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| 1 | 苹果轮纹病菌侵染机制的研究(英文)显示文摘苹果轮纹病菌(Botryosphaeriaberengrianaf.sppiricola)能在培养基及活体内产生一系列果胶酶:多聚半乳糖醛酸酶(PG)、聚甲基半乳糖醛酸酶(PMG)、多聚半乳糖醛酸反式消除酶(PGTE)和果胶甲基反式消除酶(PMTE)。其中PG和PMG是降解果实胞壁的主要酶类,在整个致病过程中起重要作用。从结果可看出PG活性随着侵染的进展而升高,PMG的作用在侵染前期更大一些,2种果胶酶可能是引起被接种苹果果皮上还原糖变化的重要因素。接种与未接种果实果皮的pH值差异随侵染进程而降低,接种40d后,接种处pH值开始低于健康组织的pH值,这一变化可能造成细胞壁软化而有利于PG和PMG活动。接种后10~20d,PG活性及组织中还原糖的增长速度比其他阶段要快。对侵染点的病原组织学研究进一步表明,病菌产生的各种果胶酶不论是在侵染初期还是后期都是重要的致病物质。 | 李广旭 沈永波 高艳敏 陈杰 Jie Youl Uhm | 2007 | 果树学报2007，24，1： | 33 |
| 2 | Amygdalin inhibits genes related to cell cycle in SNU-C4 human colon cancer cells显示文摘AIM: The genes were divided into seven categories according to biological function; apoptosis-reiated, immune response-related, signal transduction-related, cell cyclerelated, cell growth-related, stress response-related and transcription-related genes.METHODS: We compared the gene expression profiles of SNU-C4 cells between amygdalin-treated (5 mg/mL,24 h) and non-treated groups using cDNA microarray analysis. We selected genes downregulated in cDNA microarray and investigated mRNA levels of the genes by RT-PCR. RESULTS: Microarray showed that amygdalin downregulated especially genes belonging to cell cycle category: exonuclease 1 (EXO1), ATP-binding cassette, sub-family F, member 2 (ABCF2), MRE11 meiotic recombination 11 homolog A (MRE114), topoisomerase (DNA) I (TOP1), and FK506 binding protein 12-rapamycin-associated protein 1 (FRAP1). RT-PCR analysis revealed that mRNA levels of these genes were also decreased by amygdalin treatment in SNU-C4 human colon cancer cells.CONCLUSION: These results suggest that amygdalin have an anticancer effect via downregulation of cell cycle-related genes in SNU-C4 human colon cancer cells,and might be used for therapeutic anticancer drug. | Hae-Jeong Park Seo-Hyun Yoon Long-Shan Han Long-Tai Zheng Kyung-Hee Jung Yoon-Kyung Uhm Je-Hyun Lee Ji-Seon Jeong Woo-Sang Joo Sung-Vin Yim Joo-Ho Chung Seon-Pyo Hong | 2005 | World Journal of Gastroenterology2005，11，33： | 23 |
| 3 | Flow Field Around Rushton Turbine in Stirred Tank by Particle Image Velocimetry Measurement显示文摘In this paper, particle image velocimetry (PIV) was used to measure the mean and root meansquare(RMS) velocity in the stirred tank with six-flat blade Rushton turbine and with no baffles. Two typesof motion patterns were studied. One was that the impeller runs at constant speed, the other was that the impellerruns at time-dependent speed and in a periodic way. The emphasis of the paper was on the comparison of meanand RMS velocity vector maps and profiles between these two types of motion patterns, and especial attention waspaid to the comparison of the mean velocity, time-averaged RMS velocity, phase averaged RMS velocity betweenthe constant 3 RPS (revolution per second) and time-dependent operation. The Reynolds number was between 763and 1527. The study explained the mechanism that time-dependent RPS is more efficient for mixing than that ofconstant RPS. | 高殿荣 ACHARYA Sumanta 王益群 UHM Jongho | 2004 | Chinese Journal of Chemical Engineering2004，12，6： | 7 |
| 4 | 一般人群中腹型肥胖和新发心房颤动的关系显示文摘已知身高越高,体质量越大,心房颤动发生风险越高。然而,心房颤动的风险是否与腹型肥胖有关尚不清楚。Baek等纳入韩国国民健康保险计划全国样本队列中基线无心房颤动的成人501 690人,年龄(47.6±14.3)岁,女性250 664人,占50%。测定其体质量指数(body mass index,BMI)和腰围,将BMI〈18.5kg/m2定义为低体质量,18.5~〈25.0kg/m2定义为正常体质量;25.0~〈30.0kg/m2定义为超重;≥30.0kg/m2定义为肥胖;将腰围≥90(男性)和≥80cm(女性)定义为腹型肥胖。 | 刘莉 叶鹏 Baek YS Yang PS Kim TH Uhm JS Park J Pak HN Lee MH Joung B | 2017 | 中华高血压杂志2017，25，9： | 4 |
| 5 | Presentation,management,and outcome of newly diagnosed glioblastoma in elderly patients显示文摘OBJECT: Optimum management for elderly patients with newly diagnosed glioblastoma(GBM) in the temozolomide(TMZ) era is not well defined.The object of this study was to clarify outcomes in this population.METHODS: The authors retrospectively reviewed 105 consecutive cases involving elderly patients(age ≥ 65 years) with newly diagnosed GBM who were treated at the Mayo Clinic between 2003 and 2008.RESULTS: The patients' median age was 74 years(range 66-87 years),and the median Karnofsky Performance Status(KPS) score was 80(range 40-90).Half of the patients underwent biopsy and half underwent resection.Patients with deep-seated lesions(19 patients [18%]) or multifocal lesions(34 patients [32%]) were more likely to have biopsy than resection(p = 0.0001 and 0.0009,respectively).New persistent neurological deficits developed in 7 patients(6.7%).Postoperative