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| 1 | Analgesic,anti-inflammatory and anti-diarrheal activities of ethanolic leaf extract of Typhonium trilobatum L.Schott显示文摘Objective:To explore the efficacy of ethanolic leaf extract of Typhonium trilobatum L.Schott in treating diarrhea,pain and inflammation using experimental models.Methods:In the present study,acetic acid-induced writhing,xylene-induced ear edema and castor oil-imluced diarrlieal model were used to evaluate the analgesic,anti-inflammatory and anti-diarrheal activities,respectively.Acute toxicity test was carried out to fix the safe doses of the plant extract.Results:The plant extract demonstrated a significant inhibition of writhing(P<0.01)compared with the control group in acetic acid-induced writhing test in mice.The extract also significantly inhibited the xylene induced ear edema formation(P<0.05).In anti-diarrheal test,the extract significantly decreased the frequency of defecation and increased the mean latent period(P<0.0l)in castor oil-induced diarrheal model mice at the doses of 250 and 500 mg/kg body weight.Conclusions:These results suggest that the extract possesses significant analgesic,anti-inflammatory and anti-diarrheal activities that support to the ethnopharmacologicl uses of this plant. | Khadem Ali Ayesha Ashraf Nripendra Nath Biswas | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，9： | 6 |
| 2 | The effects of biochar on soil nutrients status,microbial activity and carbon sequestration potential in two calcareous soils显示文摘Biochar as an organic amendment improves soil attributes,with a potentially significant effect on soil chemical fertility and quality.The main objective of this study was to quantify the effect of biochar addition on nutrients,carbon sequestra-tion and microbial activity and understand the mechanisms of controlling biochar effects in calcareous soils.Maize residue biochars produced at 200,400 and 600℃ were added at 5 and 10 g kg^(−1)rates to sandy loam and clayey texture calcareous soils.The soil properties measured were pH and electrical conductivity(EC),plant-available potassium(K)and available phosphorus(P),total nitrogen(TN),C sequestration;and the fluorescein diacetate(FDA)hydrolysis activity.Addition of raw material and biochars increased pH(0.15-0.46 units),EC(0.14-0.38 dS m^(−1)),TN(63-120%),K(12-41%)and FDA activity(27-280%),but tended to decrease plant-available P(23-86%).Increasing pyrolysis temperature increased soil C pool index(CPI),but decreased the FDA and the changes depended largely upon the application rate and soil texture.The positive effects of biochar addition and its pyrolysis temperature on soil C sequestration potential were more pronounced at high than low application rate and in sandy loam than clayey soils.Nevertheless,the effect of biochar addition and pyrolysis temperature on the FDA activity was higher at high than low application rates,but lower in sandy loam than clayey soils.Although biochar application may successfully improve soil processes and attributes and have a high potential for C seques-tration,its effects are controlled by soil texture,pyrolysis temperature and application rate. | Allahyar Khadem Fayez Raiesi Hossein Besharati Mohammad Ali Khalaj | 2021 | Biochar2021，3，1： | 4 |
