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| 1 | Preoperative immunonutrition in patients undergoing liver resection:A prospective randomized trial显示文摘BACKGROUND Preoperative supplementation with immunonutrients, including arginine and n-3 fatty acids, has been shown in a number of systematic reviews to reduce infectious complications in patients who have undergone gastrointestinal surgery. Limited information, however, is available on the benefits of nutritional supplementation enriched with arginine and n-3 fatty acids in patients undergoing liver resection.AIM To evaluate the effects of preoperative nutritional supplementation enriched with arginine and n-3 fatty acids on inflammatory and immunologic markers and clinical outcome in patients undergoing liver resection.METHODS Thirty-four patients undergoing liver resection were randomized to either five days of preoperative Impact? [1020 kcal/d, immunonutrition(IMN) group], or standard care [no supplementation, standard care(STD) group]. Nutritional status was measured at study entry by subjective global assessment(SGA).Functional assessments(grip strength, fatigue and performance status) were carried out at study entry, on the day prior to surgery, and on postoperative day(POD) 7 and 30. Inflammatory and immune markers were measured at study entry, on the day prior to surgery, and POD 1, 3, 5, 7, 10 and 30. Postoperative complications were recorded prospectively until POD30.RESULTS A total of 32 patients(17 IMN and 15 STD) were analysed. All except four patients were SGA class A. The plasma ratio of(eicosapentaenoic acid plus docosahexaenoic acid) to arachidonic acid was higher in IMN patients on the day prior to surgery and POD 1, 3, 5 and 7(P < 0.05). Plasma interleukin(IL)-6 concentrations were elevated in the IMN group(P = 0.017 for POD7). No treatment effect was detected for functional measures, immune response(white cell count and total lymphocytes) or markers of inflammation(C-reactive protein,tumour necrosis factor-α, IL-8, IL-10). There were 10 patients with infectious complications in the IMN group and 4 in the STD group(P = 0.087). Median hospital stay was 9(range 4–49) d in the IMN group and 8(3-34) d in the STD group(P = 0.476).CONCLUSION In well-nourished patients undergoing elective liver resection, this study failed to show any benefit of preoperative immunonutrition. | Kylie Russell Han-Guang Zhang Lyn K GillANDers Adam SJR Bartlett Helena L Fisk Philip C Calder Peter J Swan Lindsay D Plank | 2019 | World Journal of Hepatology2019，11，3： | 3 |
| 2 | The effect of apoliporotein Ee4 in the relationships of smoking and drinking to cognitive function显示文摘 | Carmelli D Swan GE Reed T | 1999 | Neuroepidemiology1999，18，： | 1 |
| 3 | What are natural antisense transcripts good for? 显示文摘 | WERNER A SWAN D | 2010 | Biochem Soc Trans2010，38，4： | 1 |
| 4 | Methods for Measuring Temporary Health States for Cost-Utility Analyses显示文摘 | Wright D R Wittenberg E Swan J S Miksad RA Prosser LA | 2009 | Pharmacoeconomics2009，27，9： | 1 |
| 5 | Reconstructing forest history from live and dead plant material:an approach to the study of forest succession in southwest New Hampshire 显示文摘 | Henry J D Swan J M A | 1974 | Ecology1974，55，： | 1 |
| 6 | High-throughput gene mapping in Caenorhabditis elegans 显示文摘 | Swan K A Curtis D E McKusick K B | 2002 | Genome Res2002，7，： | 1 |
| 7 | Product life cycle research:a literature review显示文摘 | RINK D R SWAN J E | | 0，，03： | 1 |
| 8 | Extreme ocean waves--part I: the practical application of fully nonlinear wave modeling显示文摘 | Bateman W J D Katsardi V Swan C | 2012 | Applied Ocean Research2012，34，： | 1 |
| 9 | Garenoxacin phar- maeokinetics in subjects with renal impairment显示文摘 | KRISHNA G GAJJAR D SWAN S | 2007 | Curr Med Res Opin2007，23，3： | 1 |
| 10 | Human papillomavirus(HPV) DNA copy number is dependent on grade of cervical disease and HPV type显示文摘 | Swan D C Tucker R A Tortolero-Luna G | 1999 | J Clin Microbiol1999，37，： | 1 |
| 11 | Surface soil moisture and stubble management practice effects on the progress of infection of wheat by Fusarium pseudograminearum 显示文摘 | Swan L J Backhouse D Burgess L W | 2000 | Australian Journal of Experimental Agriculture2000，40，： | 1 |
| 12 | Social physique anxiety in postmenopausal women显示文摘 | Ransdell L B Wells C L Manore M M Swan P D & Corbin C | 1998 | Journal of Women & Aging1998，10，： | 1 |
| 13 | Outcome of necrosectomy in acute pancreatitis: the case for continued vigilance显示文摘 | Beattie GC Mason J Swan D | 2002 | Scand J Gastroenterol2002，37，： | 1 |
| 14 | Quantitative thickness estimates from the spectral response of AVO measurements 显示文摘 | Nowak E J Swan H W Lane D | | Geophys ies0，73，1： | 1 |
| 15 | Phthalates and other additives in plastics: Human exposure and associated health out- comes显示文摘 | Meeker J D Sathyanarayana S Swan S H | 2009 | Philosophical Transactions of the Royal Society of Lor- don B2009，364，1526： | 1 |
| 16 | What do natural antisense transcripts regulate? 显示文摘 | Werner A C arlile M Swan D | 2009 | RNA Biol2009，6，1： | 1 |
| 17 | A10-year review of benign and malignant peripheral nerve sheath tumors in a single center:clinical and radiographic features can help to differentiate benign from malignant lesions显示文摘 | FURNISS D SWAN M C MORRITT D G | 2008 | Plast Reconstr Surg2008，121，： | 1 |
| 18 | Open Software for biologists:from famine to feast显示文摘 | Field D Tiwari B Booth T Houten S. Swan D. Bertrand N.Thurston M | | 0，，： | 1 |
| 19 | A knowledge-focused perspective on the diffusion and adoption of complex in- formation technologies : The BRP example 显示文摘 | Newell S Swan J Galliers R D | 2000 | Information Systems Journal2000，10，3： | 1 |
| 20 | Directing differentiation in Theileria annulata:old methods and new possibilities for control of apicomplexan parasites显示文摘 | Shiels B Swan D McKellar S | 1998 | Int J Parasitol1998，28，11： | 1 |
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