTT in HD,α-synuclein in PD,PrPC in prion disease and SOD1 and TDP-43 in ALS)leading to the formation of oligomers. | Masoomeh Khalifeh George E.Barreto Amirhossein Sahebkar | 2021 | Neural Regeneration Research2021，16，10： | 2 |
| 5 | Investigation of the Lipid-Modifying and Antiinflammatory Effects of Cornus mas L. Supplementation on Dyslipidemic Children and Adolescents显示文摘 | Sedigheh Asgary Roya Kelishadi Mahmuod Rafieian-Kopaei Somayeh Najafi Mitra Najafi Amirhossein Sahebkar | 2013 | Pediatric Cardiology2013，，7： | 2 |
| 6 | An Investigation of the Effects of Curcumin on Anxiety and Depression in Obese Individuals:A Randomized Controlled Trial显示文摘Objective:To investigate the effectiveness of curcumin,a natural polyphenoiic compound with antioxidant and anti-inflammatory activities,on the frequency of symptoms of anxiety and depression in obese individuals.Methods:In this double blind,cross-over trial,30 obese subjects were randomized to receive either curcumin(1 g/day) or placebo for a period of 30 days.Following a wash-out interval of 2 weeks,each subject was crossed over to the alternative regimen for a further 30 days.Severity of anxiety and depression was assessed at baseline and at weeks 4,6 and 10 of the trial using the Beck Anxiety Inventory(BAI) and Beck Depression Inventory(BDI) scales,respectively.Results:Mean BAI score was found to be significantly reduced following curcumin therapy(P=0.03).However,curcumin supplementation did not exert any significant impact on BDI scores(P=0.7).Conclusion:Curcumin has a potential anti-anxiety effect in individuals with obesity. | Habibollah Esmaily Amirhossein Sahebkar Mehrdad Iranshahi Shiva Ganjali Akram Mohammadi Gordon Ferns Majid Ghayour-Mobarhan | 2015 | Chinese Journal of Integrative Medicine2015，21，5： | 2 |
| 7 | Phytochemicals as inhibitors of tumor necrosis factor alpha and neuroinflammatory responses in neurodegenerative diseases显示文摘Inflammatory processes and proinflammatory cytokines have a key role in the cellular processes of neurodegenerative diseases and are linked to the pathogenesis of functional and mental health disorders.Tumor necrosis factor alpha has been reported to play a major role in the central nervous system in Alzheimer’s disease,Parkinson’s disease and amyotrophic lateral sclerosis and many other neurodegenerative diseases.Therefore,a potent proinflammatory/proapoptotic tumor necrosis factor alpha could be a strong candidate for targeted therapy.Plant derivatives have now become promising candidates as therapeutic agents because of their antioxidant and chemical characteristics,and anti-inflammatory features.Recently,phytochemicals including flavonoids,terpenoids,alkaloids,and lignans have generated interest as tumor necrosis factor alpha inhibitor candidates for a number of diseases involving inflammation within the nervous system.In this review,we discuss how phytochemicals as tumor necrosis factor alpha inhibitors are a therapeutic strategy targeting neurodegeneration. | Fatemeh Zahedipour Seyede Atefe Hosseini Neil C.Henney George E.Barreto Amirhossein Sahebkar | 2022 | Neural Regeneration Research2022，17，8： | 2 |
| 8 | Effect of ginger on acute and delayed chemotherapy-induced nausea and vomiting: a pilot, randomized, open-label clinical trial 显示文摘 | Panahi Y Saadat A Sahebkar A | 2012 | Integr Cancer Ther2012，11，3： | 1 |
| 9 | A systematic review and meta-analysis of randomized controlled trials investigating the effects of curcumin on blood lipid levels显示文摘 | Amirhossein Sahebkar | 2014 | Clinical Nutrition2014，，3： | 1 |
| 10 | Changes in Plasma Level of Heat Shock Protein 27 After Acute Coronary Syn- drome 显示文摘 | Heidari - Bakavoli AR Sahebkar A Mobara N | 2012 | Angiology2012，63，1： | 1 |
| 11 | Effect of statin therapy on plasma PCSK9 concentrations: A systematic review and meta- analysis of clinical trials 显示文摘 | Sahebkar A Simental- Mendia LE Guerrero- Romero F | 2015 | Diabetes Obes Metab2015，17，11： | 1 |
| 12 | Sesquiterpene coumarins from the fruits of Ferula badrakema 显示文摘 | IRANSHAHI M REZAEE R SAHEBKAR A | 2009 | Pharmaceutical Biology2009，47，4： | 1 |
| 13 | Sleep chan- ges following statin therapy: a systematic review and meta-a- nalysis of randomized placebo-controlled polysomnographic tri- als显示文摘 | Broncel M Gorzelak-Pabis P Sahebkar A | 2015 | Archives of Medical Science2015，11，5： | 1 |
| 14 | Nonlinear vibration analysis of an axially moving drillstring system with time dependent axial load and axial velocity in inclined well显示文摘 | S.M. Sahebkar M.R. Ghazavi S.E. Khadem M.H. Ghayesh | 2010 | Mechanism and Machine Theory2010，，5： | 1 |
| 15 | Proprotein convertase subtilisin/kexin type 9: a plausible link between serum resistin levels and cardiovascular events显示文摘 | Sahebkar A | 2015 | Angiology2015，65，3： | 1 |
| 16 | Observation on physi-cal growth of nonmetallic inclusion in liquid steel during ladletreatment显示文摘 | Kang Y J Sahebkar B Scheller P R | 2011 | Metallurgical and Materials Transactions: B2011，42，3： | 1 |
| 17 | Lack of efficacy of resveratrol on C-reactive protein and selected cardiovascular risk factors-Results from a systematic review and meta-analysis of randomized controlled trials显示文摘 | Sahebkar A Serban C Ursoniu S | 2015 | Int J Cardiol2015，，189： | 1 |
| 18 | New peroxisome proliferator-ae- tivated receptor agonists : potential treatments for atherogenie dys- lipidemia and non-alcoholic fatty liver disease 显示文摘 | Sahebkar A Chew GT Watts GF | 2014 | Expert Opin Pharmacother2014，15，4： | 1 |
| 19 | Analysis of vitamin D levels in patients with and without statin-associated myalgia-A systematic review and Meta-analysis of 7 studies with 2420 patients显示文摘 | Michalska-Kasiczak M Sahebkar A Mikhailidis DE | 2015 | IntJ Cardiol2015，178，： | 1 |
| 20 | Effects of Coenzyme Q10 on statin-induced myopathy: a meta- analysis of randomized controlled trials显示文摘 | Banach M 8erban C Sahebkar A | 2015 | Mayo Clinic Proc2015，90，1： | 1 |
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