| 3 | Effect of vitamin E on oxidative stress status in small intestine of diabetic rat显示文摘AIM:To investigate the effect of vitamin E on oxidative stress status in the small intestine of diabetic rats. METHODS:Twenty-four male Wistar rats were randomly divided into three groups:Control (C),non-treated diabetic (NTD) and vitamin E-treated diabetic (VETD) groups. The increases in lipid peroxidation,protein oxidation and superoxide dismutase (SOD) in these three groups was compared after 6 wk. RESULTS:There was no significant difference in catalase activity between NTD and control rats. Compared to NTD rats,the treatment with vitamin E significantly decreased lipid peroxidation and protein oxidation,and also increased catalase activity and SOD. CONCLUSION:The results revealed the occurrence of oxidative stress in the small intestine of diabetic rats. Vitamin E,as an antioxidant,attenuates lipid peroxidation and protein oxidation,and increases antioxidant defense mechanism. | A Shirpoor MH Khadem Ansari S Salami F Ghaderi Pakdel Y Rasmi | 2007 | World Journal of Gastroenterology2007，13，32： | 4 |
| 4 | Antioxidant,antimicrobial,cytotoxic and analgesic activities of ethanolic extract of Mentha arvensis L.显示文摘Objective:To investigate potential antioxidant,antimicrobial,cytotoxic and analgesic activities of ethanolic extract of Mentha arrensis l.,in different in vivo and in vitro experimental models.Methods:In vitro DPPH radical scavenging assay was used to evaluate the antioxidant activity of the plant extract.In vivo analgesic activity was carried out by acetic acid—induced writhing test in Swiss albino mice.All studies in mice were undertaken at the doses of 250 and 500 mg/kg body weight.Antibacterial activilv was studied by disk diffusion assay against some Gram—positive and Gram—negative bacterial strains.Brine shrimp lethality assay was used to investigate cyloloxicity effects of the plant extract.Results:The extract showed free radical scavenging activity in the DPPH assay(IC5041 μg/mL)compared to the standard antioxidant ascorbic acid(IC5019 μg/mL).The extract also produced prominent antimicrobial activity against Salmonella typhi.Salmonella paratyphi.Shigella boydii,Streptococcus pyogenes and Streptococcus aureus compared to standard drug kanamycin at the dose of 30 μg/disc.The extract exhibited lethality against the brine shrimp nauplii with the LC50,values of 40 μg/mL.and also 90%mortality(LC90) value was found to be 160 μg/mL.In analgesic test.the extract demonstrated statistically significant(P<0.01) analgesic effect in acetic acid induced writhing in white albino mice al both dose levels.Conclusions:These results suggest that the ethanolic extract of Mentha arvenns L.has potential antioxidant,antibacterial,cytotoxic and analgesic activities that support the ethnopharmacological uses of this plant. | Nripendra Nath Biswas Subarna Saha Mohammed khadem Ali | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，10： | 2 |
| 5 | Protective Effects of Vitamin E on Diabetes-induced Oxidative Stress Status and Homocysteine in the Rat Heart显示文摘 | Mojtaba Beyramzadeh Mohammad Hassan Khadem Ansari Kaveh Azimzadeh Siamak Salami | 2017 | Journal of Pharmacy and Pharmacology2017，5，10： | 2 |
| 6 | Short-term effects of maize residue biochar on kinetic and thermodynamic parameters of soil β-glucosidase显示文摘Soil β-glucosidase (BG), the rate-limiting enzyme in the final step of cellulose hydrolysis, plays a key role in microbial metabolism, carbon (C) cycling and sequestration in terrestrial ecosystems. Biochar application is known to affect soil BG activity;however, most of the biochar studies have focused on the potential activity of BG, and it is not clear how biochar influences the kinetic and thermodynamic behavior of BG in the soil. The objective of this study was to investigate the effect of maize residue biochar on soil BG kinetic and thermodynamic parameters. Soil BG kinetic (V_(max) and K_(m)) and ther-modynamic (E_(a), ΔH_(a) and Q_(10)) parameters were determined within soils (clayey and sandy loam soils) amended with either maize residue (as positive control) or its biochar (600℃) at 0.5 and 1.0% ratios (w/w), and the mixtures were incubated for 90 days. BG showed an increase in potential enzymatic activity (81%), enzyme concentration (higher V_(max) value) (25%) and