| 1 | 皮肤纤维瘤、细胞性纤维组织细胞瘤和隆凸性皮肤纤维肉瘤中CD163的表达与CD68、CD34及XⅢa因子表达的比较显示文摘Background: Distinction between cellular fibrous histiocytomas (FHs) with a deep component and dermatofibrosarcoma protuberans (DFSPs) can pose diagnostic problems. While cases of DFSPs. CD68, CD34, and Factor XIIIa are helpful in distinguishing between these entities, none are diagnostically absolute. Recent work with CD163, a hemoglobin scavenger receptor, has demonstrated that this marker has high specificity for monocytes, macrophages, and histiocytes. Our goal is to evaluate the utility of CD163 in the diagnosis of dermatofibromas (DFs), cellular FHs, and DFSPs. Methods: Sixty cases including 19 DFs, 23 cellular FHs with a deep component, and 18 DFSPs were tested with antibodies against CD163, CD68, CD34, and Factor XIIIa. Results: CD163 was expressed in 17/19 (89% )- DFs, 23/23 (100% ) cellular FHs, and 3/18 (17% )DFSPs. CD68 was positive in 8/19 (42% ) DFs, 19/23 (83% ) cellular FHs, and 1/16 (6% ) DFSPs. CD34 was expressed in 1/19 (5% ) DFs, 5/23 (22% ) cellular FHs, and 100% of DFSPs. Factor XIIIa labeled 4/19 (21% ) DFs, 11/23 (48% ) cellular FHs, and 0/17 cases of DFSPs. Conclusions: CD163 expression is helpful in distinguishing between cellular FHs and DFSPs and will be useful in a panel of antibodies when these entities are in the differential diagnosis. | Sachdev R. Sundram U. 吴佳纹 | 2006 | 世界核心医学期刊文摘(皮肤病学分册)2006，2，8： | 2 |
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