hemorrhage occurred in 6 patients(5.7%),all of whom underwent biopsy.Complete follow-up data regarding adjuvant treatment was available in 84 patients.Forty-one(49%) were treated with chemotherapy(mostly TMZ) and radiation therapy(RT),and 23(27%) with RT alone.Nineteen(23%) received only palliative care after surgery(more common with biopsy,p = 0.03).Chemotherapy complications occurred in 28.6%(Grade 3 or 4 hematological complications in 11.9%).The median values for progression-free survival(PFS) and overall survival(OS) were 3.5 and 5.5 months.In a multivariate analysis,younger age(p = 0.03,risk ratio [RR] 0.34,95% CI 0.13-0.89),single lesion(p = 0.02,RR 0.51,95% CI 0.30-0.89),resection(p = 0.04,RR 0.54,95% CI 0.31-0.94),and adjuvant treatment(p = 0.0001,RR 0.24,95% CI 0.11-0.49) were associated with better OS.Only adjuvant treatment was significantly associated with prolonged PFS(p = 0.0007,RR 0.27,95% CI 0.13-0.57).With combined therapy with resection,RT,and chemotherapy,the median PFS and OS were 8 and 12.5 months,respectively.CONCLUSIONS: The prognosis for GBM worsens with increasing age in elderly patients.With important risks,resection and adjuvant treatment are associated with prolonged survival.Although selection bias cannot be excluded in this retrospective study,advanced age alone should not necessarily preclude optimal resection followed by adjuvant radiochemotherapy. | Tanaka S Meyer FB Buckner JC Uhm JH Yan ES Parney IF | 2013 | 中国神经肿瘤杂志2013，11，1： | 4 |
| 6 | The Correlation of Endoscopic and Histological Diagnosis of Gastric Atrophy显示文摘 | Alisher Eshmuratov Jong Chun Nah Nayoung Kim Hye Seung Lee Hee Eun Lee Byoung Hwan Lee Min Sik Uhm Young Soo Park Dong Ho Lee Hyun Chae Jung In Sung Song | 2010 | Digestive Diseases and Sciences2010，，5： | 2 |
| 7 | Aberrant promoter CpG islands methylation of tumor sup-pressor genes in cholangiocarcinoma显示文摘 | Uhm KO Lee ES Lee YM | 2008 | Onco 1 Res2008，17，4： | 1 |
| 8 | Clinical outcomes of metastatic breast cancer patients with triple-negative phenotype who received platinumcontaining chemotherapy显示文摘 | Yi S Uhm J Cho E | 2008 | J Clin Oncol2008，26，15： | 1 |
| 9 | TeOz nanoparticles synthe sized by evaporation of tellurium in atmospheric microwaveplasma torchflame 显示文摘 | Cho S C Hong Y C Uhm H S | 2006 | Chem Phys Lett2006，429，： | 1 |
| 10 | Clinical outcomes of metastatic breast can-cer p8tients with triple-negative phenol type who received platinumcontaining chemotherapy显示文摘 | Yi S Uhm J Cho E | 2008 | J ClinOneol2008，26，： | 1 |
| 11 | Analytical investiga tion of electrical breakdown properties in a nitrogen-SF6 mix turegas显示文摘 | Uhm H S Byeon Y S Song K B | 2010 | Physics of Plasmas2010，17，11： | 1 |
| 12 | Intergranular Corrosion of Ti-Stabilized 11 wt% Cr Ferritic Stainless Steel for Automotive Exhaust Systems 显示文摘 | Kim J K Kim Y H Uhm S H | 2009 | Corrosion Science2009，51，11： | 1 |
| 13 | A phase Ⅱ study of oxaliplatin in combination with doxorubicin as first-line systemic chemotherapy in patients with inoperable hepatocellular carcinoma显示文摘 | Uhm JE Park JO Lee J | 2009 | Cancer Chemother Pharmacol2009，63，5： | 1 |
| 14 | Prognostic model to predict survival fol-lowing first-line chemotherapy in patients with metastatic gastric ade-nocarcinoma显示文摘 | Lee J Lim T Uhm JE | | 0，，05： | 1 |
| 15 | Randomized phase Ⅱ study of gefitinib versus erlotinib in patients with advanced non-small cell lung cancer who failed previous chemotherapy显示文摘 | Kim ST Uhm JE Lee J | | 0，，01： | 1 |
| 16 | Incidence,risk factors,and Long-Term outcomes of sclerotic Grafl-versus-Host disease after allogeneic hematopoietic cell transplantation显示文摘 | Uhm J Hamad N Shin EM | 2014 | Biol Blood Marrow Transplant2014，20，11： | 1 |
| 17 | Production of Nanocrystalline Y2Oa : Eu Powder by Microwave Plasma-Torch and Its Characterization 显示文摘 | Cho S C Uhm H S Bang C U | 2009 | Thin Solid Films2009，517，： | 1 |
| 18 | Production of highcontent inulo-oligosaccharides from inulin by a purified endoinulinase显示文摘 | Yun J W Kim D H Uhm T B | 1997 | Biotechnology Letters1997，19，9： | 1 |
| 19 | Breakdown temperature of electrons in SF6 gas显示文摘 | Uhm H S Choi E H Cho G etal | 2010 | Applied Physics Letters2010，97，16： | 1 |
| 20 | Beta-amyloid increases the expression level of ATBF1 re sponsible for death in cultured cortical neurons显示文摘 | JUNG C G UHM K O MIURA Y | 2011 | Mol Neurodegener2011，27，6： | 1 |
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