substrate affinity (lower K_(m) value) (32%) in the biochar-amended sandy loam soil only at high addition rates compared with the control, and an increase by about 86% of the catalytic efficiency (V_(max)/K_(m)). In the clayey soil, biochar addition decreased potential BG activity (by 10-29%), increased the V_(max) value (by 20-25%) and had no impact on enzyme-substrate binding affinity, but still increased the catalytic efficiency by 47-72%. Adsorption of soil BG by biochar particles did not affect the catalytic efficiency in the soil. Generally, application of maize residue biochar to the soil decreased the E_(a), ΔH_(a) and Q_(10) values of BG compared with the negative controls at both biochar rates in the light-textured soil and only at low biochar rate in heavy-textured soil. The direction and magnitude of BG responses (activity, kinetics, and thermodynamics) to biochar were more related to the soil characteristics. Biochar would increase soil BG thermal stability and decrease its sensitivity to increasing temperature and global warming. | Fayez Raiesi Allahyar Khadem | 2019 | Biochar2019，1，2： | 2 |
| 7 | Development of vibration signature analysis using multiwavelets systerns显示文摘 | KHADEM S E REZAEE M | 2003 | Journal of Sound and Vibration2003，，261： | 1 |
| 8 | Pulsating aerosols for drug delivery to the sinuses in healthy volunteers显示文摘 | MOLLER W SCHUSCHNIG U KHADEM SABA G | 2010 | Otolaryngol Head Neck Surg2010，142，： | 1 |
| 9 | Numerical Simulation of Roughness Effects on Flow and Heat Transfer in Microchannels at Slip Flow Regime显示文摘 | Khadem M H Shams M Hossainpour S | 2009 | International Communications in Heat and Mass Transfer2009，36，1： | 1 |
| 10 | Subclavian steal followin gleft subclavian artery occlusion during thoracic endovascular aortic repair:Doppler findings and literature review显示文摘 | Gulati M Khadem N Lekht I | 2015 | J Ultrasound Med2015，34，5： | 1 |
| 11 | Theoretical development and closed-form solution of nonlinear vibrations of a directly excited nanotube-reinforced composite cantilevered beam 显示文摘 | Mahmoodi N S Khadem S E Jalili N | 2006 | Archive of Applied Mechanics2006，75，： | 1 |
| 12 | Plasma brain natri- uretic peptide (BNP) as an indicator of left ventricular Function, early outcome and mechanical complications after acute myocardial infarc- tion显示文摘 | Fazlinezhad Khadem Rezaeian Yousefzadeh | 2011 | Clin Med Insights Cardiol2011，5，： | 1 |
| 13 | Is there a role for statins in a trial fibrillation显示文摘 | Ariyarajah V Dawe DE Khadem A | | 0，，08： | 1 |
| 14 | Distribu- tional assumptions in voxel-based morphometry显示文摘 | Salmond C H Ashburner J Vargha Khadem F | 2002 | Neuroim- age2002，17，2： | 1 |
| 15 | Distribution of Be,Al,Se and Bi in the surface waters of the western North Atlantic and Caribbean显示文摘 | Measures C I Grant B Khadem M | 1984 | Earth and Planetary Science Letters1984，71，： | 1 |
| 16 | A modification of the B runt system for scoring Iiver histology of patients with non-alco- holic fatty Iiver disease显示文摘 | Merat S Khadem SF Nouraie M | 2010 | Arch lran Med2010，13，1： | 1 |
| 17 | Combination resonances in a rotating shaft显示文摘 | HOSSEINI S A A KHADEM S E | 2009 | Mechanism and Machine Theory2009，44，8： | 1 |
| 18 | Is there a role for statins in atrial fibrillation 显示文摘 | Ariyarajah V Dawe DE Khadem A | 2009 | Pacing Clin Electrophysiol2009，32，8： | 1 |
| 19 | Decreased blood pressure with corresponding decrease inadhesive molecules in diabetic rats caused by vitamin Eadministxation显示文摘 | Shirpoor A Khadem Ansari MH Heshmatian B | 2012 | J Diabetes2012，4，4： | 1 |
| 20 | Introduction of modified comparison functions for vibration analysis of a rectangular cracked plate显示文摘 | Khadem S E Rezaee M | 2000 | $tnn''anl of Sound and Vibralion2000，236，2： | 1 |
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