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| 1 | Proton pump inhibitors increase the severity of hepatic encephalopathy in cirrhotic patients显示文摘BACKGROUND Liver cirrhosis is the late stage of hepatic fibrosis and is characterized by portal hypertension that can clinically lead to decompensation in the form of ascites,esophageal/gastric varices or encephalopathy.The most common sequelae associated with liver cirrhosis are neurologic and neuropsychiatric impairments labeled as hepatic encephalopathy(HE).Well established triggers for HE include infection,gastrointestinal bleeding,constipation,and medications.Alterations to the gut microbiome is one of the leading ammonia producers in the body,and therefore may make patients more susceptible to HE.AIM To investigate the relationship between the use of proton pump inhibitors(PPIs)and HE in patients with cirrhosis.METHODS This is a single center,retrospective analysis.Patients were included in the study with an admitting diagnosis of HE.The degree of HE was determined from subjective and objective portions of hospital admission notes using the West Haven Criteria.The primary outcome of the study was to evaluate the grade of HE in PPI users versus non-users at admission to the hospital and throughout their hospital course.Secondary outcomes included rate of infection,gastrointestinal bleeding within the last 12 mo,mean ammonia level,and model for end-stage liver disease scores at admission.RESULTS The HE grade at admission using the West Haven Criteria was 2.3 in the PPI group compared to 1.7 in the PPI nonuser group(P=0.001).The average length of hospital stay in PPI group was 8.3 d compared to 6.5 d in PPI nonusers(P=0.046).Twenty-seven(31.8%)patients in the PPI user group required an Intensive Care Unit admission during their hospital course compared to 6 in the PPI nonuser group(16.7%)(P=0.138).Finally,10(11.8%)patients in the PPI group expired during their hospital stay compared to 1 in the PPI nonuser group(2.8%)(P=0.220).CONCLUSION Chronic PPI use in cirrhotic patients is associated with significantly higher average West Haven Criteria for HE compared to patients that do not use PPIs. | Matthew Fasullo Prashanth Rau Dong-Qi Liu Erik Holzwanger Jomol P Mathew Yurima Guilarte-Walker Gyongyi Szabo | 2019 | World Journal of Hepatology2019，11，6： | 4 |
| 2 | Kinetics of the thermal decomposition of cellulose under the experimental conditions of thermal analysis: Theoretical extrapolations to higher heating rates显示文摘 | SZABO P | 1994 | Biomass and Bioenergy1994，7，16： | 1 |
| 3 | 18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease显示文摘 | RELKIN NR SZABO P ADAMIAK B | 2009 | Neurobiol Aging2009，30，11： | 1 |
| 4 | Evolution of surface functional groups in a series of progressively oxidized gra phite oxides 显示文摘 | Szabo T Berkesi O Forgo P | 2006 | Chem Mater2006，18，11： | 1 |
| 5 | Effect of Deletion of Chitin Synthase Genes on Mycelial Morphology and Culture Viscosity in Aspergillus oryzae显示文摘 | M tiller C Hansen K Szabo P | 2003 | Biotechnology and Bioengineering2003，81，5： | 1 |
| 6 | The Unfolding Web of Innate Immune Dysregulation in Alcoholic Liver Injury显示文摘 | Szabo G Mandrekar P Petrasek J | | 0，，： | 1 |
| 7 | Role of the peroxynitrite-poly (ADP- ribose) polymerase pathway in human disease显示文摘 | Pacher P Szabo C | 2008 | The American Journal of Pathology2008，173，： | 1 |
| 8 | The proximal biceps as a pain gene- rator and results of tenotomy 显示文摘 | Szabo 1 Boileau P Waleh G | 2008 | Sports Med Arthrosc2008，16，3： | 1 |
| 9 | Aged-associated defects in B lymphocyte development显示文摘 | Szabo P Shen S Weksler ME | 1999 | Exp Gerontol1999，，34： | 1 |
| 10 | Evolution of sur- face functional groups in a series of progressively oxi- dized graphite oxides 显示文摘 | Szabo T Berkesi O Forgo P | 2006 | Chemistry of Materials2006，18，11： | 1 |
| 11 | Invasive breast cancer:carrelation of dynamic MR features with prognostic factors显示文摘 | Szabo BK Aspelin P Kristoffersen WM | 2003 | Eur Radiol2003，13，11： | 1 |
| 12 | Stochastic maintenance of overlays in structured P2P systems 显示文摘 | Kersch P Szabo R Cheng L Jean K and Galis A | 2008 | Computer Communications2008，31，3： | 1 |
| 13 | Maturation of B cell precursors is impaired in thymic-deprived nude and old mice显示文摘 | Szabo P Zhao K Kinnan I | 1998 | J Immunol1998，，161： | 1 |
| 14 | Glucose-induced inhibition of in vitro bone mineralization显示文摘 | Balint E Szabo P Marshall CF | 2001 | Bone2001，28，1： | 1 |
| 15 | Therapeutic effects of xanthine oxidase inhibitors:renaissance half a century after the discovery of allopurinol显示文摘 | Pacher P Nivorozhkin A Szabo C | 2006 | Pharmacol Rev2006，58，1： | 1 |
| 16 | The two-component ad- juvant IC31 boosts type I interferon production of human mono- cyte-derived dendritic ceils via ligation of endosomal TLRs 显示文摘 | Szabo A Gogolak P Pazmandi K | 2013 | PLoS One2013，8，55： | 1 |
| 17 | Comparison of CT-and MRI- based clinical target volumes for 3-dimensional conformal external- beam radiotherapy of prostate cancer 显示文摘 | Szabo Z Agoston P Major T | 2012 | Magy Onkol2012，56，： | 1 |
| 18 | Signaling pathways in alco- hol-induced liver inflammation 显示文摘 | Mandrekar P Szabo G | 2009 | J Hepatol2009，50，6： | 1 |
| 19 | Glucose-induced inhibition of in vitro bone mineralization显示文摘 | Balint E Szabo P Marshall CF | | 0，，01： | 1 |
| 20 | Signalling pathways in alcohol-induced liver inflammation显示文摘 | Mandrekar P Szabo G | 2009 | J Hepato12009，50，： | 1 |
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